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Chemical Structure| 152351-91-2 Chemical Structure| 152351-91-2

Structure of 152351-91-2

Chemical Structure| 152351-91-2

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Product Details of [ 152351-91-2 ]

CAS No. :152351-91-2
Formula : C12H20BrNOSi
M.W : 302.28
SMILES Code : C[Si](OCC1=CN=CC(Br)=C1)(C(C)(C)C)C
MDL No. :MFCD11977409

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Application In Synthesis of [ 152351-91-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 152351-91-2 ]

[ 152351-91-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 116332-54-8 ]
  • [ 152351-91-2 ]
  • [ 1033125-26-6 ]
YieldReaction ConditionsOperation in experiment
69% To a solution of 3-bromo-5-(tert-butyl-dimethyl-silanyloxymethyl)-pyridine (IG) (1.0 g, 3.3mmol) in 15 mL of ether at - 75 0C, is added n-butyl lithium ( 1.4 mL, 3.6 mmol, <n="28"/>2.5M in hexane) drop wise. After being stirred at - 75 0C for 30 minuets, a solution of 4- fluoro-N-methoxy-N-methyl-benzamide (0.69 g, 3.8 mmol) in 5 mL of ether is added to the reaction solution drop wise. After being stirred at -75 0C for 1 hour, the reaction solution is warmed to room temperature in 1 hour, and quenched by addition of 10 mL of water. The mixture is extracted with 2 x 15 mL of EtOAc. After concentration, the crude product is purified by chromatography (heptane 90%, EtOAc 10%) to give [5-(tert-butyl- dimethyl-silanyloxymethyl)-pyridin-3-yl]-(4-fluoro-phenyl)-methanone (IH) (0.79 g, Yield 69 %) as colorless liquid. MS (ESI) m/e 346 (M + H+).
 

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