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Chemical Structure| 82911-69-1 Chemical Structure| 82911-69-1
Chemical Structure| 82911-69-1

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Synonyms: N-(Fmoc-oxy)succinimide; FMOC-Succinimide; N-(9-Fluorenylmethoxycarbonyloxy)succinimide

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Product Details of Fmoc-OSu

CAS No. :82911-69-1
Formula : C19H15NO5
M.W : 337.33
SMILES Code : O=C(N1OC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)CCC1=O
Synonyms :
N-(Fmoc-oxy)succinimide; FMOC-Succinimide; N-(9-Fluorenylmethoxycarbonyloxy)succinimide
MDL No. :MFCD00010733
InChI Key :WMSUFWLPZLCIHP-UHFFFAOYSA-N
Pubchem ID :134122

Safety of Fmoc-OSu

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335-H411
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P362+P364-P403+P233-P501
Class:9
UN#:3077
Packing Group:

Application In Synthesis of Fmoc-OSu

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 82911-69-1 ]
  • Downstream synthetic route of [ 82911-69-1 ]

[ 82911-69-1 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 27473-62-7 ]
  • [ 82911-69-1 ]
  • [ 135944-07-9 ]
References: [1] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 224 - 236.
[2] Journal of the American Chemical Society, 2003, vol. 125, # 23, p. 6852 - 6853.
  • 2
  • [ 82911-69-1 ]
  • [ 42294-52-0 ]
  • [ 136050-67-4 ]
References: [1] Journal of Medicinal Chemistry, 1994, vol. 37, # 1, p. 189 - 194.
  • 3
  • [ 82911-69-1 ]
  • [ 136050-67-4 ]
References: [1] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264.
  • 4
  • [ 82911-69-1 ]
  • [ 498-95-3 ]
  • [ 193693-68-4 ]
References: [1] Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 8077 - 8085.
  • 5
  • [ 82911-69-1 ]
  • [ 498-95-3 ]
  • [ 193693-68-4 ]
  • [ 193693-67-3 ]
References: [1] Helvetica Chimica Acta, 2005, vol. 88, # 8, p. 2235 - 2249.
  • 6
  • [ 1197-17-7 ]
  • [ 82911-69-1 ]
  • [ 188715-40-4 ]
References: [1] Patent: US2004/14763, 2004, A1, . Location in patent: Page 17; 18.
  • 7
  • [ 82911-69-1 ]
  • [ 210345-89-4 ]
  • [ 1018899-99-4 ]
References: [1] Tetrahedron Asymmetry, 2008, vol. 19, # 24, p. 2839 - 2849.
[2] Journal of Organic Chemistry, 2003, vol. 68, # 4, p. 1575 - 1578.
[3] Chemistry and Biodiversity, 2012, vol. 9, # 11, p. 2494 - 2506.
  • 8
  • [ 5817-22-1 ]
  • [ 82911-69-1 ]
  • [ 940301-35-9 ]
References: [1] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 6017 - 6021.
  • 9
  • [ 82911-69-1 ]
  • [ 33468-35-8 ]
  • [ 908847-42-7 ]
YieldReaction ConditionsOperation in experiment
98% With sodium hydrogencarbonate In water; acetone for 3 h; This compound was synthesized according to the synthetic scheme described in FIGURE 6. To the solution 6-chloroindole (500 mg, 3.31 mmol, I eq) in acetic acid (10 mL) L-serine (695 mg, 6.62 mmol, 2 eq) and acetic anhydride (3.1 mL, 33.1 mmol, 10 eq) were added and the mixture was stirred under Ar at 73°C for 4 h. The reaction mixture was concentrated to half of the volume, diluted with water and extracted with EtOAc. The organic layers were combined, dried over sodium sulfate and evaporated to yield crude product N°-acetyl-6-chloro-D,L-tryptophan 686 mg, 74percent yield). 111 NMR (500 MHz, CD3OD) 81.91 (s, 3H), 3.15-3.3 1 (m, 2H), 4.67 (t, IH), 6.97 (dd, IH), 7.10 (s, 1H), 7.33 (d, IH), 7.53 (d, IH). The A°-acetyl-6-chloro-D,L-tryptophan (686 mg, 145 mmol) was dissolved in phosphate buffer (50 mL) containing 1 mM CoCl26H2O and pH 8.0. To the reaction mixture acylase I was added (500 mg) and the reaction was stirred at 37°C for 24 h with occasional adjustment of pH to 8.0 with LIOH. The reaction mixture was heated to 60°C for 5 mm, cooled to room temperature and filtered through celite. The filtrate was acidified to pH around 3 using HCI and extracted with EtOAc. The aqueous layer was lyophilized and used as crude product for the next reaction. Estimated yield of 43percent (based on theoretical yield for the Lenantiomer), 125.4 mg. 6-chloro-L-tryptophan (125.4 mg, 0.527 mmol, 1 eq) was dissolved in a water/acetone mixture (1:1, v/v) to which NaHCO3 (88.5 rng, 1.05 mmol, 2 eq) was added. Fmoc-OSu (195.6 rng, 0.58 mmol, 1.1 eq) was dissolved in acetone and added to the reaction mixture portion wise over the course of 3 h. Following reaction completion the acetone was evaporated and the aqueous layer acidified with acetic acid to pH about 3 followed by EtOAc extraction. The organic layers were combined, dried over sodium sulfate and evaporated. The crude product was purified with flash column chromatography and solvent system hexanes:EtOAc:AcOH (10:9:1) to yield pure Fmoc-6-chloro-L-tryptophan (237 mg, 98percent). ‘H NMR (500 MHz, CD3OD), 83.16-3.32 (m, 211), 4.65 (t, 1H), 6.98 (dd, 1H), 7.12 (s, 1H), 7.3- 7.55 (m, 8H), 7.79 (d, 211). MS (ESI) calculated for C26H21C1N204 [M+Hj: m/z 460.12, found460.4.
References: [1] Patent: WO2015/153761, 2015, A2, . Location in patent: Paragraph 00256.
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 5, p. 2038 - 2046.
  • 10
  • [ 82911-69-1 ]
  • [ 1093645-21-6 ]
References: [1] Organic and Biomolecular Chemistry, 2017, vol. 15, # 3, p. 541 - 544.
  • 11
  • [ 82911-69-1 ]
  • [ 1223105-51-8 ]
References: [1] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7788 - 7799.
 

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