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[ CAS No. 150319-83-8 ] {[proInfo.proName]}

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Chemical Structure| 150319-83-8
Chemical Structure| 150319-83-8
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Product Details of [ 150319-83-8 ]

CAS No. :150319-83-8 MDL No. :MFCD11501071
Formula : C9H12ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :OOGVJPZOIXNNHQ-UHFFFAOYSA-N
M.W : 201.65 Pubchem ID :44119610
Synonyms :

Safety of [ 150319-83-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 150319-83-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 150319-83-8 ]
  • Downstream synthetic route of [ 150319-83-8 ]

[ 150319-83-8 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 14338-36-4 ]
  • [ 150319-83-8 ]
YieldReaction ConditionsOperation in experiment
96.8% With thionyl chloride In methanol A.
3-Amino phenylacetic acid methylester hydrochloride
A suspension of 3-amino phenylacetic acid (5.0 g, 33 mmol) in methanol (50 ml) at 0° C. under argon was slowly treated with thionyl chloride (19.4 g, 165 mmol).
After completion of addition, the reaction mixture was allowed to warm up to room temperature and stirred for 16 hours.
The solvent was evaporated and the residue was triturated with ethyl ether to give 3-amino phenylacetic acid methylester hydrochloride (5.3 g, 96.8percent) as a colorless solid. 1 H NMR (CDCl3) δ 10.6 (s, 2 H), 7.42 (m, 4 H), 3.68 (s, 3 H).
3.66 (s,2 H); 13 C NMR (CDCl3) 172.5, 137.3, 133.1, 131.2, 130.8, 125.9, 123.7, 53.5, 41.5.
Reference: [1] Patent: US5276168, 1994, A,
  • 2
  • [ 67-56-1 ]
  • [ 14338-36-4 ]
  • [ 150319-83-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 19, p. 4189 - 4206
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 25, p. 6010 - 6023
[3] Patent: WO2005/14552, 2005, A1, . Location in patent: Page/Page column 62
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