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Chemical Structure| 14902-36-4 Chemical Structure| 14902-36-4

Structure of 14902-36-4

Chemical Structure| 14902-36-4

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Product Details of [ 14902-36-4 ]

CAS No. :14902-36-4
Formula : C10H14O
M.W : 150.22
SMILES Code : OCCCC1=CC=CC=C1C
MDL No. :MFCD09028767

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Application In Synthesis of [ 14902-36-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14902-36-4 ]

[ 14902-36-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 939-57-1 ]
  • [ 14902-36-4 ]
YieldReaction ConditionsOperation in experiment
Synthesis of 1-(2-fluoro-ethyl)-3-(5-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea The desired starting 3-o-tolylpropan-1-ol was prepared from the commercially available 3-o-tolyl-acrylic acid using the protocol described in the scheme above. The title urea was thus obtained from this alcohol according to general procedure H. The intermediates 3-o-tolylpropan-1-ol, 4-o-tolyl-butyronitrile, 5-methyl-3,4-dihydro-2H-naphthalen-1-one and 5-methyl-1,2,3,4-tetrahydro-naphthalen-1-ylamine were separated and characterized.3-o-Tolyl-propan-1-olxxxix: 3-o-Tolyl-acrylic acid (10.00 g, 62.00 mmol) in THF was mixed with Rh/Al2O3 (800 mg) and hydrogenated at 50 psi for 6 hours. The resulting mixture was filtered through a pad of celite and the filtrate was concentrated. The residue was dissolved in THF and cooled to 0 C. LAH (62.00 mL, 1.0 M in THF, 62.00 mmol) was added and the reaction mixture was stirred for 14 hours. The resulting mixture was quenched with NaOH and extracted with Et2O (3×250 mL). The combined organic extracts were washed with H2O (3×150 mL), brine (1×150 mL), dried over MgSO4 and concentrated to give the title alcohol.
 

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