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Chemical Structure| 1427473-70-8 Chemical Structure| 1427473-70-8

Structure of 1427473-70-8

Chemical Structure| 1427473-70-8

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Product Details of [ 1427473-70-8 ]

CAS No. :1427473-70-8
Formula : C9H8FN3
M.W : 177.18
SMILES Code : CN1N=CC(C2=CN=C(F)C=C2)=C1
MDL No. :MFCD28365043

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Application In Synthesis of [ 1427473-70-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427473-70-8 ]

[ 1427473-70-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1480-65-5 ]
  • [ 847818-55-7 ]
  • [ 1427473-70-8 ]
YieldReaction ConditionsOperation in experiment
77% With potassium phosphate; palladium diacetate; XPhos; In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere; Reflux; General procedure: Typical procedure 1: a mixture of <strong>[1480-65-5]5-chloro-2-fluoropyridine</strong> 5a(6.60 g, 50.2 mmol), (1-methyl-1H-pyrazol-4-yl)boronic acid(6.30 g, 50.1 mmol), Pd(OAc)2 (0.46 g, 2.1 mmol), 2-dicyclohexylphosphino-20,40,60-triisopropylbiphenyl (1.99 g, 4.1 mmol), and K3PO4 (26.30 g, 123.7 mmol) in dioxane/water (80 mL/8 mL)was stirred at 100 C under N2 atmosphere until the reaction wascompleted by TLC. After the solution was concentrated underreduced pressure, the product was purified via column chromatographyto afford compound 6a (6.80 g, 77percent). 1H NMR (400 MHz,CDCl3, ppm) d 8.22?8.13 (m, 3H), 7.88 (d, J = 0.4 Hz, 1H), 7.30(d, J = 6.8 Hz, 1H) 3.90 (s, 3H). MS m/z (ESI): [M+H]+ 178.1
 

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