[ CAS No. 1513-60-6 ] {[proInfo.proName]}

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Quality Control of [ 1513-60-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1513-60-6 ]

SDS Specification

Alternatived Products of [ 1513-60-6 ]

Product Details of [ 1513-60-6 ]

CAS No. :	1513-60-6	MDL No. :	MFCD00041517
Formula :	C₇H₆F₆O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	236.11	Pubchem ID :	-
Synonyms :

Safety of [ 1513-60-6 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P301+P312-P302+P352-P303+P361+P353-P304+P340-P312-P322-P330-P363-P370+P378-P403+P235-P501	UN#:	1993
Hazard Statements:	H225-H302-H312-H332	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 1513-60-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1513-60-6 ]

[ 1513-60-6 ] Synthesis Path-Downstream 1~50

1
[ 1513-60-6 ]
[ 78185-92-9 ]

Yield	Reaction Conditions	Operation in experiment
86%	With ammonia In diethyl ether at 195 - 293℃;
85%	With ammonia In diethyl ether 1.) -80 deg C, 40 min, 2.) RT, 3 h;
	With ammonia

Reference： [1]Arai, Toru; Imachi, Takashi; Kato, Tamaki; Ogawa, H. Iyehara; Fujimoto, Tsutomu; Nishino, Norikazu [Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 5, p. 1383 - 1389]
[2]Vine, William H.; Hsieh, Kun-hwa; Marshall, Garland R. [Journal of Medicinal Chemistry, 1981, vol. 24, # 9, p. 1043 - 1047]
[3]Knunyants,I.L.; Cheburkov,Yu.A. [Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1960, p. 2002 - 2006][Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1960, # 12, p. 2162 - 2167]

2
[ 151-56-4 ]
[ 1513-60-6 ]
[ 97800-14-1 ]

Yield	Reaction Conditions	Operation in experiment
92%	In diethyl ether at 0℃; for 0.5h;

Reference： [1]Solodin, I. V.; Eremeev, A. V.; Liepin'sh, E. E.; Kostyanovskii, R. G. [Chemistry of Heterocyclic Compounds, 1985, vol. 21, # 4, p. 420 - 423][Khimiya Geterotsiklicheskikh Soedinenii, 1985, vol. 21, # 4, p. 505 - 508]

3
[ 1513-60-6 ]
[ 205537-16-2 ]
[ 97800-15-2 ]

Yield	Reaction Conditions	Operation in experiment
91%	In diethyl ether at 0℃; for 0.5h;

4
[ 110-89-4 ]
[ 1513-60-6 ]
[ 1763-89-9 ]

Yield	Reaction Conditions	Operation in experiment
74%	In diethyl ether for 2h; Ambient temperature;

Reference： [1]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]

5
[ 1513-60-6 ]
[ 917-54-4 ]
[ 143063-59-6 ]

Yield	Reaction Conditions	Operation in experiment
54%	In tetrahydrofuran at -78℃; for 0.5h;

Reference： [1]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]

6
[ 1513-60-6 ]
[ 77600-82-9 ]
[ 121618-39-1 ]

Yield	Reaction Conditions	Operation in experiment
14%	With triethylamine In diethyl ether for 48h; Ambient temperature;

Reference： [1]Mack, Helmut; Hanack, Michael [Liebigs Annalen der Chemie, 1989, p. 833 - 846]

7
[ 1513-60-6 ]
[ 58064-40-7 ]

Yield	Reaction Conditions	Operation in experiment
77%	With triethoxyaluminium hydride In diethyl ether at -78℃; other nucleophiles;
77%	With lithium triethoxyaluminum hydride In diethyl ether at -78℃;

Reference： [1]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]
[2]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]

8
[ 1513-60-6 ]
[ 17327-34-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen
	With hydrogen

Reference： [1]Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al. [Journal of Medicinal Chemistry, 1994, vol. 37, # 9, p. 1282 - 1297]
[2]Puy, Michael Van Der; Poss, Andrew J.; Persichini, Phillip J.; Ellis, Lois A. S. [Journal of Fluorine Chemistry, 1994, vol. 67, # 3, p. 215 - 224]

9
[ 1513-60-6 ]
[ 92629-48-6 ]

Yield	Reaction Conditions	Operation in experiment
72%	With hydroxylamine In ethanol at -20℃; for 1h;
Ca. 11 g	With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine In ethanol at -20 - 20℃;

Reference： [1]Eremeev, A. V.; Solodin, I. V.; Leipin'sh, E. E.; Kostyanovskii, R. G. [Chemistry of Heterocyclic Compounds, 1984, vol. 20, # 7, p. 744 - 748][Khimiya Geterotsiklicheskikh Soedinenii, 1984, vol. 20, # 7, p. 917 - 927]
[2]Benhaim, Cyril; Bouchard, Luc; Pelletier, Guillaume; Sellstedt, John; Kristofova, Livia; Daigneault, Sylvain [Organic Letters, 2010, vol. 12, # 9, p. 2008 - 2011]

10
[ 1513-60-6 ]
[ 108-98-5 ]
[ 143063-58-5 ]

Yield	Reaction Conditions	Operation in experiment
67%	With sodium hydride In tetrahydrofuran; paraffin at 10℃; for 0.5h;

Reference： [1]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]

11
[ 1513-60-6 ]
[ 57-14-7 ]
[ 92629-44-2 ]

Yield	Reaction Conditions	Operation in experiment
85%	In diethyl ether at -20℃; for 0.5h;

12
[ 867-13-0 ]
[ 684-16-2 ]
[ 1513-60-6 ]

Yield	Reaction Conditions	Operation in experiment
56%	With sodium hydride In dimethyl sulfoxide 1) 50 deg C, 12 h, 2) 110 deg C, 2 h;

Reference： [1]Abele, Herbert; Haas, Alois; Lieb, Max [Chemische Berichte, 1986, vol. 119, # 111, p. 3502 - 3506]

13
[ 684-16-2 ]
[ 1099-45-2 ]
[ 1513-60-6 ]

Yield	Reaction Conditions	Operation in experiment
84%	In diethyl ether at -78.1 - 19.9℃;
67%	In diethyl ether 1.) -80 deg C, 1.5 h, 2.) RT, 5 h;
	In toluene

Reference： [1]Arai, Toru; Imachi, Takashi; Kato, Tamaki; Ogawa, H. Iyehara; Fujimoto, Tsutomu; Nishino, Norikazu [Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 5, p. 1383 - 1389]
[2]Vine, William H.; Hsieh, Kun-hwa; Marshall, Garland R. [Journal of Medicinal Chemistry, 1981, vol. 24, # 9, p. 1043 - 1047]
[3]Huff, Roger K.; Savins, Eric G. [Journal of the Chemical Society. Chemical communications, 1980, # 15, p. 742 - 743]

14
[ 1513-60-6 ]
[ 105-53-3 ]
[ 143063-57-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With sodium hydride In tetrahydrofuran; paraffin at 10℃; for 0.5h;

Reference： [1]Martin, Valerie; Molines, Huguette; Wakselman, Claude [Journal of Organic Chemistry, 1992, vol. 57, # 20, p. 5530 - 5532]

15
[ 83740-44-7 ]
[ 1513-60-6 ]

Yield	Reaction Conditions	Operation in experiment
50%	With boron trifluoride diethyl etherate at 20℃; for 48h;

Reference： [1]Zaitseva, G. S.; Livantsova, L. I.; Orlova, N. A.; Baukov, Yu. I.; Lutsenko, I. F. [Journal of general chemistry of the USSR, 1982, vol. 52, p. 1847 - 1854][Zhurnal Obshchei Khimii, 1982, vol. 52, # 9, p. 2076 - 2084]

16
[ 684-93-5 ]
[ 1513-60-6 ]
[ 390388-85-9 ]

Yield	Reaction Conditions	Operation in experiment
99%	Stage #1: 1-methyl-1-nitrosourea With potassium hydroxide In diethyl ether at 0℃; Stage #2: ethyl 4,4,4-trifluoro-3-(trifluoromethyl)crotonate In diethyl ether at 20℃; for 1h;

17
[ 1002724-25-5 ]
[ 1513-60-6 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine at 20 - 60℃; for 2h;	2 17.6 g (0.043 mol) of ethyl 4,4,4-trifluoro-3-trifluoroacetyl-butanoate with a purity of 85.6 % were mixed with 4.10 g (0.041 mol) of triethylamine in a glass flask equipped with a condenser cooled down to 50C. The reaction was started at room temperature, but due to the exothermic nature of the reaction, the temperature increased to 6O0C. After 2 h, the reaction medium was washed first with a NH4Cl saturated water solution (2 x 40 ml) and then with 40 ml of water. The organic phase was separated from the aqueous phase by decantation and dried over MgSO4. Analysis by gas chromatography showed a complete conversion of ethyl 4,4,4-trifluoro-3-trifluoroacetyl-butanoate, with a selectivity of 99 % into ethyl 4,4,4-trifluoro-3-trifluoromethyl crotonate (ETFMC). ETFMC was then distilled under vacuum.

Reference： [1]Current Patent Assignee: SOLVAY - WO2008/9674, 2008, A1 Location in patent: Page/Page column 6-7

18
[ 1513-60-6 ]
[ 390388-89-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C

Reference： [1]Miyazawa, Kazutoshi; De Meijere, Armin [Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 2001, vol. 364, p. 529 - 546]
[2]Miyazawa, Kazutoshi; De Meijere, Armin [Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 2001, vol. 364, p. 529 - 546]

19
[ 1513-60-6 ]
[ 390388-88-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C
	Multi-step reaction with 3 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C

20
[ 1513-60-6 ]
[ 390388-87-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating
	Multi-step reaction with 3 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating

21
[ 1513-60-6 ]
(R)-(-)-2,2-bis(trifluoromethyl)cyclopropane-1-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C

22
[ 1513-60-6 ]
[ 390388-86-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating
	Multi-step reaction with 2 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis

23
[ 1513-60-6 ]
(R)-2,2-Bis-trifluoromethyl-cyclopropanecarboxylic acid (S)-1-phenyl-ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP

24
[ 1513-60-6 ]
(S)-2,2-Bis-trifluoromethyl-cyclopropanecarboxylic acid (S)-1-phenyl-ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP

25
[ 1513-60-6 ]
R-(-)-4-(5-octylpyrimid-2-yl)phenyl 2,2-bis(trifluoromethyl)cyclpropane-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C 6.1: DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C
	Multi-step reaction with 6 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C 6.1: DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

26
[ 1513-60-6 ]
1-[2,2-bis(trifluoromethyl)cycloprop-1-ylmethyleneoxy]-4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C 5.1: 21 percent / K₂CO₃ / ethanol / 7 h / Heating
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C 5.1: 21 percent / K₂CO₃ / ethanol / 7 h / Heating

27
[ 1513-60-6 ]
(R)-(-)-4-pentyl-1,1'-biphenyl-4'-yl 4-[2,2-bis(trifluoromethyl)cyclopropanoyloxy]benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C 6.1: DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C
	Multi-step reaction with 6 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: DCC; DMAP 5.1: aq. HBr / acetic acid / 20 °C 6.1: DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

28
[ 1513-60-6 ]
4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]phenyl 2,2-bis(trifluoromethyl)cyclopropane-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: 69 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: 69 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

29
[ 1513-60-6 ]
2,3-difluoro-1-[2,2-bis(trifluoromethyl)cycloprop-1-ylmethyleneoxy]-4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C 5.1: 52 percent / K₂CO₃ / ethanol / 7 h / Heating
	Multi-step reaction with 5 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 69 percent / LiAlH₄ / diethyl ether / 2.5 h / 20 °C 4.1: 94 percent / Br₂; PPh₃; pyridine / CH₂Cl₂ / 12 h / 20 °C 5.1: 52 percent / K₂CO₃ / ethanol / 7 h / Heating

30
[ 1513-60-6 ]
2,3-difluoro-4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]phenyl 2,2-bis(trifluoromethyl)cyclopropane-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 99 percent / CCl₄ / 7 h / UV-irradiation; heating 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: 79 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C
	Multi-step reaction with 4 steps 1.1: aq. KOH / diethyl ether / 0 °C 1.2: 99 percent / diethyl ether / 1 h / 20 °C 2.1: 180 °C / Pyrolysis 3.1: 86 percent / NaOH / ethanol; H₂O / 3 h / Heating 4.1: 79 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

31
[ 1513-60-6 ]
[ 16063-80-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86 percent / NH₃ / diethyl ether / 195 - 293 °C 2: 91 percent / 6M aq. HCl / 7 h / Heating
	Multi-step reaction with 2 steps 1: 85 percent / liguid NH₃ / diethyl ether / 1.) -80 deg C, 40 min, 2.) RT, 3 h 2: 80 percent / 6N HCl / 7 h / 90 °C
	Multi-step reaction with 2 steps 1: NH₃ 2: aq. HCl

32
[ 1513-60-6 ]
[ 107496-46-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 86 percent / NH₃ / diethyl ether / 195 - 293 °C 2: 91 percent / 6M aq. HCl / 7 h / Heating 3: 72 percent / Et₃N / dioxane; H₂O / Ambient temperature

Reference： [1]Arai, Toru; Imachi, Takashi; Kato, Tamaki; Ogawa, H. Iyehara; Fujimoto, Tsutomu; Nishino, Norikazu [Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 5, p. 1383 - 1389]

33
[ 1513-60-6 ]
[ 17327-35-4 ]