Home Cart Sign in  
Chemical Structure| 148400-72-0 Chemical Structure| 148400-72-0

Structure of 148400-72-0

Chemical Structure| 148400-72-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 148400-72-0 ]

CAS No. :148400-72-0
Formula : C15H26O4SSi
M.W : 330.52
SMILES Code : O=S(=O)(OCCO[Si](C)(C)C(C)(C)C)C1=CC=C(C=C1)C
MDL No. :N/A

Safety of [ 148400-72-0 ]

Application In Synthesis of [ 148400-72-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 148400-72-0 ]

[ 148400-72-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1256580-46-7 ]
  • [ 148400-72-0 ]
  • 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5(2-tert-butyldimethylsilylethyl)benzo[b]carbazole-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% With potassium carbonate; In acetonitrile; at 100℃; for 23.0h; Alectinib (50 mg, 0.103 mmol, 1.0 eq.) and anhydrous K2CO3(100 mg, 0.725 mmol, 7.0 eq.) were suspended in dry MeCN(3.5 mL) in a 5-mL v-vial. To this mixture, t-butyldimethylsilylethyltosylate (68 mg, 0.206 mmol, 2.0 eq.) was added, and the reactionmixture was heated at 100 C for 23 h. TLC showed a higher Rf spotin about 75% intensity compared to the starting material. The reactionmixture was cooled to room temperature and filtered; thefiltrate was washed with 5% MeOH/CH2Cl2 (10 mL). The filtrate wasconcentrated under a stream of air, and the crude product waspurified by flash chromatography on silica gel and eluted with 3%MeOH/CH2Cl2 to obtain t-butyldimethylsilylethyl alectinib (compound5) (41 mg, 61% yield) with 96% purity. 5: Rf 0.7 in 5%MeOH/CH2Cl2; 1H NMR (CDCl3, 600 MHz) d: 8.64 (d, J 8.2 Hz, 1H),8.23 (s, 1H), 7.80 (s, 1H), 7.56 (dd, J 7.2 Hz, 1H), 7.17 (s, 1H), 4.65 (t,J 6.3 Hz, 2H), 4.07 (t, J 6.2 Hz, 2H), 3.77 (t, J 4.4 Hz, 4H), 3.31 (d,J 12.1 Hz, 2H), 2.74 (m, J 7.5 Hz, 4H), 2.63 (t, J 4.1 Hz, 4H), 2.36(m, J 6.7 Hz, 1H), 2.01 (d, J 11.9 Hz, 2H), 1.88 (s, 6H), 1.74 (q d,J 3.8 Hz, 2H), 1.34 (t, J 7.5 Hz, 3H), 0.87 (s, 9H), 0.05 (s, 6H). 13CNMR decoupled (CDCl3, 150 MHz) d: 180.66, 157.00, 156.00, 147.93,137.57, 137.19, 128.22, 126.69, 125.83, 125.52, 123.17, 120.20, 115.95,115.17, 111.59, 105.94, 67.32, 62.00, 61.52, 52.19, 49.98, 47.91, 37.63,29.48, 28.95, 25.77, 23.10, 18.25, 14.41, 5.53. MS: m/z [MH]calculated for C38H53N4O3Si, 641.3887; found, 641.34.
 

Historical Records