There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 151412-12-3 | MDL No. : | MFCD00042470 |
Formula : | C8H8BrF | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 203.05 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P303+P361+P353-P210-P501-P260-P301+P330+P331-P305+P351+P338 | UN#: | 1760 |
Hazard Statements: | H302-H314 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Preparation 98: 1-Benzyl-4-(2-fluoro-3-methyl-benzyl)-piperidine-4-carboxylic acid ethyl esterTo a solution of "l-benzyl-piperdine-4-carboxylic acid ethyl ester (15g, 60.64mmol) in THF (5OmL) at -780C was added a 1.8M solution of LDA in THF (37mL, 66.60mmol) over 10 minutes. The resulting mixture was stirred at -780C for 1 hour and then a solution of 2-fluoro-3-methylbenzyl bromide (13.5g, 66.48mmol) in THF (2OmL) was added. The resulting mixture was stirred at - 780C for 30 minutes then at room temperature for 18 hours. The reaction was poured into water (5OmL), and the mixture extracted with EtOAc (2x50mL). The combined organic extracts were dried over Na2SO4 and evaporated under reduced pressure to afford the title compound, 22.1 g. LRMS APCI m/z 370 [M+H]+ |