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Chemical Structure| 1444335-07-2 Chemical Structure| 1444335-07-2

Structure of 1444335-07-2

Chemical Structure| 1444335-07-2

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Product Details of [ 1444335-07-2 ]

CAS No. :1444335-07-2
Formula : C15H18N2O
M.W : 242.32
SMILES Code : NC1=NC(C)=C(OCC2=CC=CC=C2)C(C)=C1C
MDL No. :MFCD30165906

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Application In Synthesis of [ 1444335-07-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1444335-07-2 ]

[ 1444335-07-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1444335-07-2 ]
  • [ 459-04-1 ]
  • N-(5-benzyloxy-3,4,6-trimethylpyridin-2-yl)-2-(4-fluorophenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With triethylamine; In dichloromethane; at 20℃; General procedure: Amide formation: To a solution of 8 (1.0 equiv.) in CH2Cl2 (6 mL per 1.0 mmol of 8) was addedEt3N (1.4 equiv.), acid chloride (1.2 equiv.), and the mixture was stirred at room temperature.The mixture was diluted with CH2Cl2 and the aqueous layer was extracted with CH2Cl2. Thecombined organic solution was washed with saturated sodium bicarbonate, water, and brine.The organic solution was then dried over MgSO4, filtered and the filtrate was concentrated invacuo. The residue was purified by silica gel column chromatography to give 9. Debenzylationmethod1: To a solution of 9 in methanol (10 mL per 1.0 mmol of 9) was added palladium (10%on activated carbon, 20 mg per 100 mg of 9). The mixture was stirred with hydrogen balloonat room temperature. The solid in the reaction mixture was filtered through a Celite pad andthe filtrate was filtered again with a syringe membrane filter. The filtrate was concentrated togive 2. Debenzylation-method 2: To a cooled solution of 9 in CH2Cl2 (10 mL per 1.0 mmol of9) was added pentamethylbenzene (3 equiv.) and 1.0 M BCl3 (2 equiv.) at an ice-bath. Themixture was stirred at iced bath. The reaction mixture was quenched with a solution of 10%methanol in chloroform (1 mL) and stirred for additional 1 h at room temperature. The reactionsolution was concentrated and the residue was purified by silica gel column chromatographyto give 2.
 

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