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Chemical Structure| 1452184-05-2 Chemical Structure| 1452184-05-2

Structure of 1452184-05-2

Chemical Structure| 1452184-05-2

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Product Details of [ 1452184-05-2 ]

CAS No. :1452184-05-2
Formula : C10H12ClFO2S
M.W : 250.72
SMILES Code : O=S(C1=CC=C(C(C)(C)C)C(F)=C1)(Cl)=O
MDL No. :MFCD28614904

Safety of [ 1452184-05-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 1452184-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1452184-05-2 ]

[ 1452184-05-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 835595-11-4 ]
  • [ 1452184-05-2 ]
  • 4-tert-butyl-N-(3,4-dichloro-2-iodophenyl)-3-fluorobenzsulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% [0106] (a) To a solution of <strong>[835595-11-4]3,4-dichloro-2-iodoaniline</strong> (example 2, 2.2 g, 7.67 mmol) in dry pyridine (8 mL) was added 4-tert-butyl-3-fluorophenylsulfonyl chloride (2.11 g, 8.43 mmol) and the reaction mixture was heated at 80 0 C for overnight. LCMS indicated presence of mono and bis-sulfonamides. 10 N aq. NaOH (3 mL) and ethanol (2 mL) were added to hydrolyze the bis-sulfonamide. The reaction mixture was then heated at 80 C for 2 h. It was cooled to r.t, excess solvent was removed in vacuo to afford a dark brown solid, diluted with DCM, washed with IN aq.HCl, and purified by flash column using hexanes: ethyl acetate mixture as an eluent on silica column to get the pure 4-tert-butyl-N-(3,4-dichloro-2- iodophenyl)-3-fluorobenzsulfonamide as an off white solid (3.5 g, 91%)
 

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