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[ CAS No. 141567-53-5 ] {[proInfo.proName]}

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Chemical Structure| 141567-53-5
Chemical Structure| 141567-53-5
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Product Details of [ 141567-53-5 ]

CAS No. :141567-53-5 MDL No. :MFCD08703638
Formula : C5H7NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :BGPDSEDYUPFTBI-UHFFFAOYSA-N
M.W : 113.11 Pubchem ID :5324810
Synonyms :

Safety of [ 141567-53-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 141567-53-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 141567-53-5 ]
  • Downstream synthetic route of [ 141567-53-5 ]

[ 141567-53-5 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 141567-53-5 ]
  • [ 113732-84-6 ]
Reference: [1] Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4215 - 4234
[2] Tetrahedron Letters, 1993, vol. 34, # 6, p. 1039 - 1042
[3] Organic Letters, 2008, vol. 10, # 13, p. 2813 - 2816
[4] Organic Process Research and Development, 2008, vol. 12, # 1, p. 88 - 95
[5] Tetrahedron Letters, 1995, vol. 36, # 34, p. 6033 - 6036
[6] Patent: EP1186604, 2002, A1, . Location in patent: Page 110
  • 2
  • [ 10200-43-8 ]
  • [ 113732-84-6 ]
  • [ 141567-53-5 ]
YieldReaction ConditionsOperation in experiment
96% With diisobutylaluminium hydride; sodium fluoride In tetrahydrofuran; methanol; water; toluene A solution of ethyl 2-methyloxazole-4-carboxylate (0.31 g, 2.0 mmol) in tetrahydrofuran (5 mL) was chilled to -65° C. and diisobutylaluminum hydride (4.1 mL of a 1 N solution in toluene, 4.1 mmol) was added dropwise over 15 min.
The solution was allowed to warm to ambient temperature and stir 15 min.
The reaction was chilled to 5° C. and carefully quenched by addition of methanol (2 mL).
The reaction mixture was returned to ambient temperature and water (0.18 mL) was added followed by sodium fluoride 1.68 g).
This mixture was stirred 30 min, then dried with magnesium sulfate and filtered.
The filtrate was concentrated and azeotroped with chloroform to afford 0.215 g (96percent) of 4-hydroxymethyl-2-methyloxazole as a pale oil which had: NMR δ 7.45 (s, 1H), 4.52 (d, J=6 Hz, 2H), 3.41 (br s, 1H), 2.42 (s, 3H).
Reference: [1] Organic Process Research and Development, 2008, vol. 12, # 1, p. 88 - 95
[2] Patent: US6380204, 2002, B1,
  • 3
  • [ 10200-43-8 ]
  • [ 1191-15-7 ]
  • [ 113732-84-6 ]
  • [ 141567-53-5 ]
YieldReaction ConditionsOperation in experiment
96% With sodium fluoride In tetrahydrofuran; methanol; water; toluene A solution of ethyl 2-methyloxazole-4-carboxylate (0.31 g, 2.0 mmol) in tetrahydrofuran (5 mL) was chilled to -65° C. and disobutylaluminum hydride (4.1 mL of a 1 N solution in toluene, 4.1 mmol) was added dropwise over 15 min.
The solution was allowed to warm to ambient temperature and stir 15 min.
The reaction was chilled to 5° C. and carefully quenched by addition of methanol (2 mL).
The reaction mixture was returned to ambient temperature and water (0.18 mL) was added followed by sodium fluoride 1.68 g).
This mixture was stirred 30 min, then dried with magnesium sulfate and filtered.
The filtrate was concentrated and azeotroped with chloroform to afford 0.215 g (96percent) of 4-hydroxymethyl-2-methyloxazole as a pale oil which had: NMR δ 7.45 (s, 1 H), 4.52 (d, J=6 Hz, 2 H), 3.41 (br s, 1 H), 2.42 (s, 3 H).
Reference: [1] Patent: US6306864, 2001, B1,
  • 4
  • [ 87413-09-0 ]
  • [ 141567-53-5 ]
  • [ 113732-84-6 ]
Reference: [1] Patent: US6306864, 2001, B1,
[2] Patent: US6380204, 2002, B1,
  • 5
  • [ 141567-53-5 ]
  • [ 113732-84-6 ]
Reference: [1] Organic Process Research and Development, 2008, vol. 12, # 1, p. 88 - 95
  • 6
  • [ 875553-59-6 ]
  • [ 113732-84-6 ]
  • [ 141567-53-5 ]
Reference: [1] Organic Process Research and Development, 2008, vol. 12, # 1, p. 88 - 95
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