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Chemical Structure| 1454303-09-3 Chemical Structure| 1454303-09-3

Structure of 1454303-09-3

Chemical Structure| 1454303-09-3

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Product Details of [ 1454303-09-3 ]

CAS No. :1454303-09-3
Formula : C13H12N2O3
M.W : 244.25
SMILES Code : O=C1C(OC(COC2=CC=CC=C2)=N3)=C3CCN1

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Application In Synthesis of [ 1454303-09-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1454303-09-3 ]

[ 1454303-09-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1454303-09-3 ]
  • [ 37554-70-4 ]
  • [ 1454303-02-6 ]
YieldReaction ConditionsOperation in experiment
72% With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; at 100℃; for 18.0h;Sealed tube; Inert atmosphere; 22. PREPARATION OF 5-(5-FLUORO-4-METHOXY-PYRIMIDIN-2-YL)-2- PHENOXYMETHYL-6,7-DIHYDRO-5H-OXAZOLO[5,4-C] PYRIDIN-4-ONE (EXAMPLE B22). [00522] Palladium (II) acetate (2.78 mg, 0.012 mmol) was added to a stirred suspension of 2-phenoxymethyl-6,7-dihydro-5H-oxazolo[5,4-c]pyridin-4-one (0.1 g, 0.41 mmol), 2-chloro- 5-fluoro-4-methoxy-pyrimidine (0.13 g, 0.82 mmol), cesium carbonate (0.187 g, 0.57 mmol) and 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (0.018 g, 0.037 mmol) in 1,4- dioxane (2 mL) in a sealed tube and under nitrogen. The mixture was stirred at 100 C for 18 h. The solvents were evaporated in vacuo and the crude product was purified by flash column chromatography (silica; EtOAc in DCM 0/100 to 80/20). The desired fractions were collected, the solvents evaporated in vacuo and triturated with diethyl ether to yield the title compound (0.109 g, 72% yield ) as a white solid. d8Hi5FN404. 1H NMR (400 MHz, CDC13) delta ppm 3.07 (t, J= 6.7 Hz, 2 H), 4.08 (s, 3 H), 4.36 (t, J= 6.7 Hz, 2 H), 5.23 (s, 2 H), 6.98 - 7.06 (m, 3 H), 7.28 - 7.36 (m, 2 H), 8.26 (d, J= 2.5 Hz, 1 H).
 

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