Home Cart Sign in  
Chemical Structure| 144584-66-7 Chemical Structure| 144584-66-7

Structure of 144584-66-7

Chemical Structure| 144584-66-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 144584-66-7 ]

CAS No. :144584-66-7
Formula : C7H3BrF2O2
M.W : 237.00
SMILES Code : FC1(F)OC2=C(O1)C(Br)=CC=C2
MDL No. :MFCD01631385
InChI Key :LSZYHXNOLVSZHH-UHFFFAOYSA-N
Pubchem ID :2773297

Safety of [ 144584-66-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 144584-66-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 144584-66-7 ]

[ 144584-66-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1583-59-1 ]
  • [ 144584-66-7 ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; bromine; In tetrahydrofuran; hexane; water; STR15 To 15.8 g (0.1 mol) of <strong>[1583-59-1]2,2-difluorobenzodioxole</strong> (compare e.g. DE-OS (German Published Specification) 19 21 741) in 80 ml of absolute tetrahydrofuran are added dropwise under a dry nitrogen atmosphere at -78 C. within 1 hour with stirring 45 ml (0.11 mol) of n-butyllithium (2.5 molar in n-hexane), and after stirring for 1 hour at -78 C. 16 g (0.1 mol) of bromine are then added dropwise with stirring at -78 C. The mixture is stirred for a further 90 minutes at -78 C. then allowed to come to room temperature, and is hydrolyzed with 75 ml of 10 per cent hydrochloric acid. For work-up the organic phase is separated off, washed with 1 normal hydrochloric acid, dried over sodium sulphate, concentrated in vacuo and the residue is distilled in a water pump vacuum. 11.3 g (46% of theory) of 4-bromo-<strong>[1583-59-1]2,2-difluorobenzodioxole</strong> are obtained of boiling point 74 C. to 75 C. at 20 mbar.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 144584-66-7 ]

Fluorinated Building Blocks

Chemical Structure| 33070-32-5

A128809 [33070-32-5]

5-Bromo-2,2-difluorobenzodioxole

Similarity: 0.91

Chemical Structure| 149045-80-7

A521774 [149045-80-7]

5,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxole

Similarity: 0.88

Chemical Structure| 1804876-14-9

A475065 [1804876-14-9]

1,4-Dibromo-2-difluoromethoxy-3-ethoxybenzene

Similarity: 0.83

Chemical Structure| 1037763-48-6

A438039 [1037763-48-6]

4,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxol-5-amine

Similarity: 0.82

Chemical Structure| 1804513-05-0

A638040 [1804513-05-0]

1,5-Dibromo-3-(difluoromethoxy)-2-methoxybenzene

Similarity: 0.81

Bromides

Chemical Structure| 33070-32-5

A128809 [33070-32-5]

5-Bromo-2,2-difluorobenzodioxole

Similarity: 0.91

Chemical Structure| 149045-80-7

A521774 [149045-80-7]

5,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxole

Similarity: 0.88

Chemical Structure| 1804876-14-9

A475065 [1804876-14-9]

1,4-Dibromo-2-difluoromethoxy-3-ethoxybenzene

Similarity: 0.83

Chemical Structure| 1037763-48-6

A438039 [1037763-48-6]

4,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxol-5-amine

Similarity: 0.82

Chemical Structure| 1804513-05-0

A638040 [1804513-05-0]

1,5-Dibromo-3-(difluoromethoxy)-2-methoxybenzene

Similarity: 0.81

Related Parent Nucleus of
[ 144584-66-7 ]

Other Aromatic Heterocycles

Chemical Structure| 33070-32-5

A128809 [33070-32-5]

5-Bromo-2,2-difluorobenzodioxole

Similarity: 0.91

Chemical Structure| 149045-80-7

A521774 [149045-80-7]

5,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxole

Similarity: 0.88

Chemical Structure| 1037763-48-6

A438039 [1037763-48-6]

4,6-Dibromo-2,2-difluorobenzo[d][1,3]dioxol-5-amine

Similarity: 0.82