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Chemical Structure| 1419590-81-0 Chemical Structure| 1419590-81-0

Structure of 1419590-81-0

Chemical Structure| 1419590-81-0

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Product Details of [ 1419590-81-0 ]

CAS No. :1419590-81-0
Formula : C7H14ClNO
M.W : 163.65
SMILES Code : [H]Cl.O1CCCC12CNCC2
MDL No. :MFCD28502507
InChI Key :RCYSLGBZYBGVFC-UHFFFAOYSA-N
Pubchem ID :86690185

Safety of [ 1419590-81-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1419590-81-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1419590-81-0 ]

[ 1419590-81-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1254036-06-0 ]
  • [ 1419590-81-0 ]
  • [ 1419588-95-6 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20.0℃; <strong>[1419590-81-0]1-oxa-7-azaspiro[4.4]nonane hydrochloride</strong> (65 mg, 0.40 mmol) and TEA (0.082 mL, 0.59 mmol) were mixed with DCM (4 mL). To the mixture was added 4-(1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yloxy)benzaldehyde (0.150 g, 0.40 mmol) dissolved in DCM (1 mL). After stirring for 10 min, sodiumtriacetoxyhydroborate (0.168 g, 0.79 mmol) was added and the reaction mixture was stirred at RT overnight. An aqueous solution of NaHC03 (8%, 10 mL) was added and the mixture was extracted twice with DCM (15 mL). The organic layer was dried over a phase separator and concentrated under reduced pressure. The crude was purified bychromatography on silica gel (25 g) eluting with a mixture of EtOAc and ammonia in MeOH (2M) 20: 1. The pooled fractions were concentrated under reduced pressure yielding the desired compound as a white solid (95 mg, 49%). 1H NMR (400 MHz, CDC13): delta 1.73 (m, 5H), 1.86 (m, IH), 2.57 (m, 3H), 2.69 (m, IH), 3.56 (m, 2H), 3.77 (m, 2H), 3.88 (s, 3H), 4.32 (dd, IH), 4.63 (m, IH), 4.73 (dd, IH), 5.07 (m, 2H), 6.71 (d, 2H), 7.01 (d, 2H), 7.27 (d, 2H), 8.09 (d, 2H). MS (APCI+) m/z 491.5 [M+H]+. LC purity: 94%.
 

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