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Chemical Structure| 144163-74-6 Chemical Structure| 144163-74-6

Structure of 144163-74-6

Chemical Structure| 144163-74-6

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Product Details of [ 144163-74-6 ]

CAS No. :144163-74-6
Formula : C5H9N3S
M.W : 143.21
SMILES Code : NC1=NC(CNC)=CS1

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Application In Synthesis of [ 144163-74-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 144163-74-6 ]

[ 144163-74-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 105806-13-1 ]
  • [ 144163-74-6 ]
  • N-((2-amino-1,3-thiazol-4-yl)methyl)-6-chloro-5-fluoro-2-methyl-4-pyrimidinamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With triethylamine; In tetrahydrofuran; at 20℃; Part B; N-((2-Amino-1,3-thiazol-4-yl)methyl]-6-chloro-5-fluoro-2-methyl-4-pyrimidinamine. 4,6-Dichloro-5-fluoro-2-methylpyrimidine (480 mg, 2.65 mmol) was dissolved in 20 ml. of THF and stirred at room temperature. (4-[(Methylamino)methyl]-1 ,3-thiazol-2-amine (2.65 mmol, theoretical) was added, followed by triethylamine (400 mul_, 2.92 mmol). The resulting reaction mixture was stirred overnight and evaporated. The residue was stirred in water and the solid precipitate was collected by filtration and was dried in vacuo to provide N-[(2-amino-1 ,3-thiazol-4-yl)methyl]-6-chloro-5-fluoro-2-methyl-4-pyrimidinamine (450 mg, 59%) that was used without further purification. LCMS: (M+H)+: 288.1.
 

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