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Chemical Structure| 1414852-68-8 Chemical Structure| 1414852-68-8

Structure of 1414852-68-8

Chemical Structure| 1414852-68-8

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Product Details of [ 1414852-68-8 ]

CAS No. :1414852-68-8
Formula : C12H12BNO5
M.W : 261.04
SMILES Code : O=C1[O-][B+3]2([C-](C3=CC=CC=C3)=O)[O-]C(C[N]2(C1)C)=O

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Application In Synthesis of [ 1414852-68-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1414852-68-8 ]

[ 1414852-68-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 328-70-1 ]
  • [ 1414852-68-8 ]
  • [ 21221-93-2 ]
YieldReaction ConditionsOperation in experiment
57% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; In dichloromethane; water; at 60℃; General procedure: All liquids incorporated into the reaction were degassed prior to addition. To a solution of 1 (1 eq., 50.0 mg, 0.192 mmols) and PdCl2(dppf)•CH2Cl2 (20 mol%, 31.3 mg, 0.0384 mmols) in CH2Cl2 (0.1M, 1.6 mL) was added aryl bromide (1.1 eq., 0.211 mmols) and 3.33M K2CO3 solution (6 eq.,0.958 mmols, 0.27 mL). The mixture is quickly stirred and heated at 60. The mixture would go from a bright red solution to a darkened mixture within minutes of the reaction. Upon confirmation of completion by TLC (typically eluted with 40% to 50% MeCN/CH2Cl2), the mixture is immediately taken off the heat and diluted with 10 mL H2O. The organic mixture is extracted with 3 x 10 mL diethyl ether. The organic extracts are dried over Na2SO4, filtered then concentrated. The crude product is purified by silica gel column chromatography (gradient with ethylacetate/hexanes) to afford 3 as a resin or white powder.
 

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