Alternatived Products of [ 145575-91-3 ]
Product Details of [ 145575-91-3 ]
CAS No. : | 145575-91-3 |
MDL No. : | |
Formula : |
C5H7BrN2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
175.03
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 145575-91-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 145575-91-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 145575-91-3 ]
- 1
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[ 145575-91-3 ]
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[ 139911-27-6 ]
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2-ethyl-4-(4-fluoro-3-methylphenyl)-1H-imidazole
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
81% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In water; toluene; at 100℃;Inert atmosphere; |
Step 1: A solution of 4-bromo-2-ethyl-1H-imidazole (1.0 g, 5.7 mmol), <strong>[139911-27-6](4-fluoro-3-methylphenyl)boronic acid</strong> (0.97 g, 6.3 mmol), tetrakis(triphenylphosphine)palladium(0) (0.33 g, 0.3 mmol) and aqueous Na2CO3 (2 M, 10 mL, 20 mmol) in toluene (10 ml) was evacuated and then refilled with nitrogen (three cycles). Resulting reaction mixture was then allowed to stir at 100 C. overnight, cooled down to room temperature, dried (MgSO4), filtered and concentrated under reduced pressure to give a black residue. Column chromatography on silica gel, eluting with MeOH/DCM provided 2-ethyl-4-(4-fluoro-3-methylphenyl)-1H-imidazole as a colorless oil (0.95 g, 81%). MS m/e: 205 (M+H)+. |