Home Cart Sign in  
Chemical Structure| 144712-26-5 Chemical Structure| 144712-26-5

Structure of 144712-26-5

Chemical Structure| 144712-26-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 144712-26-5 ]

CAS No. :144712-26-5
Formula : C8H14O3
M.W : 158.20
SMILES Code : CC(C)C(CC(COC)=O)=O
MDL No. :MFCD22578620

Safety of [ 144712-26-5 ]

Application In Synthesis of [ 144712-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 144712-26-5 ]

[ 144712-26-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 108290-86-4 ]
  • [ 144712-26-5 ]
  • ethyl 2-isopropyl-4-(methoxymethyl)pyrrolo[1,2-a]pyrimidine-8-carboxylate [ No CAS ]
  • ethyl 4-isopropyl-2-(methoxymethyl)pyrrolo[1,2-a]pyrimidine-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With acetic acid; at 110℃; for 1h; [00264] To a solution of ethyl 2-amino-lH-pyrrole-3-carboxylate (1.54 g, 10 mmol) in HOAc (10 mL) was added l-methoxy-5-methylhexane-2,4-dione (1.74 g, 11 mmol) at 1 10 C and the mixture was stirred at this temperature for an hour, cooled and concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (PE/EA; 4/1 to 1/1) to give a mixture of ethyl 2-isopropyl-4-(methoxymethyl)pyrrolo[ 1 ,2-a]pyrimidine-8-carboxylate (minor) and ethyl 4-isopropyl-2-(methoxymethyl)pyrrolo[l,2-a]pyrimidine-8-carboxylate (major) (1.1 g, 37%) as a brown solid.
  • 2
  • [ 108290-86-4 ]
  • [ 144712-26-5 ]
  • 2-isopropyl-4-(methoxymethyl)pyrrolo[1,2-a]pyrimidine-8-carboxylic acid [ No CAS ]
  • 4-isopropyl-2-(methoxymethyl)pyrrolo[1,2-a]pyrimidine-8-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
[00265] Following general procedure B, the mixture of esters (1.1 g, 4.0 mmol) produced from the step above afforded a mixture of 2-isopropyl-4-(methoxymethyl)pyrrolo[l,2- a]pyrimidine-8-carboxylic acid and 4-isopropyl-2-(methoxymethyl)pyrrolo[l,2-a]pyrimidine- 8-carboxylic acid (0.62 g, 62%) as a brown solid.
  • 3
  • 5-methyl-5,6,7,8-tetrahydroquinazolin-5-amine [ No CAS ]
  • [ 108290-86-4 ]
  • [ 144712-26-5 ]
  • 2-isopropyl-4-(methoxymethyl)-N-(1-methyl-1,2,3,4-tetrahydroquinazolin-5-yl)pyrrolo[1,2-a]pyrimidine-8-carboxamide [ No CAS ]
  • 4-isopropyl-4-(methoxymethyl)-N-(1-methyl-1,2,3,4-tetrahydroquinazolin-5-yl)pyrrolo[1,2-a]pyrimidine-8-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
1%; 30% [00266] Following general procedure A, 2-isopropyl-4-(methoxymethyl)pyrrolo[l,2- a]pyrimidine-8-carboxylic acid and 4-isopropyl-2-(methoxymethyl)pyrrolo[l,2-a]pyrimidine- 8-carboxylic acid (190 mg, 0.76 mmol) and 5-methyl-5,6,7,8-tetrahydroquinazolin-5-amine afforded 2-isopropyl-4-(methoxymethyl)-N-(l -methyl- 1 ,2,3 ,4-tetrahydroquinazolin-5- yl)pyrrolo[l,2-a]pyrimidine-8-carboxamide (3 mg, 1%) and 4-isopropyl-2-(methoxymethyl)-N- (l-methyl-l,2,3,4-tetrahydroquinazolin-5-yl)pyrrolo[l,2-a]pyrimidine-8-carboxamide (100 mg, 30%) as yellow solids. [00267] 2-Isopropyl-4-(methoxymethyl)-N-( 1 -methyl- 1 ,2,3 ,4-tetrahydroquinazolin-5- yl)pyrrolo[l,2-a]pyrimidine-8-carboxamide: XH NMR (500 MHz, MeOD-i): delta 9.40 (s, 1H), 8.76 (s, 1H), 8.66 (s, 1H), 7.21 (d, J= 3.5 Hz, 1H), 7.14 (d, J= 3.5 Hz, 1H), 6.86 (s, 1H), 4.67 (s, 2H), 3.39 (s, 3H), 3.06-3.02 (m, 1H), 2.92-2.86 (m, 2H), 2.75-2.70 (m, 1H), 2.03-2.00 (m, 1H), 1.94-1.92 (m, 1H) 1.84-1.80 (m, 1H), 1.72 (s, 3H), 1.22 (d, J= 3.0 Hz, 6H). LC-MS m/z: 394.0 [M+H]+. HPLC Purity (214 nm): > 99%; tR = 7.74 minutes. [00268] 4-Isopropyl-2-(methoxymethyl)-N-( 1 -methyl- 1 ,2,3 ,4-tetrahydroquinazolin-5- yl)pyrrolo[l,2-a]pyrimidine-8-carboxamide: 'H NMR (500 MHz, MeOD-i: delta 8.87 (s, 1H), 8.80 (s, 1H), 7.51 (d, J= 3.5 Hz, 1H), 7.32 (d, J= 3.5 Hz, 1H), 6.94 (s, 1H), 4.64 (s, 2H), 3.54 (s, 3H), 3.47-3.44 (m, 1H), 3.05-2.98 (m, 2H), 2.80-2.76 (m, 1H), 2.16-2.15 (m, 1H), 2.10-2.00 (m, 1H), 1.98-1.95 (m, 1H) 1.82 (s, 3H), 1.46 (d, J= 3.0 Hz, 6H). LC-MS m/z: 394.0 [M+H]+. HPLC Purity (214 nm): > 99%; tR = 7.34 minutes. iV-((l.R,4 ?)-4-Butoxycvclohexyl)-4-(methoxymethyl)-2-methylpyrrolo[l,2-alpyrimidine-8- carboxamide
 

Historical Records