Home Cart Sign in  
Chemical Structure| 146539-83-5 Chemical Structure| 146539-83-5

Structure of 146539-83-5

Chemical Structure| 146539-83-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 146539-83-5 ]

CAS No. :146539-83-5
Formula : C9H7F3O2
M.W : 204.15
SMILES Code : O=CC1=CC(C(F)(F)F)=CC=C1OC
MDL No. :MFCD03788528
InChI Key :WFRURKYDETYZGF-UHFFFAOYSA-N
Pubchem ID :2779272

Safety of [ 146539-83-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 146539-83-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 146539-83-5 ]

[ 146539-83-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 146137-78-2 ]
  • [ 146539-83-5 ]
YieldReaction ConditionsOperation in experiment
With sodium methylate; acetic acid; In water; (i) 2-Methoxy-5-(trifluoromethyl)benzaldehyde (Compound 4) To a stirred and ice-cooled solution of NaOMe (904 mg, 4.68 mmol) was added 2-fluoro-5-(trifluoromethyl)benzaldehyde (500 mg, 2.60 mmol) portionwise. The dropping funnel employed was washed with THF. The resultant suspension was stirred at room temperature for 5 hr. The reaction mixture was neutralizing for acetic acid (0.3 ml, 5.0 mmol), the solvent was removed. To the solid residue was added water and the mixture was extracted with CH2Cl2. The combined CH2Cl2 extracts were washed with sat. NaHCO3 aq., dried with MgSO4, and concentrated to give crude Compound 4 as a white solid. This was purified with preparative TLC to give pure Compound 4 as a white crystalline (363 mg, 68.4%). 1H-NMR(CDCl3) 10.47(s, 1H), 8.11(d, J=2.2 Hz, 1H), 7.80(dd, J=8.8, 2.2 Hz, 1H), 7.10(d, J=8.8 Hz, 1H), 4.01(s, 3H)
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 146539-83-5 ]

Fluorinated Building Blocks

Chemical Structure| 50823-87-5

A727381 [50823-87-5]

4-Methoxy-3-(trifluoromethyl)benzaldehyde

Similarity: 0.96

Chemical Structure| 1261953-85-8

A304397 [1261953-85-8]

4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 0.93

Chemical Structure| 900641-83-0

A167489 [900641-83-0]

4-(Difluoromethyl)-3-methoxybenzaldehyde

Similarity: 0.91

Chemical Structure| 4864-01-1

A362194 [4864-01-1]

2-Methoxy-5-(trifluoromethyl)benzoic acid

Similarity: 0.90

Chemical Structure| 138490-96-7

A658030 [138490-96-7]

3,4-Dimethoxy-2-(trifluoromethyl)benzaldehyde

Similarity: 0.90

Aryls

Chemical Structure| 50823-87-5

A727381 [50823-87-5]

4-Methoxy-3-(trifluoromethyl)benzaldehyde

Similarity: 0.96

Chemical Structure| 1261953-85-8

A304397 [1261953-85-8]

4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 0.93

Chemical Structure| 900641-83-0

A167489 [900641-83-0]

4-(Difluoromethyl)-3-methoxybenzaldehyde

Similarity: 0.91

Chemical Structure| 4864-01-1

A362194 [4864-01-1]

2-Methoxy-5-(trifluoromethyl)benzoic acid

Similarity: 0.90

Chemical Structure| 138490-96-7

A658030 [138490-96-7]

3,4-Dimethoxy-2-(trifluoromethyl)benzaldehyde

Similarity: 0.90

Aldehydes

Chemical Structure| 50823-87-5

A727381 [50823-87-5]

4-Methoxy-3-(trifluoromethyl)benzaldehyde

Similarity: 0.96

Chemical Structure| 1261953-85-8

A304397 [1261953-85-8]

4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 0.93

Chemical Structure| 900641-83-0

A167489 [900641-83-0]

4-(Difluoromethyl)-3-methoxybenzaldehyde

Similarity: 0.91

Chemical Structure| 138490-96-7

A658030 [138490-96-7]

3,4-Dimethoxy-2-(trifluoromethyl)benzaldehyde

Similarity: 0.90

Chemical Structure| 58914-34-4

A125526 [58914-34-4]

2-Hydroxy-4-(trifluoromethyl)benzaldehyde

Similarity: 0.89

Ethers

Chemical Structure| 50823-87-5

A727381 [50823-87-5]

4-Methoxy-3-(trifluoromethyl)benzaldehyde

Similarity: 0.96

Chemical Structure| 1261953-85-8

A304397 [1261953-85-8]

4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 0.93

Chemical Structure| 900641-83-0

A167489 [900641-83-0]

4-(Difluoromethyl)-3-methoxybenzaldehyde

Similarity: 0.91

Chemical Structure| 4864-01-1

A362194 [4864-01-1]

2-Methoxy-5-(trifluoromethyl)benzoic acid

Similarity: 0.90

Chemical Structure| 138490-96-7

A658030 [138490-96-7]

3,4-Dimethoxy-2-(trifluoromethyl)benzaldehyde

Similarity: 0.90

Trifluoromethyls

Chemical Structure| 50823-87-5

A727381 [50823-87-5]

4-Methoxy-3-(trifluoromethyl)benzaldehyde

Similarity: 0.96

Chemical Structure| 1261953-85-8

A304397 [1261953-85-8]

4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 0.93

Chemical Structure| 4864-01-1

A362194 [4864-01-1]

2-Methoxy-5-(trifluoromethyl)benzoic acid

Similarity: 0.90

Chemical Structure| 138490-96-7

A658030 [138490-96-7]

3,4-Dimethoxy-2-(trifluoromethyl)benzaldehyde

Similarity: 0.90

Chemical Structure| 58914-34-4

A125526 [58914-34-4]

2-Hydroxy-4-(trifluoromethyl)benzaldehyde

Similarity: 0.89