[ CAS No. 141943-04-6 ] {[proInfo.proName]}

Name: 141943-04-6|1-Benzylpiperidine-3-carboxylic acid|97%
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3d Animation Molecule Structure of 141943-04-6

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Quality Control of [ 141943-04-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 141943-04-6 ]

Product Details of [ 141943-04-6 ]

CAS No. :	141943-04-6	MDL No. :	MFCD03086172
Formula :	C₁₃H₁₇NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HGCSHWVOIUCAJN-UHFFFAOYSA-N
M.W :	219.28	Pubchem ID :	16244010
Synonyms :

Calculated chemistry of [ 141943-04-6 ] Expand+

Physicochemical Properties

Num. heavy atoms :	16
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.46
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	66.72
TPSA :	40.54 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.99 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.07
Log Po/w (XLOGP3) :	-0.5
Log Po/w (WLOGP) :	1.45
Log Po/w (MLOGP) :	1.86
Log Po/w (SILICOS-IT) :	1.85
Consensus Log Po/w :	1.35

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.96
Solubility :	23.8 mg/ml ; 0.109 mol/l
Class :	Very soluble
Log S (Ali) :	0.12
Solubility :	287.0 mg/ml ; 1.31 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	-2.68
Solubility :	0.461 mg/ml ; 0.0021 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.87

Safety of [ 141943-04-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 141943-04-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 141943-04-6 ]
Downstream synthetic route of [ 141943-04-6 ]

[ 141943-04-6 ] Synthesis Path-Upstream 1~6

1
[ 141943-03-5 ]
[ 141943-04-6 ]
[ 498-95-3 ]

Reference： [1] Tetrahedron Letters, 1992, vol. 33, # 17, p. 2299 - 2302

2
[ 72551-53-2 ]
[ 141943-04-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With sodium hydroxide In tetrahydrofuran; 1,4-dioxane; water at 20℃;	A 4N-aqueous sodium hydroxide solution (15 ml) was added to a solution of ethyl 1-benzyl-3-piperidinecarboxylate (7.00 g, 28.3 mmol) in a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml), and the resulting mixture was stirred at room temperature for 4 hours. After a 4N-aqueous sodium hydroxide solution (15 ml) was added again, the resulting mixture was stirred overnight at room temperature. After completion of the reaction, the reaction solution was neutralized by the addition of 2N-hydrochloric acid (15 ml) under ice-cooling and the resulting mixture was subjected to azeotropic concentration with toluene. The residue was suspended in ethanol, followed by filtration, and the filtrate was concentrated to obtain 1-benzyl-3-piperidinecarboxylic acid (6.3 g, 100percent).

Reference： [1] Patent: EP1403255, 2004, A1, . Location in patent: Page 66
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 25, p. 5512 - 5532
[3] Patent: WO2008/55959, 2008, A1, . Location in patent: Page/Page column 65

3
[ 141943-03-5 ]
[ 141943-04-6 ]
[ 498-95-3 ]

Reference： [1] Tetrahedron Letters, 1992, vol. 33, # 17, p. 2299 - 2302

4
[ 71962-74-8 ]
[ 141943-04-6 ]

Reference： [1] Journal of Medicinal Chemistry, 2003, vol. 46, # 25, p. 5512 - 5532
[2] Patent: EP1403255, 2004, A1,

5
[ 100-44-7 ]
[ 498-95-3 ]
[ 141943-04-6 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 1, p. 350 - 364

6
[ 100-44-7 ]
[ 141943-04-6 ]

Reference： [1] Patent: EP1403255, 2004, A1,

[ 141943-04-6 ] Synthesis Path-Downstream 1~42

1
[ 141943-03-5 ]
[ 141943-04-6 ]
[ 498-95-3 ]

Reference： [1]Tetrahedron Letters,1992,vol. 33,p. 2299 - 2302

2
[ 141943-04-6 ]
[ 769907-38-2 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

3
[ 72551-53-2 ]
[ 141943-04-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; at 20.0℃;	A 4N-aqueous sodium hydroxide solution (15 ml) was added to a solution of <strong>[72551-53-2]ethyl 1-benzyl-3-piperidinecarboxylate</strong> (7.00 g, 28.3 mmol) in a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml), and the resulting mixture was stirred at room temperature for 4 hours. After a 4N-aqueous sodium hydroxide solution (15 ml) was added again, the resulting mixture was stirred overnight at room temperature. After completion of the reaction, the reaction solution was neutralized by the addition of 2N-hydrochloric acid (15 ml) under ice-cooling and the resulting mixture was subjected to azeotropic concentration with toluene. The residue was suspended in ethanol, followed by filtration, and the filtrate was concentrated to obtain 1-benzyl-3-piperidinecarboxylic acid (6.3 g, 100%).
	With hydrogenchloride; water; for 4h;Heating / reflux;	Step 1: l-Benzylpiperidine-3-carbonyl chloride hydrochloride; [00273] Hydrochloric acid (20 % aq, 100 mL) was added to ethyl l-benzylpiperidine-3- carboxylate (14.2 g, 57.4 mmol) and the mixture heated at reflux for 4 h. The reaction was cooled and concentrated in vacuo to give l-benzylpiperidine-3-carboxylic acid as a pale yellow solid. This solid was dissolved in thionyl chloride and the resulting solution stirred at room temperature for 1 h. Thionyl chloride was removed in vacuo and the resulting solid was slurried in THF and azeotroped to afford the title compound as a pale yellow solid which was used without further purification (17.0 g, quant.).

Reference： [1]Patent: EP1403255,2004,A1 .Location in patent: Page 66
[2]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532
[3]Patent: WO2008/55959,2008,A1 .Location in patent: Page/Page column 65

4
[ 19335-11-6 ]
[ 141943-04-6 ]
C₂₀H₂₂N₄O [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 350 - 364

5
[ 100-44-7 ]
[ 498-95-3 ]
[ 141943-04-6 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 350 - 364

6
[ 100-39-0 ]
XOOC-CH₂-COOX [ No CAS ]
[ 141943-04-6 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

7
[ 141943-04-6 ]
[ 149452-46-0 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

8
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-phenoxy-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

9
[ 141943-04-6 ]
[ 639468-28-3 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

10
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-p-tolyloxy-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

11
[ 141943-04-6 ]
[ 639468-31-8 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

12
[ 141943-04-6 ]
[ 639468-33-0 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

13
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(4-methoxy-phenoxy)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

14
[ 141943-04-6 ]
3-[(4-chloro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

15
[ 141943-04-6 ]
3-[(4-fluoro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

16
[ 141943-04-6 ]
4-[(4-fluoro-phenyl)-piperidin-3-yl-methoxy]-benzonitrile [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

17
[ 141943-04-6 ]
3-[(3,4-dichloro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

18
[ 141943-04-6 ]
3-[(benzo[1,3]dioxol-5-yloxy)-(4-fluoro-phenyl)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

19
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(naphthalen-1-yloxy)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

20
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(4-trifluoromethyl-phenoxy)-methyl]-piperidine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

21
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-phenoxy-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

22
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-p-tolyloxy-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

23
[ 141943-04-6 ]
3-[(4-chloro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

24
[ 141943-04-6 ]
3-[(4-fluoro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

25
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(4-methoxy-phenoxy)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

26
[ 141943-04-6 ]
3-[(4-cyano-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

27
[ 141943-04-6 ]
3-[(3,4-dichloro-phenoxy)-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

28
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(naphthalen-1-yloxy)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

29
[ 141943-04-6 ]
3-[(benzo[1,3]dioxol-5-yloxy)-(4-fluoro-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

30
[ 141943-04-6 ]
3-[(4-fluoro-phenyl)-(4-trifluoromethyl-phenoxy)-methyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

31
[ 141943-04-6 ]
(1-benzylpiperidin-3-yl)(4-fluorophenyl)methanone hydrochloride [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532

32
[ 71962-74-8 ]
[ 141943-04-6 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5512 - 5532
[2]Patent: EP1403255,2004,A1

34
[ 2835-68-9 ]
[ 141943-04-6 ]
[ 609780-65-6 ]

Yield	Reaction Conditions	Operation in experiment
26%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20.0℃;	(c) Synthesis of N-[4-(aminocarbonyl)phenyl]-1-benzylpiperidine-3-carboxamide To a solution of <strong>[141943-04-6]1-benzyl-3-piperidinecarboxylic acid</strong> (1.37 g, 6.23 mmol) in N,N-dimethylformamide (28 ml) were added p-aminobenzamide (0.92 g, 6.54 mmol), triethylamine (1.3 ml, 9.33 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.79 g, 9.34 mmol) and 1-hydroxybenzotriazole monohydrate (0.93 mg, 6.88 mmol) at room temperature, and stirred overnight. Then, the reaction mixture was poured into a saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The organic layer was washed with a saturated aqueous sodium chloride solution and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol = 95/5) to obtain N-[4-(aminocarbonyl)phenyl]-1-benzylpiperidine-3-carboxamide (551 mg, 26%). Melting point: 211-212C.

Reference： [1]Patent: EP1500643,2005,A1 .Location in patent: Page 20

35
[ 141943-04-6 ]
[ 244196-56-3 ]

Yield	Reaction Conditions	Operation in experiment
100%	With thionyl chloride; at 20.0℃; for 1h;	Step 1: l-Benzylpiperidine-3-carbonyl chloride hydrochloride; [00273] Hydrochloric acid (20 % aq, 100 mL) was added to ethyl l-benzylpiperidine-3- carboxylate (14.2 g, 57.4 mmol) and the mixture heated at reflux for 4 h. The reaction was cooled and concentrated in vacuo to give l-benzylpiperidine-3-carboxylic acid as a pale yellow solid. This solid was dissolved in thionyl chloride and the resulting solution stirred at room temperature for 1 h. Thionyl chloride was removed in vacuo and the resulting solid was slurried in THF and azeotroped to afford the title compound as a pale yellow solid which was used without further purification (17.0 g, quant.).

Reference： [1]Patent: WO2008/55959,2008,A1 .Location in patent: Page/Page column 65

36
[ 141943-04-6 ]
[ 75-65-0 ]
[ 478828-62-5 ]

Yield	Reaction Conditions	Operation in experiment
72%		Triethylamine (0.38 ml, 2.73 mmol) and diphenylphosphoryl azide (0.692 g, 2.52 mmol) were added to a solution of <strong>[141943-04-6]1-benzyl-3-piperidinecarboxylic acid</strong> (0.501 g, 2.28 mmol) in toluene (10 ml), and the resulting mixture was stirred for 2 hours with heating under reflux. The solvent was distilled off under reduced pressure and a solution of the resulting residue in tert-butanol (10 ml) was stirred for 4 hours with heating under reflux. The solvent was distilled off under reduced pressure and a 1N-aqueous sodium hydroxide solution was added to the residue, followed by extraction with ethyl acetate (three times). The extract solution was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the residue was purified by a silica gel chromatography (eluent: hexane/ethyl acetate = 5/1) to obtain tert-butyl 1-benzyl-3-piperidinylcarbamate (0.475 g, 72%).

Reference： [1]Patent: EP1403255,2004,A1 .Location in patent: Page 66

37
[ 141943-04-6 ]
N-(3-piperidinyl)-1H-indazole-5-carboxamide [ No CAS ]

Reference： [1]Patent: EP1403255,2004,A1

38
[ 141943-04-6 ]
N-(1-methylpiperidin-3-yl)-1H-indazole-5-carboxamide [ No CAS ]

Reference： [1]Patent: EP1403255,2004,A1

39
[ 141943-04-6 ]
N-(1-benzylpiperidin-3-yl)-1H-indazole-5-carboxamide [ No CAS ]

Reference： [1]Patent: EP1403255,2004,A1

40
[ 141943-04-6 ]
3-amino-1-benzylpiperidine dihydrochloride [ No CAS ]

Reference： [1]Patent: EP1403255,2004,A1

41
[ 100-44-7 ]
[ 141943-04-6 ]

Reference： [1]Patent: EP1403255,2004,A1

42
[ 2835-68-9 ]
[ 141943-04-6 ]
[ 609780-68-9 ]

Reference： [1]Patent: EP1500643,2005,A1

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Isomers

Technical Information

• Acids Combine with Acyl Halides to Produce Anhydrides • Acyl Chloride Hydrolysis • Amide Hydrolysis • Amide Hydrolysis • Anhydride Hydrolysis • Arndt-Eistert Homologation • Carbonation of Organometallics • Carboxylate Salt Formation • Carboxylic Acids React with Alcohols to Form Esters • Decarboxylation of Substituted Propanedioic • Deprotection of Cbz-Amino Acids • Esters Hydrolyze to Carboxylic Acids and Alcohols • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Hunsdiecker-Borodin Reaction • Nitriles Hydrolyze to Carboxylic Acids • Oxidation of Aldehydes Furnishes Carboxylic Acids • Oxidation of Primary Alcohols Furnishes Carboxylic Acids • Passerini Reaction • Peptide Bond Formation with DCC • Periodic Acid Degradation of Sugars • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reduction of Carboxylic Acids by LiAlH4 • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • The Conversion of Carboxylic Acids into Acyl Halides • Ugi Reaction

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P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 141943-04-6 ] {[proInfo.proName]}

Quality Control of [ 141943-04-6 ]

Related Doc. of [ 141943-04-6 ]

Product Details of [ 141943-04-6 ]

Calculated chemistry of [ 141943-04-6 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 141943-04-6 ]

Application In Synthesis of [ 141943-04-6 ]

[ 141943-04-6 ] Synthesis Path-Upstream 1~6

[ 141943-04-6 ] Synthesis Path-Downstream 1~42

Technical Information

Related Functional Groups of [ 141943-04-6 ]

Aryls

Carboxylic Acids

Related Parent Nucleus of [ 141943-04-6 ]

Aliphatic Heterocycles

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 141943-04-6 ]

Related Parent Nucleus of
[ 141943-04-6 ]