Home Cart 0 Sign in  

[ CAS No. 1448326-17-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1448326-17-7
Chemical Structure| 1448326-17-7
Structure of 1448326-17-7 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1448326-17-7 ]

Related Doc. of [ 1448326-17-7 ]

Alternatived Products of [ 1448326-17-7 ]

Product Details of [ 1448326-17-7 ]

CAS No. :1448326-17-7 MDL No. :MFCD30803856
Formula : C6H8F2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 150.12 Pubchem ID :-
Synonyms :

Safety of [ 1448326-17-7 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501 UN#:1760
Hazard Statements:H315-H318-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1448326-17-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1448326-17-7 ]

[ 1448326-17-7 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 7686-77-3 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: potassium carbonate / acetone / 2 h / 60 °C 2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; water / 3 h / 20 °C 3.1: triethylamine; thionyl chloride / dichloromethane / 0.17 h / 0 °C 4.1: sodium periodate; ruthenium trichloride / water; tetrachloromethane; acetonitrile / 2.5 h / 20 °C 5.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 1 h / 90 °C / Inert atmosphere 5.2: 1 h / 90 °C 6.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 7.1: lithium hydroxide; water / methanol / 0 - 20 °C
  • 2
  • [ 130762-09-3 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; water / 3 h / 20 °C 2.1: triethylamine; thionyl chloride / dichloromethane / 0.17 h / 0 °C 3.1: sodium periodate; ruthenium trichloride / water; tetrachloromethane; acetonitrile / 2.5 h / 20 °C 4.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 1 h / 90 °C / Inert atmosphere 4.2: 1 h / 90 °C 5.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 6.1: lithium hydroxide; water / methanol / 0 - 20 °C
  • 3
  • [ 1448326-12-2 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: triethylamine; thionyl chloride / dichloromethane / 0.17 h / 0 °C 2.1: sodium periodate; ruthenium trichloride / water; tetrachloromethane; acetonitrile / 2.5 h / 20 °C 3.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 1 h / 90 °C / Inert atmosphere 3.2: 1 h / 90 °C 4.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 5.1: lithium hydroxide; water / methanol / 0 - 20 °C
  • 4
  • [ 1448326-14-4 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sodium periodate; ruthenium trichloride / water; tetrachloromethane; acetonitrile / 2.5 h / 20 °C 2.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 1 h / 90 °C / Inert atmosphere 2.2: 1 h / 90 °C 3.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 4.1: lithium hydroxide; water / methanol / 0 - 20 °C
  • 5
  • [ 1448326-15-5 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 1 h / 90 °C / Inert atmosphere 1.2: 1 h / 90 °C 2.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: lithium hydroxide; water / methanol / 0 - 20 °C
  • 6
  • (3R,4R)-methyl 3-fluoro-4-hydroxycyclopentanecarboxylate [ No CAS ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide; water / methanol / 0 - 20 °C
  • 7
  • [ 1448326-16-6 ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
44% With water; lithium hydroxide In methanol at 0 - 20℃; G Step G: (3R,4S)-3,4-difluorocyclopentanecarboxylic acid. To a solution of (3i?,4S)-methyl 3,4- difluorocyclopentanecarboxylate (1 g, 6.1 mmol) in MeOH (5 mL) at 0 °C was added aq. LiOH (4 mL). The mixture was stirred at r.t. for 1 h and then adjusted to pH=2 with 2 N HC1. The resulting mixture was extracted with EtOAc (2 x 20 mL). The combined organic layers were dried over anhydrous MgSC>4 and concentrated. The residue was purified by flash chromatography using EtOAc as eluent to give the desired product as a yellow solid (400 mg, 44% yield).
44% G Step G: Step G: (3R,4S)-3,4-difluorocyclopentanecarboxylic acid To a solution of (3R,4S)-methyl 3,4-difluorocyclopentanecarboxylate (1 g, 6.1 mmol) in MeOH (5 mL) at 0° C. was added aq. LiOH (4 mL). The mixture was stirred at r.t. for 1 h and then adjusted to pH=2 with 2 N HCl. The resulting mixture was extracted with EtOAc (2*20 mL). The combined organic layers were dried over anhydrous MgSO4 and concentrated. The residue was purified by flash chromatography using EtOAc as eluent to give the desired product as a yellow solid (400 mg, 44% yield).
  • 8
  • (3R,4R)-methyl 3-fluoro-4-hydroxycyclopentanecarboxylate [ No CAS ]
  • [ 1448326-17-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: diethylamino-sulfur trifluoride / ethyl acetate; Petroleum ether
Same Skeleton Products
Historical Records