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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
USD 200+
Structure of 14331-54-5 * Storage: {[proInfo.prStorage]}
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
2
[ 289-95-2 ]
[ 64-19-7 ]
[ 3438-46-8 ]
[ 5053-43-0 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
3
[ 289-95-2 ]
[ 67-68-5 ]
[ 3438-46-8 ]
[ 5053-43-0 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
[ 22114-27-8 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
4
[ 46118-95-0 ]
[ 544-97-8 ]
[ 14331-54-5 ]
Reference:
[1] Journal of the American Chemical Society, 1999, vol. 121, # 40, p. 9449 - 9450
5
[ 74356-36-8 ]
[ 14331-54-5 ]
Yield
Reaction Conditions
Operation in experiment
49%
at 160℃; for 4 h; Neat (no solvent)
Reference Example 78 2,4-dimethylpyrimidine 2,4-Dimethyl-5-pyrimidinecarboxylic acid was heated at 160°C for 4 hrs. The reaction mixture was distilled under atmospheric pressure to give the title compound (17 g, yield 49percent). boiling point 152-153°C. 1H-NMR(CDCl3)δ: 2.50 (3H, s), 2.70 (3H, s), 6.98 (1H, d, J= 5.1Hz), 8.49 (1H, d, J= 5.1Hz).
Reference:
[1] Journal of the American Chemical Society, 1952, vol. 74, p. 3982
7
[ 4187-87-5 ]
[ 124-42-5 ]
[ 14331-54-5 ]
Reference:
[1] Synlett, 2003, # 10, p. 1443 - 1446
8
[ 108-50-9 ]
[ 14331-54-5 ]
[ 694-81-5 ]
Yield
Reaction Conditions
Operation in experiment
17%
for 0.0833333 h; Irradiation
General procedure: Irradiation procedure. The dimethylpyrazine or dimethylpyrimidine was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 Å Hg lamps.
General procedure: Irradiation procedure. The dimethylpyrazine or dimethylpyrimidine was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 Å Hg lamps.
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
13
[ 5053-43-0 ]
[ 75-91-2 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
[ 22114-27-8 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
14
[ 4472-45-1 ]
[ 14331-54-5 ]
Reference:
[1] Chemische Berichte, 1902, vol. 35, p. 1577
[2] Yakugaku Zasshi, 1950, vol. 70, p. 137[3] Chem.Abstr., 1950, p. 5886
15
[ 2226-86-0 ]
[ 14331-54-5 ]
Reference:
[1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 295 - 305
16
[ 5744-65-0 ]
[ 124-42-5 ]
[ 14331-54-5 ]
Reference:
[1] DRP/DRBP Org.Chem.,
17
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 123-32-0 ]
[ 54198-89-9 ]
[ 4472-45-1 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435
18
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 123-32-0 ]
[ 95-89-6 ]
[ 38557-72-1 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435
19
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 4994-86-9 ]
[ 693-98-1 ]
[ 75712-73-1 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435
20
[ 930-61-0 ]
[ 67-66-3 ]
[ 14331-54-5 ]
[ 123-32-0 ]
[ 4472-45-1 ]
[ 108-50-9 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435
21
[ 289-95-2 ]
[ 75-91-2 ]
[ 3438-46-8 ]
[ 5053-43-0 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
[ 22114-27-8 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
22
[ 289-95-2 ]
[ 64-19-7 ]
[ 3438-46-8 ]
[ 5053-43-0 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
23
[ 289-95-2 ]
[ 67-68-5 ]
[ 3438-46-8 ]
[ 5053-43-0 ]
[ 14331-54-5 ]
[ 1558-17-4 ]
[ 22114-27-8 ]
Reference:
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 2, p. 293 - 296
24
[ 14331-54-5 ]
[ 1632-74-2 ]
[ 694-81-5 ]
[ 108-50-9 ]
Yield
Reaction Conditions
Operation in experiment
5.7%
for 0.0833333 h; Irradiation
General procedure: Irradiation procedure. The dimethylpyrazine or dimethylpyrimidine was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 Å Hg lamps.
Reference Example L 78 2,4-dimethylpyrimidine 2,4-Dimethyl-5-pyrimidinecarboxylic acid was heated at 160C for 4 hrs. The reaction mixture was distilled under atmospheric pressure to give the title compound (17 g, yield 49%). b.p.: 152-153C. 1H-NMR(CDCl3)delta: 2.50 (3H, s), 2.70 (3H, s), 6.98 (1H, d, J= 5.1Hz), 8.49 (1H, d, J= 5.1Hz).
49%
at 160℃; for 4.0h;Neat (no solvent);
Reference Example 78 2,4-dimethylpyrimidine 2,4-Dimethyl-5-pyrimidinecarboxylic acid was heated at 160C for 4 hrs. The reaction mixture was distilled under atmospheric pressure to give the title compound (17 g, yield 49%). boiling point 152-153C. 1H-NMR(CDCl3)delta: 2.50 (3H, s), 2.70 (3H, s), 6.98 (1H, d, J= 5.1Hz), 8.49 (1H, d, J= 5.1Hz).
tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran;Heating / reflux;
2-Chloro-4-methyl-pyrimidine. A mixture of 2,6-dichloropyrimidine (1.5 g, 10.07 mmol), trimethylaluminum (0.87 g, 12.08 mmol), tetrakis(triphenylphosphine)palladium(0) (0.81 g, 0.7 mmol) in THF (30 mL) was heated under reflux for several hours. The reultant mixture was quenched with addition of water. (Note: allowing reaction to go overnight was detrimental). The product mixture was extracted with ethyl acetate three times, dried over sodium sulfate, filtered and concentrated to give a dark yellow oil. The resultant oil was purified by flash chromatography on silica gel (hexane/ethyl acetate) to give title compound as a light yellow solid. 1H NMR (400 MHz, DMSO) delta 8.62-8.61 (d, j=5.1 Hz, 1 H), 7.47-7.46 (d, j=5.1 Hz, 1 H), 2.56 (s, 3H).
EXAMPLE XVII 1-Hydroxybenzimidazole-3-Oxide To a mixture containing nitromethane (7.4 g., 0.12 moles), benzofuroxan (13.6 g., 0.10 moles) and tetrahydrofuran (50 ml.) is slowly added <strong>[14331-54-5]dimethylpyrimidine</strong> (11.3 g.) dropwise. The heat of reaction causes the reaction temperature to rise sharply; therefore, an ice-bath is used to maintain a steady rate of reflux. Upon completion of addition, the resulting mixture is allowed to cool to room temperature whereupon the solid product which precipitates is filtered, washed with water, dried and recrystallized from a MeOH/NaOCH3 mixture which is subsequently acidified. The crystalline product has an M.P. 213 C. dec. Analysis: Calc'd. for C7 H6 O2 N2: %C, 56.00; %H, 4.03; %N, 18.66. Found: %C, 56.13; %H, 4.06; %N, 18.77.
under 1 - 1.5 Torr; for 0.08333330000000001h;Irradiation;
General procedure: Irradiation procedure. The dimethylpyrazine or dimethylpyrimidine was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 A Hg lamps.
General procedure: Irradiation procedure. The dimethylpyrazine or <strong>[14331-54-5]dimethylpyrimidine</strong> was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 A Hg lamps.
under 1 - 1.5 Torr; for 0.08333330000000001h;Irradiation;
General procedure: Irradiation procedure. The dimethylpyrazine or dimethylpyrimidine was placed in a Pyrex tube, attached to the vacuum line, and subjected to three freeze-thaw cycles. The remaining material was then allowed to vaporize into a quartz reaction flask (3 L) that had been evacuated overnight. The resulting pressure in the reaction flask ranged from 1.0 to 1.5 Torr. The flask was irradiated for 5 min. in a Rayonet reaction equipped with either 2, 4,6, 8, or 10 low-pressure 2537 A Hg lamps.
propan-2-yl 2-hydroxy-3-(2-methylpyrimidin-4-yl)propanoate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
14%
With iron(II) acetate; In 1,4-dioxane; at 120℃; for 48.0h;Inert atmosphere;
To a solution of <strong>[14331-54-5]2,4-<strong>[14331-54-5]dimethylpyrimidine</strong></strong> (1.00 g, 9.25 mmol) in dioxane (7 ml) was added isopropyl 2- oxoacetate (1.18 g, 10.17 mmol) and diacetoxyiron (80 mg, 0.46 mmol) under nitrogen atmosphere. The mixture was stirred at 120C for 48 h under nitrogen. The solvent was removed under reduced pressure. The residue was purified by FCC (33 - 100 % EtOAc / petrol) to give the title compound as a light brown oil. Y = 14 %. .H NMR (400 MHz, chloroform-/) delta ppm 8.53 (d, J= 5 Hz, 1H), 7.04 (d, J= 5 Hz, 1H), 5.14 - 5.01 (m, 1H), 4.62 - 4.57 (m, 1H), 3.27 - 3.04 (m, 2H), 2.70 (s, 3H), 1.26 - 1.20 (m, 6H).