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Chemical Structure| 144256-12-2 Chemical Structure| 144256-12-2

Structure of 144256-12-2

Chemical Structure| 144256-12-2

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Product Details of [ 144256-12-2 ]

CAS No. :144256-12-2
Formula : C18H24O6
M.W : 336.38
SMILES Code : O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@H]3OC3)C=C2
MDL No. :N/A

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Application In Synthesis of [ 144256-12-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 144256-12-2 ]

[ 144256-12-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 154467-16-0 ]
  • [ 144-62-7 ]
  • [ 144256-12-2 ]
  • [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(2S)-2-hydroxy-3-[(2-[(morpholin-4-yl)carbonyl]amino}ethyl)amino]propoxy]phenyl}propanoate oxalate [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% Preparation Example 1the compounds of embodimentTo the reaction flask was added compound 1565.5g, 3000g of water, stirring until the temperature t = 45 , clear solution, 40% sodium hydroxide with 1190g (475g of sodium hydroxide dissolved in 715g of water) was adjusted pH10 ~ 11, the control temperature is low at 50 , a large yellow solid precipitates, the ice bath was cooled to 30 ~ 35 , compound 500g, N, N- dimethylformamide 3000g, incubated at 30 ~ 35 reaction 3 ~ 4h, TLC confirmed that the reaction compound after completion, filtered and the filtrate was extracted 800mL × 3 isopropyl ether, the aqueous layer was collected, extracted with 3000mL × 4 of ethyl acetate, the combined organic layers were washed with brine 5000mL × 3. The organic layer was collected, dried over anhydrous sodium 2000g, charcoal 100g, dried decolorized by stirring 2 ~ 3h. Filtered and the filtrate evaporated to dryness in the vacuum at 60 , the residue was added ethanol 5.0kg, clear solution after stirring was added anhydrous oxalic acid 120g, stirred solution was warmed to clear, and then stirred at normal temperature crystallization, filtration, and dried under reduced pressure as a white crystalline powder 490g, yield 55.0%, HPLC99.8%, single impurity less than 0.1%.
 

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