[ CAS No. 140-82-9 ] {[proInfo.proName]}

Name: 140-82-9|2-(2-(Diethylamino)ethoxy)ethanol|98%
Brand: Ambeed
SKU: A759646
Rating: 92 (30 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

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Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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Quality Control of [ 140-82-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 140-82-9 ]

Product Details of [ 140-82-9 ]

CAS No. :	140-82-9	MDL No. :	MFCD00020604
Formula :	C₈H₁₉NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VKBVRNHODPFVHK-UHFFFAOYSA-N
M.W :	161.24	Pubchem ID :	67327
Synonyms :

Calculated chemistry of [ 140-82-9 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	7
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	45.71
TPSA :	32.7 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.16 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.32
Log Po/w (XLOGP3) :	0.17
Log Po/w (WLOGP) :	0.34
Log Po/w (MLOGP) :	0.41
Log Po/w (SILICOS-IT) :	0.63
Consensus Log Po/w :	0.77

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.48
Solubility :	52.8 mg/ml ; 0.327 mol/l
Class :	Very soluble
Log S (Ali) :	-0.41
Solubility :	62.1 mg/ml ; 0.385 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.57
Solubility :	4.3 mg/ml ; 0.0267 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.0

Safety of [ 140-82-9 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	2735
Hazard Statements:	H312-H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 140-82-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 140-82-9 ]

[ 140-82-9 ] Synthesis Path-Downstream 1~58

1
[ 75-21-8 ]
[ 140-82-9 ]
[ 3603-40-5 ]

Reference： [1]Journal of the American Chemical Society,1932,vol. 54,p. 2928

2
[ 75-21-8 ]
[ 100-37-8 ]
[ 140-82-9 ]

Reference： [1]Journal of the American Chemical Society,1932,vol. 54,p. 2928
[2]Journal of the American Chemical Society,1933,vol. 55,p. 1066

3
[ 859780-32-8 ]
[ 140-82-9 ]
2-ethoxy-quinoline-4-carboxylic acid-[2-(2-diethylamino-ethoxy)-ethyl ester]; hydrochloride [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 495

4
[ 100119-45-7 ]
[ 140-82-9 ]
[ 13877-98-0 ]

Reference： [1]Patent: US2842585,1954,
[2]Journal of Pharmacy and Pharmacology,1958,vol. 10,p. 40,44

5
[ 10249-04-4 ]
[ 140-82-9 ]
2-butoxy-quinoline-4-carboxylic acid-[2-(2-diethylamino-ethoxy)-ethyl ester]; hydrochloride [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 495

6
[ 854863-91-5 ]
[ 140-82-9 ]
2-pentyloxy-quinoline-4-carboxylic acid-[2-(2-diethylamino-ethoxy)-ethyl ester]; hydrochloride [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 495

7
[ 628-89-7 ]
[ 109-89-7 ]
[ 140-82-9 ]

Reference： [1]Journal of the American Chemical Society,1940,vol. 62,p. 3316,3318

8
[ 1871-76-7 ]
[ 140-82-9 ]
[ 102700-71-0 ]

Reference： [1]Patent: US2842585,1954,

9
[ 2890-42-8 ]
[ 140-82-9 ]
[ 13877-96-8 ]

Reference： [1]Patent: US2842585,1954,
[2]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

10
[ 49802-71-3 ]
[ 140-82-9 ]
[ 102702-13-6 ]

Reference： [1]Patent: US2842585,1954,

11
[ 17380-62-0 ]
[ 140-82-9 ]
[ 77-23-6 ]

Reference： [1]Patent: US2842585,1954,

12
[ 140-82-9 ]
[ 292638-85-8 ]
[ 100050-23-5 ]

Reference： [1]Patent: US2824861,1955,

13
[ 140-82-9 ]
[ 80-62-6 ]
[ 87553-18-2 ]

Reference： [1]Patent: US2824861,1955,

14
[ 140-82-9 ]
[ 74-86-2 ]
[ 7307-78-0 ]

Reference： [1]Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya,1959,vol. 2,p. 769,773
Chem.Abstr.,1960,p. 8598,8599

15
[ 140-82-9 ]
[ 114456-81-4 ]

Reference： [1]Journal of the American Chemical Society,1954,vol. 76,p. 3163,3165
[2]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

16
[ 14258-40-3 ]
[ 109-89-7 ]
[ 140-82-9 ]

Reference： [1]Journal of the American Chemical Society,1954,vol. 76,p. 3163,3165

17
[ 114188-38-4 ]
[ 140-82-9 ]

Reference： [1]Journal of Pharmacy and Pharmacology,1960,vol. 12,p. 137T-152T

18
[ 94231-78-4 ]
[ 140-82-9 ]
benzo[<i>b</i>]pyrido[2,3-<i>e</i>][1,4]thiazine-10-carboxylic acid 2-(2-diethylamino-ethoxy)-ethyl ester [ No CAS ]

Reference： [1]Justus Liebigs Annalen der Chemie,1964,vol. 673,p. 102 - 112

19
[ 39889-69-5 ]
[ 140-82-9 ]
[ 95160-43-3 ]

Reference： [1]Farmaco, Edizione Scientifica,1963,vol. 18,p. 315 - 345

20
[ 75-04-7 ]
[ 140-82-9 ]
[ 116054-92-3 ]

Reference： [1]Journal of Pharmacy and Pharmacology,1960,vol. 12,p. 137T-152T

21
Propyl-propargylessigsaeurechlorid [ No CAS ]
[ 140-82-9 ]
[ 35812-12-5 ]

Reference： [1]Farmaco, Edizione Scientifica,1972,vol. 27,p. 217 - 234

22
[ 41641-76-3 ]
[ 140-82-9 ]
[ 96586-27-5 ]

Reference： [1]Farmaco, Edizione Scientifica,1963,vol. 18,p. 315 - 345

23
[ 2287-32-3 ]
[ 140-82-9 ]
[ 2293-39-2 ]

Reference： [1]Journal of Medicinal Chemistry,1965,vol. 8,p. 542 - 545

24
[ 2287-33-4 ]
[ 140-82-9 ]
[ 859-20-1 ]

Reference： [1]Journal of Medicinal Chemistry,1965,vol. 8,p. 542 - 545

25
[ 22004-65-5 ]
[ 140-82-9 ]
[ 2212-34-2 ]

Reference： [1]Arzneimittel-Forschung/Drug Research,1964,vol. 14,p. 1053 - 1055

26
[ 100-37-8 ]
[ 107-07-3 ]
[ 140-82-9 ]

Reference： [1]Arzneimittel-Forschung/Drug Research,1964,vol. 14,p. 1053 - 1055

27
[ 52835-16-2 ]
[ 140-82-9 ]
[ 99679-36-4 ]

Reference： [1]Journal of Fluorine Chemistry,1985,vol. 30,p. 37 - 58

28
[ 140-82-9 ]
[ 83935-62-0 ]
[ 83935-83-5 ]

Reference： [1]Acta Chimica Academiae Scientiarum Hungaricae,1982,vol. 110,p. 25 - 28
[2]Liebigs Annalen der Chemie,1988,p. 349 - 354

29
[ 140-82-9 ]
6-Chlorocarbonyl-3-methoxymethoxy-5-methyl-2'-nitro-biphenyl-2-carboxylic acid methyl ester [ No CAS ]
[ 127976-24-3 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 899 - 906

30
[ 140-82-9 ]
trans-2,3-dihydro-3-phenyl-1,4-benzodioxin-2-carboxylic acid [ No CAS ]
trans-2-<2-(diethylamino)ethoxy>ethyl-2,3-dihydro-3-phenyl-1,4-benzodioxin-2-carboxylate [ No CAS ]

Reference： [1]Farmaco, Edizione Scientifica,1981,vol. 36,p. 932 - 941

31
[ 140-82-9 ]
[ 136089-18-4 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

32
[ 63201-02-5 ]
[ 140-82-9 ]
2-<2-(diethylamino)ethoxy>ethyl 1-phenyl-1-cyclopropanecarboxylate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1994,vol. 37,p. 2285 - 2291

33
[ 71501-44-5 ]
[ 140-82-9 ]
2-<2-(diethylamino)ethoxy>ethyl 1-(4-chlorophenyl)-1-cyclopentanecarboxylate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1994,vol. 37,p. 2285 - 2291

34
[ 25145-43-1 ]
[ 140-82-9 ]
2-<2-(diethylamino)ethoxy>ethyl 2-phenylpropionate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1994,vol. 37,p. 2285 - 2291

35
[ 63200-97-5 ]
[ 140-82-9 ]
2-<2-(diethylamino)ethoxy>ethyl 1-(4-methoxyphenyl)-1-cyclopentanecarboxylate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1994,vol. 37,p. 2285 - 2291

36
[ 140-82-9 ]
[ 162733-01-9 ]
2-<2-(diethylamino)ethoxy>ethyl 1-(3,4-dichlorophenyl)-1-cyclohexanecarboxylate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1994,vol. 37,p. 2285 - 2291

37
[ 140-82-9 ]
(+-)-3-<2>furyl-2-phenyl-propionic acid methyl ester [ No CAS ]
[ 102759-49-9 ]

Reference： [1]Patent: US2842585,1954,

38
[ 140-82-9 ]
(+-)-4-<cyclohexyl-(4-methoxy-phenyl)-methyl>-piperazine-1-carboxylic acid ethyl ester [ No CAS ]
[ 115605-92-0 ]

Reference： [1]Patent: US2842585,1954,

39
[ 140-82-9 ]
(+-)-2-phenyl-3-<2>thienyl-propionyl chloride (C₁₃H₁₁ClOS) [ No CAS ]
[ 115214-32-9 ]

Reference： [1]Patent: US2842585,1954,

42
[ 100-35-6 ]
monosodium compound of ethylene glycol [ No CAS ]
[ 140-82-9 ]

Reference： [1]Patent: DE398010,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 14,p. 1420

43
[ 140-82-9 ]
2-isopropoxy-quinoline-4-carbonyl chloride [ No CAS ]
2-isopropoxy-quinoline-4-carboxylic acid-[2-(2-diethylamino-ethoxy)-ethyl ester]; hydrochloride [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 495

44
[ 52432-72-1 ]
[ 5465-28-1 ]
[ 140-82-9 ]

Reference： [1]Il Farmaco,2005,vol. 60,p. 689 - 699

45
[ 140-82-9 ]
(2S,3R)-3-Phenyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid 2-(2-diethylamino-ethoxy)-ethyl ester; compound with 3-carboxy-3-hydroxy-pentanedioic acid [ No CAS ]

Reference： [1]Farmaco, Edizione Scientifica,1981,vol. 36,p. 932 - 941

46
[ 140-82-9 ]
[ 136089-19-5 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

47
[ 140-82-9 ]
[ 136089-22-0 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

48
[ 140-82-9 ]
[ 136089-24-2 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

49
[ 140-82-9 ]
[ 136089-23-1 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

50
[ 140-82-9 ]
[ 136089-20-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

51
[ 140-82-9 ]
[ 136089-21-9 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 3159 - 3164

52
[ 140-82-9 ]
[ 132984-17-9 ]

Reference： [1]Journal of Pharmacy and Pharmacology,1960,vol. 12,p. 137T-152T

53
[ 947322-40-9 ]
[ 140-82-9 ]
2'-O-[2(2-N,N-diethylaminoethoxy)ethyl]-5-methyl uridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With borane; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran;	EXAMPLE 13 2'-O-[2(2-N,N-diethylaminoethoxy)ethyl]-5-methyl uridine 2[2-(Diethylamino)ethoxy]ethanol (50 mmol) is slowly added to a solution of borane in tetrahydrofuran (1 M, 10 mL, 10 mmol) with stirring in a 100 mL bomb. Hydrogen gas evolves as the solid dissolves O2-2'-anhydro-5-methyluridine (1.2 g, 5 mmol), and sodium bicarbonate (2.5 mg) are added and the bomb is sealed, placed in an oil bath and heated to 155° C. for 26 hours. The bomb is cooled to room temperature and opened. The crude solution is concentrated and the residue partitioned between water (200 mL) and hexanes (200 mL). The excess alcohol is extracted into the hexane layer. The aqueous layer is extracted with ethyl acetate (3*200 mL) and the combined organic layers are washed once with water, dried over anhydrous sodium sulfate and concentrated. The residue is columned on silica gel using methanol/methylene chloride 1:20 (which has 2percent triethylamine) as the eluent. The appropriate column fractions are concentrated and concentrated to give the title compound.

Reference： [1]Patent: US6600032,2003,B1

54
[ 75-07-0 ]
[ 929-06-6 ]
[ 140-82-9 ]

Yield	Reaction Conditions	Operation in experiment
	With NaBH3CN; In methanol; water;	EXAMPLE 12 2-[2-(diethylamino)ethoxy] ethanol 2-(2-aminoethoxy)ethanol (Aldrich 0.5 mmol) is treated with NaBH3CN (Aldrich, 200 mg, 3.0 mmol) in 50percent aqueous methanol (30 mL). To this solution, acetaldehyde 95percent purity (2 mL, 17 mmol) is added in one portion and the mixture is heated at 50° C. for 2 days in a flask under argon. After removal of the solvent under reduced pressure, the residue is dissolved in water, extracted with ethylacetate to give the title compound.
	With NaBH3CN; In methanol; water;	EXAMPLE 12 2-[2-(diethylamino)ethoxy] Ethanol 2-(2-aminoethoxy)ethanol (Aldrich 0.5 mmol) is treated with NaBH3CN (Aldrich, 200 mg, 3.0 mmol) in 50percent aqueous methanol (30 mL). To this solution, acetaldehyde 95percent purity (2 mL, 17 mmol) is added in one portion and the mixture is heated at 50° C. for 2 days in a flask under argon. After removal of the solvent under reduced pressure, the residue is dissolved in water, extracted with ethylacetate to give the title compound.

Reference： [1]Patent: US6600032,2003,B1
[2]Patent: US2004/9938,2004,A1

55
[ 140-82-9 ]
[ 79611-69-1 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; In benzene;	Step C 2-(2-Diethylaminoethoxy)-ethyl Chloride A modification of the procedure described in J. Am. Chem. Soc. 76:3163 (1954) was used to obtain this compound, beginning with the dropwise addition of thionyl chloride (17.02 mL, 233.42 mmol) to a solution of 2-(2-di-ethylaminoethoxy)-ethanol in benzene (100 mL). The reaction mixture was stirred at reflux for 1.5 hours and the volatiles were removedunder diminished pressure. The oily residue crystallized in ether, was nearly homogeneous by TLC, and was used without further purification. The HCl salt obtained in this reaction was very hygroscopic. Attempts at purification of the free base via distillation resulted in decomposition. CIMS 180 m/z (M+1), 183 m/z (M+3).

Reference： [1]Patent: US5331010,1994,A

56
[ 79-03-8 ]
[ 140-82-9 ]
[ 868845-26-5 ]

Yield	Reaction Conditions	Operation in experiment
56%	With triethylamine; In dichloromethane; at 20℃; for 20.0h;	Various compounds according to the invention were prepared according to the synthetic scheme below: This process comprises the following stages. Commercial ((diethylamino)ethoxy)ethanol is dissolved in dichloromethane. Subsequently, 2.1 equivalents of triethylamine and then, slowly, 1.05 equivalents of acid chloride RCOCl are added and the reaction mixture is left to react at ambient temperature for 20 h. The medium is diluted with dichloromethane and then two aqueous washing operations are carried out. The organic phase is dried over sodium sulphate, filtered and then concentrated to dryness. The residue obtained is purified by a silica column or by precipitation.The reactant (acyl chloride) used and the results obtained are collated in the table below. 1H NMR R Yield Appearance 500 MHz C2H5 56percent Slightly brown oil Conforms C7H15 60percent Slightly brown oil Conforms C9H19 72percent Slightly brown oil Conforms C11H23 82percent Slightly brown oil Conforms C13H27 80percent Slightly brown oil Conforms C15H31 80percent Slightly brown oil Conforms C17H35 44percent Slightly brown oil Conforms C21H43 44percent Beige waxy solid Conforms

Reference： [1]Patent: US2008/287537,2008,A1 .Location in patent: Page/Page column 5-6

57
[ 19333-10-9 ]
[ 140-82-9 ]
bis{2-[2-(diethylamino)ethoxy]ethoxy}silicon(IV) phthalocyanine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
18.9%	With sodium hydride; In toluene; at 20℃;Inert atmosphere;	Compound 11-2 (140 mg, 0.87 mmol), compound 1-6 (265 mg, 0.43 mmol) and sodium hydride (70 mg, 1.75 mmol, 60percent w/w) were added into a 100 mL reaction flask, then toluene (20 mL) was added to the reaction system. The atmosphere of the reaction system was changed to a nitrogen atmosphere using nitrogen ball and the reaction was performed at room temperature and monitored by TLC. After TLC showed that compound 1-6 was completely conversed, the reaction system was concentrated under reduced pressure, then 10 mL of water was added to the reaction system, and the resulting mixture was extracted three times with ethyl acetate (10 mL). The extract liquid was combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography, with an eluent of ammoniated dichloromethane:methanol=100/3-50/1, to obtain the target product 11 (70 mg, 18.9percent) as a deep blue solid. 1H NMR (500 MHz, CDCl3): delta 9.63-9.61 (m, 8H), 8.34-8.32 (m, 8H), 1.91-1.88 (m, 8H), 1.63 (t, J=5 Hz, 4H), 1.47 (t, J=5 Hz, 4H), 0.57 (t, J=5 Hz, 12H), 0.35-0.33 (m, 4H), ?1.91-?1.94 (m, 4H); HRMS: 883.3833 [M+Na]+.

Reference： [1]Patent: US2017/2028,2017,A1 .Location in patent: Paragraph 0122; 0124

58
[ 118591-58-5 ]
[ 109-89-7 ]
[ 140-82-9 ]

Yield	Reaction Conditions	Operation in experiment
42%	With potassium carbonate; In 1,4-dioxane; at 70℃;	Compound 1-3 (2.6 g, 10 mmol) was dissolved in 1,4-dioxane (40 mL), followed by addition of diethylamine 11-1 (2.2 g, 30 mmol), and potassium carbonate (2.76 g, 20 mmol) was added under stirring, followed by stirring the reaction overnight under conditions of 70° C. and a closed reaction system, TLC monitoring showed that the starting material 1-3 was completely reacted. The solvent was removed under reduced pressure to obtain a concentrated residue. The concentrated residue was dispensed with dichloromethane (20 mL), an appropriate amount of silica gel was added and the sample was stirred, spin-dried under reduced pressure and directly placed on a silica gel column for column chromatographic purification, with an eluent (dichloromethane:methanol=20/1-5/1) to obtain the target product 11-2 (0.68 g, 42percent) as a pale yellow oil, LC-MS: m/z=162[M+H]+.

Reference： [1]Patent: US2017/2028,2017,A1 .Location in patent: Paragraph 0122; 0123

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 140-82-9 ] {[proInfo.proName]}

Quality Control of [ 140-82-9 ]

Related Doc. of [ 140-82-9 ]

Product Details of [ 140-82-9 ]

Calculated chemistry of [ 140-82-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 140-82-9 ]

Application In Synthesis of [ 140-82-9 ]

[ 140-82-9 ] Synthesis Path-Downstream 1~58

Related Functional Groups of [ 140-82-9 ]

Aliphatic Chain Hydrocarbons

Ethers

Alcohols

Amines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 140-82-9 ]