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Chemical Structure| 1432909-92-6 Chemical Structure| 1432909-92-6

Structure of 1432909-92-6

Chemical Structure| 1432909-92-6

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Product Details of [ 1432909-92-6 ]

CAS No. :1432909-92-6
Formula : C11H10ClN3
M.W : 219.67
SMILES Code : NC1=CC=C(C2=NC=CN=C2C)C=C1Cl
MDL No. :MFCD28506263

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1432909-92-6 ]

[ 1432909-92-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 95-58-9 ]
  • [ 721960-43-6 ]
  • [ 1432909-92-6 ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In tetrahydrofuran; water; toluene; at 100℃; for 15h; A mixture of 2-chloro-3-methylpyrazine (5 g, 38.89 mmol), KOAc (7.62 g, 77.78 mmol), <strong>[721960-43-6]2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline</strong> (11.11 g, 50.56 mmol) and Pd(dppf)Cl2(1 g, 0.1 eq) in toluene/THF/H2O (2:2:1, 70 mL) was stirred at 100 C. for 15 hr. The reaction mixture was diluted with H2O (30 mL), extracted with dichloromethane (2*30 mL). All of the organic layers were combined, washed with brine (2*20 mL), dried over anhydrous Na2SO4, filtered and concentrated. The crude mixture was purified by silica gel column chromatography (ethyl acetate:PE=1:1) to afford the desired product 11 (3 g). LCMS m/z 220 (M+H)+
 

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