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Structure of 145022-00-0

Chemical Structure| 145022-00-0

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Product Details of [ 145022-00-0 ]

CAS No. :145022-00-0
Formula : C13H17NO
M.W : 203.28
SMILES Code : O=CC1CN(CC2=CC=CC=C2)CCC1
MDL No. :MFCD03086173

Safety of [ 145022-00-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 145022-00-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 145022-00-0 ]

[ 145022-00-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 304-59-6 ]
  • [ 72551-53-2 ]
  • [ 145022-00-0 ]
YieldReaction ConditionsOperation in experiment
With diisobutylaluminium hydride; In methanol; ethyl acetate; toluene; 1.71 N-Benzyl-3-[(N-3-methoxyphenyl-N-phenylsulphonyl)aminomethyl] piperidine DIBAL (7.0 mL, 1.5 M in toluene, 10.5 mmol) was added (dropwise along the sides of the flask) to a solution of <strong>[72551-53-2]ethyl 1-benzylpiperidine-3-carboxylate</strong> in toluene (from Emka-Chemie, 1.01 g, 4.08 mmol) at -78 C. and the resulting solution was stirred at -78 C. for 3.5 hours. The reaction mixture was quenched by slow addition of ethyl acetate (10 mL) and methanol (5 mL) at -78 C. After 15 min, a solution of potassium sodium tartrate (1 M aqueous) was added and the resulting precipitate was stirred for ~1 hour, further diluted with ethyl acetate and filtered to remove the precipitate. The solvent was removed in vacuo, using methanol to aid azeotropic removal of the toluene at the end, providing 1 -benzylpiperidine-3-carboxaldehyde of sufficient purity for use below.
 

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