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Chemical Structure| 148254-33-5 Chemical Structure| 148254-33-5

Structure of 148254-33-5

Chemical Structure| 148254-33-5

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Product Details of [ 148254-33-5 ]

CAS No. :148254-33-5
Formula : C6H3ClFIO
M.W : 272.44
SMILES Code : OC1=CC(I)=C(F)C=C1Cl
MDL No. :MFCD22628048

Safety of [ 148254-33-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 148254-33-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 148254-33-5 ]

[ 148254-33-5 ] Synthesis Path-Downstream   1~1

  • 1
  • aqueous potassium iodide [ No CAS ]
  • [ 84478-72-8 ]
  • [ 148254-33-5 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium nitrite; In water; ethyl acetate; Step A 2-Chloro-4-fluoro-5-iodophenol <strong>[84478-72-8]5-Amino-2-chloro-4-fluorophenol</strong> (35 g, previously crystallized from ethyl acetate) was treated with 165 ml of aqueous HCl (6N) and stirred mechanically in a 2 liter flask. The mixture was cooled to 5 C. and treated dropwise with a solution of sodium nitrite (16.6 g) in 80 ml of water while keeping the temperature below 10 C. The mixture was treated dropwise with aqueous potassium iodide (41 g in 100 ml of water). The addition is accompanied by foaming and control of stirring is maintained by the addition of cold water (200 ml) during the course of the iodide addition. The mixture was allowed to come to room temperature and stirred for 1 h. The dark mixture was extracted with ether and washed with sodium thiosulfate sodium. The ether extract was subjected to silica gel chromatography in hexanes/ethyl acetate (15:1) to give a yellow oil (39.8 g).
 

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