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Chemical Structure| 14191-95-8 Chemical Structure| 14191-95-8
Chemical Structure| 14191-95-8

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4-Hydroxybenzyl cyanide is an endogenous metabolite.

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Product Details of 4-Hydroxybenzyl cyanide

CAS No. :14191-95-8
Formula : C8H7NO
M.W : 133.15
SMILES Code : N#CCC1=CC=C(O)C=C1
MDL No. :MFCD00002383
InChI Key :AYKYOOPFBCOXSL-UHFFFAOYSA-N
Pubchem ID :26548

Safety of 4-Hydroxybenzyl cyanide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332
Precautionary Statements:P280

Application In Synthesis of 4-Hydroxybenzyl cyanide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14191-95-8 ]

[ 14191-95-8 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 14191-95-8 ]
  • [ 162709-84-4 ]
  • C51H85NO4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
91.2% (4) Preparation of intermediate 2 wherein R is n-C12H25, the preparation route is as follows:In a 250 mL two-necked flask, magnetons were charged and 5.0 g (7.36 mmol) was added.3,4,5-tri-dodecyloxybenzyl chloride (X3-2-2), 3.0 g K2CO3 (43.9 mmol), 0.4 g (1.24 mmol) tetrabutylammonium bromide (TBAB), dissolved in 60 mL In acetone,The stirring was turned on and heated to reflux; 1.08 g (8.09 mmol) of p-hydroxyphenylacetonitrile (X3-1)Dissolved in 40 mL of acetone, and slowly added to the reaction system with a constant pressure funnel.After the addition was completed, the mixture was heated to reflux for 12 h, and the progress of the reaction was monitored by a TLC plate. After the reaction was completed, it was cooled to room temperature, filtered, and the residue was washed three times with acetone, dried over anhydrous MgSO 4 and filtered.The obtained filtrate was obtained as a white solid after the solvent was evaporated, and the crude product was purified by column chromatography to afford 5.2 g of Intermediate 2, which was named Y2-2, yield 91%.
 

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