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CAS No. : | 140-38-5 | MDL No. : | MFCD00014788 |
Formula : | C7H7ClN2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | RECCURWJDVZHIH-UHFFFAOYSA-N |
M.W : | 170.60 | Pubchem ID : | 8796 |
Synonyms : |
|
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 44.05 |
TPSA : | 55.12 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.06 cm/s |
Log Po/w (iLOGP) : | 1.2 |
Log Po/w (XLOGP3) : | 1.8 |
Log Po/w (WLOGP) : | 1.64 |
Log Po/w (MLOGP) : | 1.73 |
Log Po/w (SILICOS-IT) : | 0.84 |
Consensus Log Po/w : | 1.44 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.3 |
Solubility : | 0.848 mg/ml ; 0.00497 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.58 |
Solubility : | 0.452 mg/ml ; 0.00265 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.65 |
Solubility : | 0.383 mg/ml ; 0.00224 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.27 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P280-P301+P310+P330-P302+P352-P305+P351+P338 | UN#: | 2811 |
Hazard Statements: | H301-H315-H317-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28%; 55% | With trichloroisocyanuric acid; In acetonitrile; at 25℃; | General procedure: TCCA (0.083 mmol) was added to a stirred solution of the substituted N-phenylurea (0.25 mmol) in MeCN (5-10 mL) at r.t. (25 C) and the mixture was stirred until completion of the reaction (TLC). The reac- tion was quenched with 15 % NaHSO3(10 mL). The final mixture was extracted with EtOAc and washed with brine and water. The organic layer was separated, dried over anhydrous sodium sulfate followed by removal of solvent under reduced pressure. The crude products were separated on silica gel thin-layer chromatography plates using EtO- Ac/hexanes as eluent. For the bromination and iodination reactions, the above procedure was performed using 0.125 mmol of TBCA or TICA. After quenching the reaction with NaHSO3 solution, the crude products precipitated and were filtered off. They did not require further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrazine hydrate; In ethanol; for 0.5h;Reflux; | General procedure: To an aqueous solution of 4-(substituted)phenyl urea (5) (0.1mol), an equimolar quantity of hydrazine hydrate and ethanol(2 mL) was added. The reaction mixture was refluxed for 30 minand cooled in ice. Sodium hydroxide (4 g) was added to makethe reaction mixture alkaline, before refluxing. The productwas filtered under suction and recrystallized from ethanol [6]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84.8% | With acetic acid; In water; at 50℃; for 2h; | General procedure: To a solution of substituted aniline (0.1 mol) dissolved in 48 mL glacial acetic acid and 96 mL H2O, sodium cyanate (13 g, 0.2 mol) in warm water (90 mL) was added with continuous stirring. The mixture was warmed to 50 C for 2 h and then cooled in ice, The crude solid, thus obtained was filtered, dried, and recrystallized with boiling water. |
With acetic acid; In water; for 0.5h; | General procedure: Aniline and/or p-substituted aniline (4) (0.1 mol) was dissolved in glacial acetic acid (10 mL) and diluted with water (up to 100 mL). To this solution an equimolar (0.1 mol) quantity of sodium cyanatein warm water (50 mL) was added with stirring. The reaction mixture was allowed to stand for 30 min, and then compounds were filtered, washed with water and dried after recrystallization from boiling water [6]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With silver; water; for 1h;Reflux; | General procedure: A mixture of the appropriate cyanamide (1.0 mmol), water(10 mL) and Ag NPs (5.0 mg) was stirred under reflux conditionsfor 1 h. After completion of reaction (as monitored by TLC), Ag NPs were separated from the reaction mixture by centrifugation. The desired pure products were characterized by 1H NMR, 13CNMR, FT-IR, elemental analysis (CHN), and melting points. The physical data (mp, IR, NMR) of known compounds were found to be identical with those reported in the literature [15,17]. |
93% | With formic acid; water; at 20℃; for 0.333333h;Green chemistry; | General procedure: Also, to see the effect of HCOOH, the hydration reaction of arylcyanamidewas carried out in the presence of HCOOH. So, arylcyanamide(1.0 mmol), palladium nano-particle catalyst (30 mg),water (5.0 ml) and 98% formic acid (2.0 mmol) were added to around-bottomed flask, and the reaction mixture was stirred atroom temperature for the appropriate time (Table 2). After completionof the reaction as monitored by TLC, the catalyst was separatedby the strong magnet, the aqueous layer extracted withethyl acetate, washed with water, dried over MgSO4, filtered andevaporated under reduced pressure, and a crystallization stepwas performed using acetone/n-hexane to afford the pure product. |
87% | With Acetaldehyde oxime; cerium(IV) oxide; In ethanol; for 2h;Reflux; Inert atmosphere; | General procedure: Cyanamide (1.0 mmol), acetaldoxime (2.0 mmol), nano cerium oxide (5.0 mol%) and EtOH (5 mL) were added to a 25 mL roundbottom flask equipped with magnetic stirrer. The mixture was heated to reflux under a nitrogen atmosphere for 2 h. After cooling to room temperature, the solid was filtered, washed with EtOH and the filtrate evaporated. The filtered catalyst can be recycled after washing with CH2Cl2and drying for 2 h. The crude product was purified by column chromatography. All the isolated compounds were characterised by m.p., IR, 1H NMR, 13C NMR and elemental analysis. The physical data (m.p., IR, NMR) of known compounds were found to be identical with those reported in the literature. |
0.1292 g | With hydrogenchloride; In ethanol; water; for 3h;Reflux; Inert atmosphere; | General procedure: To the solution of nitrile (1) in EtOH (0.1 M) was added 50wt% aqueous hydroxylaminesolution (1.2 equiv). The mixture was stirred at reflux temperature for 1.5 h under nitrogen. After cooling to room temperature, the reaction mixture was concentratedunder reduced pressure. The crude amidoxime (2) product was dissolved in CH2Cl2(0.1 M), and then ArSO2Cl (TsCl or o-NsCl, 1.05 equiv) and DIPEA (1.05 equiv)were added at 0 oC. The mixture was stirred under nitrogen atmosphere at room temperature for 3 h or at reflux temperature for 1 h (see reference 3 for details).3 Themixture was concentrated under reduced pressure. The crude cyanamide (3) productwas dissolved in the mixture of 1 N aqueous HCl solution and EtOH (1 N HCl / EtOH= 1 : 4, v/v, reaction concentration = 0.1 M). The mixture was stirred at reflux temperaturefor 3 h under nitrogen atmosphere. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was purified by flash column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonia; water; In acetone; at 0 - 20℃; | General procedure: Substituted aniline (54 mmol) wasadded dropwise to a solution of bis(trichloromethyl) carbonate (8.0 g, 27 mmol) in dry ethylacetate (30 mL) at 0-5 oC, the mixture was stirred for 1 h at room temperature and heated underreflux for 5 h, cooled on standing, then solvent was evaporated under reduced pressure to getsubstituted isocyanate. A solution of substituted isocyanate and acetone (20 mL) was addeddropwise to a mixture of ammonia (11 mL, 163 mmol) and acetone (10 mL) at 0-5 oC, themixture was stirred for 10 h at room temperature and evaporated under reduced pressure. Theresidue was washed with water and recrystallized from ethanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | EXAMPLE 11 As described in Example 6, but using 9.4 g of 4-chloroaniline (0.0735 mol) and dimethoxyethane as the solvent, 4-chlorophenylurea was obtained in a yield of 50% of theory. 1 H-NMR: 6.8-7.0 (s, broad, --NH2); 7.36 (d, aromat. --CH--); 7.51 (d, aromat. --CH--); 9.0 (s, --NH--). | |
50% | Example 11 As described in Example 6, but using 9.4 g of 4-chloroaniline (0.0735 mol) and dimethoxyethane as the solvent, 4-chlorophenylurea was obtained in a yield of 50% of theory. 1 H-NMR: 6.8-7.0 (s, broad, --NH2); 7.36 (d, aromat. --CH--); 7.51 (d, aromat. --CH--); 9.0 (s, --NH--). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In benzene; | EXAMPLE 11 Diphenyl alpha-[3-(4-chlorophenyl)ureido]-4-hydroxy-3-methoxybenzyl phosphonate. SPC1 A mixture of 34.1g (0.2 mole) of <strong>[140-38-5]4-chlorophenylurea</strong>, 62.1g (0.2 mole) of triphenyl phosphite, and 30.4g (0.2 mole) of vanillin in 150 ml of benzene is warmed at reflux for 2.5 hr. The reaction mixture is cooled and filtered to give a light yellow solid which is twice recrystallized from acetonitrileethylene dichloride: mp 190-194 dec; 31 P nmr -15.8 ppm (d, J = 22Hz); 1 H nmr delta9.1 (s, 1, NHC6 H4 C1), 8.7 (s, 1, OH), 6.7 -7.8 (m, 18, aryl and CHNH), 5.7 (d of d, 1, J = 22 and 10 Hz, PCHNH), 3.8 (s, 3, CH3). Anal. Calcd for C27 H24 ClN2 O6 P: C, 60.17; H, 4.48; Cl, 6.58; N, 5.19; P, 5.75. Found: C, 59.62; H, 4.36; Cl, 6.50; N, 5.13; P, 5.65. | |
In benzene; | EXAMPLE 11 Diphenyl alpha-[3-(4-chlorophenyl)ureido]-4-hydroxy-3-methoxybenzyl phosphonate STR19 A mixture of 34.1g (0.2 mole) of <strong>[140-38-5]4-chlorophenylurea</strong>, 62.1g (0.2 mole) of triphenyl phosphite, and 30.4g (0.2 mole) of vanillin in 150 ml of benzene is warmed at reflux for 2.5 hr. The reaction mixture is cooled and filtered to give a light yellow solid which is twice recrystallized from acetonitrile-ethylene dichloride: mp 190-194 dec; 31 P nmr - 15.8 ppm (d, J = 22Hz); 1 H nmr delta9.1 (s, 1, NHC6 H4 Cl), 8.7 (s, 1, OH), 6.7-7.8 (m, 18, aryl and CHNH), 5.7 (d of d, 1, J = 22 and 10 Hz, PCHNH), 3.8 (s, 3, CH3). Anal. Calcd for C27 H24 ClN2 O6 P: C, 60.17; H, 4.48; Cl, 6.58; N, 5.19; P, 5.75. Found: C, 59.62; H, 4.36; Cl, 6.50; N, 5.13; P, 5.65. | |
In benzene; | EXAMPLE 11 Diphenyl alpha-[3-(4-chlorophenyl)ureido]-4-hydroxy-3-methoxybenzyl phosphonate STR15 A mixture of 34.1g (0.2 mole) of <strong>[140-38-5]4-chlorophenylurea</strong>, 62.1g (0.2 mole) of triphenyl phosphite, and 30.4g (0.2 mole) of vanillin in 150 ml of benzene is warmed at reflux for 2.5 hr. The reaction mixture is cooled and filtered to give a light yellow solid which is twice recrystallized from acetonitrileethylene dichloride: mp 190-194 dec; 31 P nmr -15.8 ppm (d, J = 22Hz); 1 H nmr delta9.1 (s, 1, NHC6 H3 Cl), 8.7 (s, 1, OH), 6.7-7.8 (m, 18, aryl and CHNH), 5.7 (d of d, 1, J = 22 and 10 Hz, PCHNH), 3.8 (s, 3, CH3). Anal. Calcd for C27 H24 ClN 2 O6 P: C, 60.17; H, 4.48; Cl, 6.58; N, 5.19; P, 5.75. Found: C, 59.62; H, 4.36; Cl, 6.50; N, 5.13; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In 1,4-dioxane; N-methyl-acetamide; methanol; diethyl ether; acetone; | EXAMPLE 2 4-[N-(4-chlorophenyl)aminocarbonylamino]-2(5H)-furanone To a magnetically stirred suspension of <strong>[140-38-5]4-chlorophenylurea</strong> (2 g) in dioxane (4 ml), ethyl 4-chloroacetoacetate (1.63 ml) are added and the suspension is heated to reflux for two hours, then kept at toom temperature overnight. The yellowish gray precipitate is recovered by filtration and washed with the mother liquor, with methanol (2*1 ml) and finally with diethyl ether (2 ml). After drying under vacuum at 40 C. overnight, 1.34 g of crude product were obtained. The crude product is then suspended under reflux in 20 ml of dioxane for 45 minutes, then the suspension is allowed to return to room temperature and the solid is recovered by filtration and washed with dioxane (1 ml) and then with diethyl ether (2 ml). After drying overnight under vacuum at 40 C., 1.1 g of the product are obtained, which still contains some impurities. It is therefore dissolved in hot dimethylformamide (2.2 ml) and when a complete solution is obtained the heating bath is removed and the product reprecipitate in a short time. When the suspension reaches room temperature 11.2 ml of acetone are added and after stirring for 2 hours the solid is recovered by filtration and washed first with the mother liquor and then with acetone (2*3 ml). After drying under vacuum at 40 C. overnight, 0.73 g of off-white product are obtained, m.p.>254-256 C. TLC (silica gel, eluant methylene chloride/methanol 9:1; UV detection at 254 nm): single spot at Rf=0.39. Elem. Anal. (% calcd/found): C 52.29/52.05; H 3.59/3.60; N 11.09/10.99; Cl 14.03/14.05. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Reference Example 125: tert-butyl (2E)-2-([(4-chloroanilino)carbonyl]amino}carbonyl)-3-(5-chloro-2-methoxyphenyl)-2-propenylcarbamate (compound S125) To <strong>[140-38-5]N-<strong>[140-38-5](4-chlorophenyl)urea</strong></strong> (1.9 g) in N,N-dimethylformamide (35 ml) solution, sodium hydride (60% mineral oil dispersion) (460 mg) was added and the mixture was stirred at room temperature for 1 hour. Next, to the reaction mixture, a mixed solution obtained by adding 1,1'-carbonyldiimidazole (1.9 g) to the compound S23 (4 g) in tetrahydrofuran (35 ml) solution under ice cooling and stirring the mixture at room temperature for 45 minutes was added and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was diluted with ethyl acetate and saturated potassium hydrogensulfate aqueous solution, and the obtained solution was separated. The organic layer was washed with saturated saline, dried over with anhydrous sodium sulfate, then concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to obtain the title compound (2.6 g). NMR (CDCl3): delta10.79(1H, br), 9.46(1H, br), 7.7(1H, s), 7.5(2H, d, J=8.8Hz), 7.33(1H, dd, J=8.8, 2.5Hz), 7.30-7.20(3H, m), 6.87(1H d, J=8.8Hz), 4.92(1H br), 4.15(2H, d, J=6.4Hz), 3.84(3H, s), 1.46(9H, s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; water; potassium hydroxide; In acetonitrile; at 20℃; for 0.0333333h; | To a stirred solution of phenylthiourea 1 (1mmol) and 5% aq. KOH (5 mL) in acetonitrile (5 mL) was added DHPDMDO (0.332 g, 2mmol). The resulting mixture was allowed to stir at room temperature for an appropriate time (Table 2). After completion of the reaction as monitored by TLC, the reaction mixture was diluted with water (10mL) and the product was extracted in dichloromethan (3×5mL). The combined organic layer was washed with water (2×5mL) and dried over anhydrous Na2SO4. Evaporation of the solvent under reduced pressure gave almost pure products. Structures of the known products were established on the basis of their physical and spectroscopic (IR, 1H-NMR and 13C-NMR) data, which were consistent with those reported.[34,61] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
14% | With potassium fluoride; N,N'-Dibenzylethylenediamine;copper(l) iodide; In tetrahydrofuran; at 90℃; for 0.5h;Microwave irradiation; | A stirred suspension of (RS)-4-(4-iodo-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (1.60 g), <strong>[140-38-5]4-chlorophenylurea</strong> (0.81 g), potassium fluoride (2.88 g, 40 wt % on alumina), N,N'-dibenzylethylenediamine (0.14 ml) and copper(I) iodide (0.11 g) in THF (16 ml) in a sealed tube was heated at 90C. for 30 minutes under microwave irradiation. The mixture was then cooled to room temperature and filtered through celite. The filtrate was concentrated in vacuo and the residue was purified by column chromatography (SiO2; gradient: heptane/EtOAc) to give (RS)-4-{4-[3-(4-chloro-phenyl)-ureido]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.24 g, 14%) as a light yellow solid. MS (ISP): 392.1 ([{37Cl} M+H-C4H8]+), 390.1 ([{35Cl} M+H-C4H8]+). |
14% | With 40% potassium fluoride/alumina;copper(l) iodide; N,N'-Dibenzylethylenediamine; In tetrahydrofuran; at 90℃; for 0.5h;Sealed tube; Microwave irradiation; | f) (RS)-4- {4-[3-(4-Chloro-phenyl)-ureido]-phenyl} -2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl esterA stirred suspension of (RS)-4-(4-iodo-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert- butyl ester (1.60 g), <strong>[140-38-5]4-chlorophenylurea</strong> (0.81 g), potassium fluoride (2.88 g, 40 wt% on alumina), N,N'-dibenzylethylenediamine (0.14 ml) and copper(I) iodide (0.11 g) in THF (16 ml) in a sealed tube was heated at 90 C for 30 minutes under microwave irradiation. The mixture was then cooled to room temperature and filtered through celite. The filtrate was concentrated in vacuo and the residue was purified by column chromatography (Si02; gradient: heptane/EtOAc) to give (RS)-4- {4-[3-(4-chloro-phenyl)-ureido]-phenyl} -2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.24 g, 14%) as a light yellow solid. MS (ISP): 392.1 ([{37C1}M+H-C4H8]+), 390.1 ([{35C1}M+H-C4H8]+). |
Tags: 140-38-5 synthesis path| 140-38-5 SDS| 140-38-5 COA| 140-38-5 purity| 140-38-5 application| 140-38-5 NMR| 140-38-5 COA| 140-38-5 structure
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P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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