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Chemical Structure| 139354-85-1 Chemical Structure| 139354-85-1

Structure of 139354-85-1

Chemical Structure| 139354-85-1

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Product Details of [ 139354-85-1 ]

CAS No. :139354-85-1
Formula : C14H20N2O5S
M.W : 328.38
SMILES Code : O=C(OCC)C(C1=CSC(NC(OC(C)(C)C)=O)=N1)CC=O
MDL No. :MFCD18452058

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Application In Synthesis of [ 139354-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 139354-85-1 ]

[ 139354-85-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 139354-85-1 ]
  • [ 10272-49-8 ]
  • [ 691876-43-4 ]
YieldReaction ConditionsOperation in experiment
96% With sodium triacetoxyborohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 0.5h; A mixture of 3.42 g (10 mmol) of ethyl 2- (2-TERT- BUTOXYCARBONYLAMINOTHIAZOL-4-YL)-3-FORMYLPROPANOATE (Intermediate 36), 1.61 g (10 mmol) of phenylpiperidine hydrochloride, 2.6 g (20 mmol) of DIEA and 4.22 g (20 mmol) of sodium triacetoxyborohydride in 20 ML of CH2C12 at RT was stirred for 0.5 h. The reaction mixture was diluted with 50 ML of CH2C12 and washed with water (3x 100 ML). The organic phase was dried over NA2SO4 and concentrated in vacuo. 4.55 g (96%) of the title compound was obtained as a gummy material. 1H NMR (300 MHz, CDC13) : 8 1. 21 (t, 3H), 1.53 (s, 9H), 1.70-1. 90 (m, 4H), 1.95-2. 15 (m, 3H), 2.20-2. 55 (m, 4H), 3.00-3. 10 (m, 2H), 3.77 (t, 1H), 4.10-4. 20 (m, 2H), 6.69 (s, 1H), 7.18-7. 35 (m, 5H). Mass Spectrum (NH3-CI) : m/z 474 (M+1).
 

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