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A solution of copper (II) chloride (173 mg, 1.29 mmol) in acetonitrile (4 mL) was cooled to 0 C., tert-butyl nitrite (199 muL, 1.68 mmol) was added dropwise, and the mixture was stirred at 0 C. for 30 min . A solution of <strong>[116632-57-6]3-bromoquinolin-5-amine</strong> (250 mg, 1.12 mmol) in acetonitrile (4 mL) was added to the reaction solution, and the mixture was stirred at room temperature for 1 hour. 1 N hydrochloric acid was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and the solvent was distilled off. The resulting residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (175 mg, 64%). Light yellow solid