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Chemical Structure| 152241-38-8 Chemical Structure| 152241-38-8

Structure of 152241-38-8

Chemical Structure| 152241-38-8

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Product Details of [ 152241-38-8 ]

CAS No. :152241-38-8
Formula : C13H21N3O2
M.W : 251.33
SMILES Code : O=C(N1CCC(C2=CNC=N2)CC1)OC(C)(C)C
MDL No. :MFCD00924431

Safety of [ 152241-38-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 152241-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 152241-38-8 ]

[ 152241-38-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3473-63-0 ]
  • [ 301221-79-4 ]
  • [ 152241-38-8 ]
YieldReaction ConditionsOperation in experiment
With ammonia; at 40℃; under 10032.9 Torr; for 20h; The bromomethylketone prepared as described in Steps A-C of the synthesis of Intermediate 10 (2.02 g, 6.60 mmol) was combined with FORMAMIDINE acetate (1.37 g, 13.2 mmol) in-130 mL of NH3 (1) and heated in an autoclave at 40 °C and 194 psi for 20 h. The NH3 was allowed to evaporate, the residue was dissolved in DCM and filtered. The filtrate was concentrated. Purification by flash chromatography (silica, 10percent of 1: 9 NH4OH/METHANOL in DCM) afforded 649 mg of the imidazole product. APOS;H NMR (400 MHz, CD30D) : 8 7.56 (d, J = 1.2 Hz, 1H), 6.74 (d, J = 1. 2 Hz, 1H), 4.13 (br s, 2H), 2.82 (m, 2H), 2.74 (m, 1H), 1.97 (m, 2H), 1.54 (m, 2H), 1.44 (s, 9H).
 

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