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Chemical Structure| 148747-59-5 Chemical Structure| 148747-59-5

Structure of 148747-59-5

Chemical Structure| 148747-59-5

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Product Details of [ 148747-59-5 ]

CAS No. :148747-59-5
Formula : C20H17N3O5
M.W : 379.37
SMILES Code : O=C(O)CN(C(C1=CC=CC=C1)=NC=C2NC(OCC3=CC=CC=C3)=O)C2=O

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Application In Synthesis of [ 148747-59-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 148747-59-5 ]

[ 148747-59-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 23357-46-2 ]
  • [ 148747-59-5 ]
  • [ 1033000-39-3 ]
YieldReaction ConditionsOperation in experiment
75% To a solution of the acid A (Veale, C. A. et. al. J. Med. Chem. 1995,38, 98-108) (379 mg, 1 mmol), 1-hydroxybenzotriazole hydrate (203 mg, 1.5 mmol), and triethylamine (202 mg, 2 mmol) in DMF (5 mL) was added EDC (356 mg, 1.2 mmol), and the solution was stirred for 0.5 h. (R)-(1, 2,3,4-Tetrahydro-naphthalen-l-yl)amine (147 mg, 1 mmol) was added, and the solution was stirred for 16 h. Then the solution was diluted with H2O and extracted with ethyl acetate, washed with a saturated aqueous solution of ammonium chloride (2 x 25 mL). The solution was dried and the solvent removed. The resulting oil crystallized upon standing and was collected and dried to give the titled amide B (383 mg, 75%) as a white solid: 1H NMR (400 MHz, CDCl3): δ 8.75(1H, s), 7.62 (2H, m), 7.51 (4H, m), 7.37 (5H, m), 7.16 (4H, m), 6.08 (IH, d), 5.22 (2H, s), 5.20 (IH, m), 4.56 (2H, s), 2.74 (2H, t), 1.78 (4H, m); MS: 509 (M + H+).
 

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