Home Cart Sign in  
Chemical Structure| 143192-31-8 Chemical Structure| 143192-31-8

Structure of Fmoc-Norn(Boc)-OH
CAS No.: 143192-31-8

Chemical Structure| 143192-31-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 143192-31-8 ]

CAS No. :143192-31-8
Formula : C25H30N2O6
M.W : 454.52
SMILES Code : O=C(O)CN(C(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CCCNC(OC(C)(C)C)=O
MDL No. :MFCD04112688

Safety of [ 143192-31-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 143192-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 143192-31-8 ]

[ 143192-31-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 82911-69-1 ]
  • [ 258332-57-9 ]
  • [ 143192-31-8 ]
YieldReaction ConditionsOperation in experiment
61% General procedure: Tert-butyl (5-aminoethyl)carbamate (11.7 g) was dissolved in THF (110 mL), and then Et3N (16 mL, 3.0 equiv) was added to the solution under stirring. The mixture was kept at room temperature (rt) for 10 min. Ethyl bromoacetate (12.24 mL, 1 equiv) was dissolved in THF (100 mL) and added dropwise to the solution under stirring. The mixture was kept at rt for 16 h. The mixture was concentrated in vacuo, and then the residue redissolved in Et2O (300 mL) and filtered. The filtrate was concentrated in vacuo to afford the intermediate ethyl ester (17.65 g) as a colourless oil, which was dissolved in dioxane (100 mL) and MeOH (40 mL). Then, 4M NaOH (18 mL) was added dropwise under stirring. The mixture was kept at rt for 1 h, then concentrated in vacuo, and the residue redissolved in H2O (100 mL). Fmoc-OSu (23.69 g, 1 equiv) was dissolved in warm (45 C) MeCN (170 mL) and added dropwise to the mixture under stirring. The mixture was kept at rt for 16 h, then concentrated in vacuo until it turned turbid. Then EtOAc (300 mL) was added, and the resulting mixture was washed with 10% citric acid (400 mL). The aqueous phase was extracted with EtOAc (2 × 150 mL), and the combined organic phases were washed with H2O (3 × 250 mL), and brine (250 mL). The organic phase was extracted with 10% NaHCO3-10% Na2CO3-dioxane 3:3:2 (4 × 400 mL). The combined aqueous phases were adjusted to pH 2-3 with 4M HCl, extracted with EtOAc (150 mL), then combined, dried over Na2SO4and concentrated in vacuo. The resulting solid was recrystallised from EtOAc (200 mL) and heptane (800 mL) to afford building block17(25.0 g, 77.6%) as a white solid; tR= 6.53 min. (gradient 30-100% B during 10 min).
 

Historical Records