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Chemical Structure| 1423702-68-4 Chemical Structure| 1423702-68-4

Structure of 1423702-68-4

Chemical Structure| 1423702-68-4

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Product Details of [ 1423702-68-4 ]

CAS No. :1423702-68-4
Formula : C17H23BO5
M.W : 318.17
SMILES Code : O=C(OC)C1(COC1)C2=CC=C(C=C2)B3OC(C)(C(C)(O3)C)C
MDL No. :MFCD30829242

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Application In Synthesis of [ 1423702-68-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1423702-68-4 ]

[ 1423702-68-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1228690-37-6 ]
  • [ 1423702-68-4 ]
  • [ 1423684-87-0 ]
YieldReaction ConditionsOperation in experiment
43% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; In 1,2-dimethoxyethane; for 3h;Reflux; Inert atmosphere; A flask was charged with compound LI-7 (25 mg, 0.0786 mmol), compound LI-8 (31.5 mg, 0.0786 mmol), Na2C03 (13 mg, 0.12 mmol), DME (1 mL) and water (0.2 mL). It was degassed with nitrogen for three times, and then Pd(dppf)Cl2 (3 mg, 0.004 mmol, 0.05 eq) was added thereto. After degassed with nitrogen for additional three minutes, the mixture was heated to reflux for 3 hrs under nitrogen atmosphere. LCMS showed the reaction was completed and the acid product was detected. The reaction mixture was cooled down to room temperature, diluted with water (10 mL), acidified with aq. HC1 (IN) to pH = 4-5, extracted with EtOAc (20 mL x 3). The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by prep-HPLC to afford Compound 80 (10.5 mg, yield: 43%). 1H NMR (CDC13, 300 MHz) delta 7.95-7.70 (m, 3H), 7.64-7.52 (m, 4H), 7.45-7.30 (m, 4H), 7.22-7.09 (m, 2H), 5.86 (brs, 2H), 5.34-5.27 (m, 2H), 5.09-5.02 (m, 2H), 2.22 (s, 3H), 1.62 & 1.42 (double s, 3H). MS (ESI) m/z (M+H)+ 499.4.
 

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