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Chemical Structure| 1399119-66-4 Chemical Structure| 1399119-66-4

Structure of 1399119-66-4

Chemical Structure| 1399119-66-4

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Product Details of [ 1399119-66-4 ]

CAS No. :1399119-66-4
Formula : C16H11FN2O4
M.W : 314.27
SMILES Code : O=C(O)C1=CC(CN2C(NC(C3=C2C=CC=C3)=O)=O)=CC=C1F

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Application In Synthesis of [ 1399119-66-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1399119-66-4 ]

[ 1399119-66-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1399119-66-4 ]
  • [ 59702-07-7 ]
  • C21H19FN4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
A solution of 5 - ((2,4-dioxo-3,4-dihydroquinazolin-1 (211) -yl) methyl) -2-fluorobenzoic acid, EDC (123 mg, 0.64 mmol ), H0Bt (86 mg, 0.64 mmol) and DIEA (125 mg, 0.96 mmol)In a flask, about 3 mL of anhydrous DMF was added, stirred at room temperature for 15 min, followed by the dropwise addition of 1-methyl-niazin-2-one (225 mg,1.97 mmol) in DMF was added to the reaction solution, stirred overnight at r.t. The reaction was poured into 100 mL of water and treated with 100 mL of DCMThe organic layer was washed successively with water (100 mL), saturated NaCl (100 mL) and water (100 mL), concentrated under reduced pressure and subjected to column chromatography to give the title compound.
 

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