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Chemical Structure| 151330-02-8

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Product Details of [ 151330-02-8 ]

CAS No. :151330-02-8
Formula : C11H11NO3
M.W : 205.21
SMILES Code : O=C(C1CCC2=C(C=NC=C2)C1=O)OC
MDL No. :MFCD25959313

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 151330-02-8 ]

[ 151330-02-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33402-75-4 ]
  • [ 292638-85-8 ]
  • [ 151330-02-8 ]
YieldReaction ConditionsOperation in experiment
In a nitrogen atmosphere, 9.8 mL of 1.50 M n-butyllithium/hexane solution was dropwise added to tetrahydrofuran (35 mL) solution of 2.1 mL of diisopropylamine at -78C, and stirred at -78C for 30 minutes. Tetrahydrofuran (10 mL) solution of 1.63 g of the compound obtained in the above 1 was dropwise added to the reaction liquid, and stirred at -78C for 30 minutes. Next, tetrahydrofuran (5 mL) solution of 1.7 mL of methyl acrylate was dropwise added to the reaction liquid, and stirred at -78C for 1.5 hours. Further, aqueous 10 % acetic acid solution was added to the reaction liquid, and heated up to room temperature, and then the solvent was evaporated off under reduced pressure. Aqueous saturated sodium hydrogencarbonate solution was added to the residue, and extracted with chloroform. The chloroform layer was washed with saturated saline water, and dried with anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was separated and purified through silica gel column chromatography (chloroform/methanol = 99/1) to obtain 1.60 g of the entitled compound as a yellow oily substance.
 

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