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Chemical Structure| 1448-40-4 Chemical Structure| 1448-40-4

Structure of 1448-40-4

Chemical Structure| 1448-40-4

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Product Details of [ 1448-40-4 ]

CAS No. :1448-40-4
Formula : C15H17N3O
M.W : 255.32
SMILES Code : OC1=C(CN(CC2=CC=CC=C2)CC3)C3=NC(C)=N1
MDL No. :MFCD06776713

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Application In Synthesis of [ 1448-40-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1448-40-4 ]

[ 1448-40-4 ] Synthesis Path-Downstream   1~1

  • 1
  • ethanimidamide hydrochloride [ No CAS ]
  • [ 57611-47-9 ]
  • [ 1448-40-4 ]
YieldReaction ConditionsOperation in experiment
50% With sodium methylate; In methanol; at 0 - 40℃;Inert atmosphere; To the solution of <strong>[57611-47-9]methyl 1-benzyl-4-oxopiperidine-3-carboxylate</strong>(2.5 g, 10.1 mmol) in MeOH (15 mL) was added acetamidine hydrochloride(1.2 g, 12.7 mmol) and sodium methoxide (1.4 g, 25.9 mmol)at 0 C under nitrogen atmosphere. The reaction was stirred at 40 C forovernight. After the reaction completed, the solution was removedunder reduced pressure. The residual yellowsolid was dissolved inwater (2 mL) and neutralized with acetic acid. The precipitate was filteredto afford a white solid (1.3 g, 50% yield). 1H NMR (600 MHz,CDCl3) delta (ppm): 12.44 (brs, 2H), 7.44-7.29 (m, 5H), 3.75 (s, 2H), 3.50(s, 2H), 2.85-2.64 (m, 4H), 2.44 (s, 3H). MS-ESI: [M+H]+: 256.5.
 

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