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CAS No. : | 14148-44-8 | MDL No. : | MFCD08693107 |
Formula : | C10H10N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | NVDZAZXIBALFGT-UHFFFAOYSA-N |
M.W : | 158.20 | Pubchem ID : | 12270074 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | UN#: | |
Hazard Statements: | H315-H319 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With ammonium chloride In ethanol at 200℃; for 20h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8-Hydroxychinolin (VI), Dimethylamin; | ||
8-Aminochinolin, CH3I; | ||
8-Formamidochinolin, LiAlH4; |
8-Chinolinol, m. SO2 behandelte 33percentig. wss. Methylaminlsg. (3d, Kochen, pH 6); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium bromide; calcium chloride; copper dichloride at 185℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | In chloroform boiling equimolar amts. for 5 min; addn. of petroleum ether, crystn. (freezer, 1 h), recrystn. (MeOH/CHCl3=1:5); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | In chloroform boiling equimolar amts. for 5 min; addn. of petroleum ether, crystn. (freezer, 1 h), recrystn. (MeOH/CHCl3=1:5); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | With pyridine; copper diacetate In 1,4-dioxane for 2h; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 8-(N-methylamino)quinoline; nickel dichloride In hexane Stage #2: trimethylaluminum In hexane for 0.5h; | 1 To a stirring slurry of 1.30 g (0.01 mole) anhydrous NiCl2 in 50 mL of hexane, 1.58 g (0.01 mole) 8-(methylamino)quinoline is added in portions over a period of twenty minutes. The mixture is allowed to stir overnight and 50 mL (0.1 mole) of trimethyl aluminum (2.0 M in hexane) is added over a period of 30 minutes. The expected active component is: which is used “as is.” |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 8% 2: 82% | Stage #1: 8-amino quinoline With sodium hydride; dimethyl sulfate In tetrahydrofuran at 75℃; for 24h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 20℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium carbonate |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: sodium carbonate 2: hydrogenchloride / ethanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With potassium phosphate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine In 1,4-dioxane; <i>tert</i>-butyl alcohol at 110℃; Inert atmosphere; Glovebox; chemoselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 12h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | With pyridine at 25℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; | |
62% | Stage #1: 8-amino quinoline With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 24h; | |
61% | In ethanol for 20h; Reflux; |
61% | With potassium carbonate In N,N-dimethyl-formamide at 25℃; | |
60% | With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; | |
31% | In ethanol at 0℃; for 20h; Reflux; | |
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 24h; Sealed tube; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With potassium carbonate; copper(I) bromide In 1,2-dichloro-ethane at 100℃; for 12h; Inert atmosphere; Sealed tube; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 29% 2: 43% | With potassium carbonate In acetone at 20℃; for 20h; Sealed tube; Inert atmosphere; Irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With trifluorormethanesulfonic acid In 1,2-dichloro-ethane at 25 - 90℃; for 70h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | In methanol at 20℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 8-amino quinoline; formaldehyd With sodium methylate In methanol for 4h; Reflux; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol for 2h; Reflux; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21% | With copper(l) iodide; sodium carbonate In para-xylene at 120℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With potassium <i>tert</i>-butylate; C49H50Cl2Ir2N5O(1+)*F6P(1-) at 130℃; for 4h; | |
92% | With C31H30ClIrN3O(1+)*F6P(1-); potassium <i>tert</i>-butylate at 130℃; for 12h; | |
43% | With rhodium(III) chloride hydrate; potassium <i>tert</i>-butylate at 150℃; for 48h; Sealed tube; High pressure; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With pyridine; tert.-butylhydroperoxide; iodine In decane; water at 20℃; for 3h; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With triethylamine In dichloromethane at 0 - 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With palladium 10% on activated carbon; potassium <i>tert</i>-butylate at 130℃; for 20h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With tert.-butylhydroperoxide; iodine In acetonitrile at 50℃; for 0.5h; Green chemistry; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With potassium carbonate; potassium iodide In acetonitrile Reflux; | 4.1.10 General procedure for the synthesis of 19a-c General procedure: A mixture of N-methylquinolin-8-amine (3mmol, 1.0eq.), 18a/b/c (1.2eq.), KI (0.1eq.) and K2CO3 (2.0eq.) in CH3CN (10mL) was stirred at reflux overnight. The reaction solution was evaporated to remove most of CH3CN. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=100/1/1) to give the desired product.4.1.10.1 N-((6-Chloro-2-ethylpyrimidin-4-yl)methyl)-N-methylquinolin-8-amine (19a) (0040) Compound 19a was obtained as a yellow oil (yield 67%). 1H NMR (400MHz, CDCl3) δ 8.74 (d, J=2.8Hz, 1H), 8.11 (d, J=8.0Hz, 1H), 7.61 (s, 1H), 7.46-7.34 (m, 3H), 7.11 (d, J=7.2Hz, 1H), 4.86 (s, 2H), 3.05 (s, 3H), 2.95 (q, J=7.6Hz, 2H), 1.36 (q, J=7.6Hz, 3H). 13C NMR (150MHz, CDCl3) δ 172.7, 171.9, 161.4, 148.3, 147.7, 142.3, 136.6, 129.9, 126.8, 121.1, 120.6, 117.2, 115.4, 61.7, 41.0, 32.6, 12.8. MS (ESI/APCI) m/z 312.8 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | With potassium carbonate; potassium iodide In acetonitrile Reflux; | 4.1.10 General procedure for the synthesis of 19a-c General procedure: A mixture of N-methylquinolin-8-amine (3mmol, 1.0eq.), 18a/b/c (1.2eq.), KI (0.1eq.) and K2CO3 (2.0eq.) in CH3CN (10mL) was stirred at reflux overnight. The reaction solution was evaporated to remove most of CH3CN. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=100/1/1) to give the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25% | With potassium carbonate; potassium iodide In acetonitrile Reflux; | 4.1.10 General procedure for the synthesis of 19a-c General procedure: A mixture of N-methylquinolin-8-amine (3mmol, 1.0eq.), 18a/b/c (1.2eq.), KI (0.1eq.) and K2CO3 (2.0eq.) in CH3CN (10mL) was stirred at reflux overnight. The reaction solution was evaporated to remove most of CH3CN. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=100/1/1) to give the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With potassium carbonate; potassium iodide In acetonitrile Reflux; | 4.1.6 N-((6-Chloro-2-methylpyrimidin-4-yl)methyl)-N-methylquinolin-8-amine (10) A mixture of 9 (890mg, 5.0mmol), N-methylquinolin-8-amine (530mg, 3.4mmol), KI (56mg, 0.34mmol) and K2CO3 (925mg, 6.7mmol) in CH3CN (20mL) was stirred at reflux overnight. The reaction solution was evaporated to remove most of CH3CN. The residue was purified by silica gel column chromatography (dichloromethane/methanol=100/1) to give the desired product (1.04g, 98%) as a yellow oil. 1H NMR (400MHz, CDCl3) δ 8.75 (d, J=2.4Hz, 1H), 8.13 (d, J=8.4Hz, 1H), 7.67 (s, 1H), 7.48-7.34 (m, 3H), 7.14 (d, J=7.6Hz, 1H), 4.83 (s, 2H), 3.04 (s, 3H), 2.72 (s, 3H). 13C NMR (150MHz, CDCl3) δ 171.9, 168.4, 161.4, 148.1, 147.7, 142.0, 136.9, 129.9, 126.9, 121.2, 120.8, 117.1, 115.7, 61.7, 41.1, 25.9. MS (ESI/APCI) m/z 298.8 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
13% | With 1,1,1-tri(hydroxymethyl)propane; potassium iodide In water Reflux; | 4.1.34 N-((5-Fluoro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)methyl)-N-methylquinolin-8-amine (52) A mixture of 51 (48mg, 0.2mmol), N-methylquinolin-8-amine (63mg, 0.4mmol), KI (6mg, 0.036mmol) and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol (295mg, 2.2mmol) in water (1mL) was stirred at reflux overnight. The reaction mixture was diluted with saturated NaHCO3 (10mL) and extracted with dichloromethane (20mL×3). The combined organic layer was dried over Na2SO4, filtered and evaporated. The residue was purified by silica gel column chromatography (dichloromethane/methanol=50/1) to give the product (20mg, 13%) as a yellow oil. 1H NMR (400MHz, CDCl3) δ 8.88 (d, J=4.0Hz, 1H), 8.08 (d, J=8.0Hz, 1H), 7.44-7.29 (m, 3H), 7.01 (s, 1H), 4.95 (s, 2H), 3.67-3.48 (m, 4H), 3.06 (s, 3H), 2.47-2.32 (m,7H), 2.26 (s, 3H). 13C NMR (150MHz, CDCl3) δ 161.3 (d, J=8.6Hz), 151.4 (d, J=5.1Hz), 150.7 (d, J=15.6Hz), 148.8, 147.7, 143.9 (d, J=255.2Hz), 142.9, 136.4, 129.5, 126.4, 120.9, 120.8, 117.3, 55.0, 46.2, 46.0, 45.9, 40.9, 25.5 (d, J=1.8Hz). HRMS (ESI): calcd for C21H26FN6 [M+H]+ 381.2197, found 381.2182. Purity: 95.3%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With potassium carbonate; potassium iodide In acetonitrile for 2h; Reflux; | 4.1.37 N-((5,6-Dichloro-2-methylpyrimidin-4-yl)methyl)-N-methylquinolin-8-amine (56) A mixture of 55 (53mg, 0.25mmol), N-methylquinolin-8-amine (40mg, 0.25mmol), KI (5mg, 0.03mmol) and K2CO3 (70mg, 0.50mmol) in CH3CN (10mL) was stirred at reflux for 2h. The reaction mixture was filtered and the filtrate was evaporated. The residue was purified by silica gel column chromatography (dichloromethane/methanol=100/1) to give the desired product (60mg, 72%) as a colorless oil. 1H NMR (400MHz, CDCl3) δ 8.75 (d, J=2.4Hz, 1H), 8.09 (d, J=7.6Hz, 1H), 7.46-7.39 (m, 1H), 7.39-7.32 (m, 2H), 7.16 (d, J=7.2Hz, 1H), 5.24 (s, 2H), 3.25 (s, 3H), 2.60 (s, 3H). 13C NMR (150MHz, CDCl3) δ 167.1, 165.3, 158.0, 148.1, 147.4, 142.1, 136.7, 129.7, 126.7, 125.0, 120.9, 120.4, 116.7, 58.4, 41.6, 25.4. MS (ESI/APCI) m/z 332.7 [M+H] +. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | With potassium carbonate; potassium iodide In acetonitrile for 2h; Reflux; | 4.1.42 tert-Butyl 4-(5-cyano-2-methyl-6-((methyl(quinolin-8-yl)amino)methyl)pyrimidin-4-yl)piperazine-1-carboxylate (62) A mixture of 61 (85mg, 0.24mmol), N-methylquinolin-8-amine (38mg, 0.24mmol), KI (5mg, 0.03mmol) and K2CO3 (70mg, 0.5mmol) in 10mL of MeCN was stirred at reflux for 2h. The reaction solution was cold to room temperature and filtered. The filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (dichloromethane/methanol=100/1) to give the desired product (20mg, 24%) as a yellow oil. 1H NMR (400MHz, CDCl3) δ 8.82 (s, 1H), 8.10 (d, J=7.2Hz, 1H), 7.51-7.34 (m, 3H), 7.09 (s, 1H), 5.12 (s, 2H), 3.82 (s, 4H), 3.67-3.40 (m, 4H), 3.18 (s, 3H), 2.47 (s, 3H), 1.47 (s, 9H). MS (ESI/APCI) m/z 473.9 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With triethylamine In dichloromethane at 0℃; for 3h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
38% | With trimethylamine-borane; sodium hydride at 80℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 20 °C 2: C31H30N2OPt; caesium carbonate / acetonitrile / 10 h / 20 °C / Irradiation; Sealed tube; Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In dichloromethane at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 2.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Stage #1: N-methylquinolin-8-amine; 2-chloromethyl-1H-benzimidazole With potassium iodide In ethanol at 80℃; for 8h; Inert atmosphere; Stage #2: With potassium hydroxide In ethanol at 20 - 80℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: potassium iodide / ethanol / 8 h / 80 °C / Inert atmosphere 1.2: 3 h / 20 - 80 °C / Inert atmosphere 2.1: acetonitrile / 4 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | Stage #1: N-methylquinolin-8-amine; 2-chloromethyl-1-methyl-1H-benzoimidazole With potassium iodide In ethanol at 80℃; for 8h; Inert atmosphere; Stage #2: With potassium hydroxide In ethanol at 20 - 80℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: potassium iodide / ethanol / 8 h / 80 °C / Inert atmosphere 1.2: 3 h / 20 - 80 °C / Inert atmosphere 2.1: acetonitrile / 4 h / 20 °C / Inert atmosphere |