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[ CAS No. 1408075-48-8 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 1408075-48-8
Chemical Structure| 1408075-48-8
Chemical Structure| 1408075-48-8
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Product Details of [ 1408075-48-8 ]

CAS No. :1408075-48-8 MDL No. :MFCD23105988
Formula : C7H12O3 Boiling Point : -
Linear Structure Formula :- InChI Key :KFLCCZPFOPDGLN-UHFFFAOYSA-N
M.W : 144.17 Pubchem ID :45090007
Synonyms :

Safety of [ 1408075-48-8 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1408075-48-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1408075-48-8 ]

[ 1408075-48-8 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 23002-51-9 ]
  • [ 1408075-48-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
494 mg With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 1.5h; 70.1 Step 1. Preparation of cis-methyl 3-(6-chloropyrazolo[3,4-d]pyrimidin-1-yl)-1- methyl-cyclobutanecarboxylate. Prepared according to general procedure D using 6-chloro-1H- pyrazolo[3,4-d]pyrimidine (700 mg, 4.5 mmol), cis-methyl 3-hydroxy-1-methyl- cyclobutanecarboxylate (780 mg, 5.4 mmol), and triphenylphosphine (1.8 g, 6.8 mmol) in a solution of THF (23 mL). DIAD (1.3 mL, 6.8 mmol) added dropwise over 30 min. The reaction was stirred at rt for 1.5 h. The reaction mixture was quenched with water and brine then extracted with EtOAc. The combined organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was adsorbed onto silica gel then purified silica gel chromatography (0-20% EtOAc in hexanes) to afford the title compound (494 mg).
494 mg With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 1.5h; 70.1 Step 1. Preparation of cis-methyl 3-(6-chloropyrazolo[3,4-d]pyrimidin-1-yl)-1- methyl-cyclobutanecarboxylate. Prepared according to general procedure D using 6-chloro-1H- pyrazolo[3,4-d]pyrimidine (700 mg, 4.5 mmol), cis-methyl 3-hydroxy-1-methyl- cyclobutanecarboxylate (780 mg, 5.4 mmol), and triphenylphosphine (1.8 g, 6.8 mmol) in a solution of THF (23 mL). DIAD (1.3 mL, 6.8 mmol) added dropwise over 30 min. The reaction was stirred at rt for 1.5 h. The reaction mixture was quenched with water and brine then extracted with EtOAc. The combined organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was adsorbed onto silica gel then purified silica gel chromatography (0-20% EtOAc in hexanes) to afford the title compound (494 mg).
  • 2
  • [ 1408075-48-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C 2: Cs2CO3; [1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride / ethylene glycol dimethyl ether / 3 h / 80 °C
  • 3
  • [ 1408075-48-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C 2: Cs2CO3; [1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride / ethylene glycol dimethyl ether / 3 h / 80 °C 3: lithium hydroxide monohydrate / methanol / 96 h
  • 4
  • [ 1408075-48-8 ]
  • [ 2839520-91-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 - 20 °C
  • 5
  • [ 1408075-48-8 ]
  • [ 2839518-06-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 - 20 °C 3: Cs2CO3; [1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride / ethylene glycol dimethyl ether / 3 h / 80 °C
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