Alternatived Products of [ 150560-61-5 ]
Product Details of [ 150560-61-5 ]
CAS No. : | 150560-61-5 |
MDL No. : | MFCD11111593 |
Formula : |
C10H11NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | PFZOPWMHTMNDMV-UHFFFAOYSA-N |
M.W : |
161.20
|
Pubchem ID : | 10154189 |
Synonyms : |
|
Safety of [ 150560-61-5 ]
Application In Synthesis of [ 150560-61-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 150560-61-5 ]
- 1
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[ 64483-69-8 ]
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[ 150560-61-5 ]
Yield | Reaction Conditions | Operation in experiment |
71% |
In triethylsilane; trifluoroacetic acid; |
5-Ethyl-2-oxindole To <strong>[64483-69-8]5-Acetyl-2-oxindole</strong> (2 g) in 15 mL of trifluoroacetic acid in an ice bath was slowly added 1.8 g of triethylsilane; the reaction was then stirred at room temperature for 5 hours. One mL of triethylsilane was added and the stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid. |
71% |
In triethylsilane; trifluoroacetic acid; |
5-Ethyl-2-oxindole To <strong>[64483-69-8]5-Acetyl-2-oxindole</strong> (2 g) in 15 mL of trifluoroacetic acid in an ice bath was slowly added 1.8 g of triethylsilane; the reaction was then stirred at room temperature for 5 hours. One mL of triethylsilane was added and the stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid. |
71% |
With triethylsilane; trifluoroacetic acid; at 0 - 20℃; for 5h; |
5-Ethyl-2-oxindole To <strong>[64483-69-8]5-Acetyl-2-oxindole</strong> (2 g) in 15 ML of trifluoroacetic acid in an ice bath was slowly added 1.8 g of triethylsilane; the reaction was then stirred at room temperature for 5 hours.. One ML of triethylsilane was added and the stirring continued overnight.. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid. |
71% |
With triethylsilane; trifluoroacetic acid; at 20℃; for 5h; |
5-Ethyl-2-oxindole To <strong>[64483-69-8]5-Acetyl-2-oxindole</strong> (2 g) in 15 mL of trifluoroacetic acid in an ice bath was slowly added 1.8 g of triethylsilane; the reaction was then stirred at room temperature for 5 hours. One mL of triethylsilane was added and the stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid. |
|
With hydrogen; acetic acid;palladium; |
The <strong>[64483-69-8]5-acetyloxindole</strong> (54 g, 308 mmol), acetic acid (400 ml) and palladium on carbon (10%, 5 g) are combined and treated with hydrogen for 14 hours at 55 psi. The catalyst is removed by filtering through a bed of Celite, the filtrate is concentrated under reduced pressure and the residue is treated with ether to give 5-ethyloxindole |
Reference:
[1]Patent: US2003/69421,2003,A1
[2]Patent: US6486185,2002,B1
[3]Patent: US6350754,2002,B2 .Location in patent: Page column 24
[4]Patent: US6878733,2005,B1 .Location in patent: Page/Page column 173; 222
[5]Patent: US6291523,2001,B1