Alternatived Products of [ 152567-82-3 ]
Product Details of [ 152567-82-3 ]
| CAS No. : | 152567-82-3 |
MDL No. : | MFCD01929328 |
| Formula : |
C13H10O3S
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
246.28
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 152567-82-3 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 152567-82-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 152567-82-3 ]
- 1
-
[ 554-14-3 ]
-
[ 85-44-9 ]
-
[ 152567-82-3 ]
| Yield | Reaction Conditions | Operation in experiment |
| 96% |
With aluminium trichloride In 1,2-dichloro-ethane at 40℃; for 2h; |
|
| 89% |
With aluminium trichloride In nitrobenzene at 40 - 45℃; for 1h; |
|
| 78% |
With aluminium trichloride In dichloromethane Ambient temperature; |
|
|
With carbon disulfide; aluminium trichloride |
|
|
With aluminium trichloride; nitrobenzene |
|
Reference：
[1]Kohara, Toshiyuki; Tanaka, Hiroshi; Kimura, Koreichi; Fujimoto, Tetsuya; Yamamoto, Iwao; Arita, Masafumi
[Synthesis, 2002, # 3, p. 355 - 360]
[2]Lahiri, Sikha; Sen
[Journal of the Indian Chemical Society, 1999, vol. 76, # 4, p. 209 - 212]
[3]Yamaguchi; Kamei; Koga; Akima; Kuroki; Ohi
[Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4052 - 4060]
[4]Buu-Hoi et al.
[Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1083,1103]
[5]Weinmayr
[Journal of the American Chemical Society, 1952, vol. 74, p. 4353,4356]
- 2
-
[ 67-56-1 ]
-
[ 152567-82-3 ]
-
2-(5-methyl-thiophene-2-carbonyl)-benzoic acid methyl ester
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
With hydrogenchloride |
|
- 3
-
[ 64-17-5 ]
-
[ 152567-82-3 ]
-
2-(5-methyl-thiophene-2-carbonyl)-benzoic acid ethyl ester
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
With hydrogenchloride |
|
- 4
-
[ 152567-82-3 ]
-
[ 73338-82-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With aluminium trichloride; nitrobenzene at 135℃; |
|
|
With phosphorus pentachloride; tin(IV) chloride |
|
- 5
-
[ 152567-82-3 ]
-
[ 137382-47-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 88% |
With hydrazine hydrate In ethanol for 5h; Heating; |
|
|
With hydrazine hydrate |
|
|
With hydrazine hydrate In ethanol for 8h; Reflux; |
|
Reference：
[1]Yamaguchi; Kamei; Koga; Akima; Kuroki; Ohi
[Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4052 - 4060]
[2]Buu-Hoi et al.
[Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1083,1103]
[3]Location in patent: experimental part
Lim, Chae Jo; Lee, Ka Eun; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang
[Bulletin of the Korean Chemical Society, 2012, vol. 33, # 7, p. 2389 - 2392]
- 6
-
[ 152567-82-3 ]
-
[ 152567-96-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 52% |
With pyridine; potassium permanganate In water Heating; |
|
- 7
-
[ 152567-82-3 ]
-
[ 238756-53-1 ]
| Yield | Reaction Conditions | Operation in experiment |
| 74% |
With ammonium hydroxide; copper(I) sulfate; zinc |
|
| 67% |
With ammonium hydroxide; copper(II) sulfate; zinc at 70℃; for 6h; |
|
Reference：
[1]Lahiri, Sikha; Sen
[Journal of the Indian Chemical Society, 1999, vol. 76, # 4, p. 209 - 212]
[2]Kohara, Toshiyuki; Tanaka, Hiroshi; Kimura, Koreichi; Fujimoto, Tetsuya; Yamamoto, Iwao; Arita, Masafumi
[Synthesis, 2002, # 3, p. 355 - 360]
- 8
-
[ 85-44-9 ]
-
[ 152567-82-3 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With diethyl ether; methoxybenzene |
|
- 9
-
[ 152567-82-3 ]
-
[ 80517-58-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C |
|
- 10
-
[ 152567-82-3 ]
-
[ 71576-93-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C |
|
- 11
-
[ 152567-82-3 ]
-
[ 439262-80-3 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C |
|
- 12
-
[ 152567-82-3 ]
-
[ 439262-82-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 75 percent / aq. HBr / 2 h / Heating |
|
- 13
-
[ 152567-82-3 ]
-
[2-(5-methyl-thiophen-2-ylmethyl)-phenyl]-acetonitrile
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 75 percent / aq. HBr / 2 h / Heating
5: dimethylformamide; H2O / 3 h / 20 °C |
|
- 14
-
[ 152567-82-3 ]
-
2-(5-methyl-2-thenyl)benzoic acid methyl ester
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating |
|
- 15
-
[ 152567-82-3 ]
-
2-(5-methyl-thiophen-2-ylmethyl)-benzoyl azide
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C |
|
- 16
-
[ 152567-82-3 ]
-
[ 439262-84-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 75 percent / aq. HBr / 2 h / Heating
5: dimethylformamide; H2O / 3 h / 20 °C
6: 7.84 g / aq. HCl / acetic acid / 4 h / 95 °C |
|
- 17
-
[ 152567-82-3 ]
-
[ 439262-86-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 75 percent / aq. HBr / 2 h / Heating
5: dimethylformamide; H2O / 3 h / 20 °C
6: 7.84 g / aq. HCl / acetic acid / 4 h / 95 °C
7: 65 percent / P2O5 / toluene / 13 h / 90 °C |
|
- 18
-
[ 152567-82-3 ]
-
10-chloro-2-methyl-3-thia-9-aza-benzo[<i>f</i>]azulen-4-one
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating |
|
- 19
-
[ 152567-82-3 ]
-
[ 439262-91-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C |
|
- 20
-
[ 152567-82-3 ]
-
C16H16O4S
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C |
|
- 21
-
[ 152567-82-3 ]
-
2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[5,6]cyclohepta[1,2-b]thiophene
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 8 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: 78 percent / SOCl2 / 6 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 75 percent / aq. HBr / 2 h / Heating
5: dimethylformamide; H2O / 3 h / 20 °C
6: 7.84 g / aq. HCl / acetic acid / 4 h / 95 °C
7: 65 percent / P2O5 / toluene / 13 h / 90 °C
8: 51 percent / TiCl4 / benzene / 1 h / 55 °C |
|
- 22
-
[ 152567-82-3 ]
-
[ 439262-68-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 8 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating |
|
- 23
-
[ 152567-82-3 ]
-
[ 439262-70-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 9 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 79 percent / NaBH4 / tetrahydrofuran / 1 h / 20 °C |
|
- 24
-
[ 152567-82-3 ]
-
2-methyl-10-methylene-4-(4-methylpiperazin-1-yl)thieno[3,2-c][1]benzazepine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 10 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 170 mg / tetrahydrofuran; diethyl ether / 1.5 h / 5 °C
10: 94 mg / aq. HCl / dioxane / 18 h / Heating |
|
- 25
-
[ 152567-82-3 ]
-
2-methyl-4-(4-methylpiperazin-1-yl)-10-methoxythieno[3,2-c][1]benzazepine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 10 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 79 percent / NaBH4 / tetrahydrofuran / 1 h / 20 °C
10: 68 percent / H2SO4 / 2 h / Heating |
|
- 26
-
[ 152567-82-3 ]
-
10-hydroxy-2,10-dimethyl-4-(4-methylpiperazin-1-yl)thieno[3,2-c][1]benzazepine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 9 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 170 mg / tetrahydrofuran; diethyl ether / 1.5 h / 5 °C |
|
- 27
-
[ 152567-82-3 ]
-
2-methyl-10-(1-methylethylidene)-4-(4-methylpiperazin-1-yl)thieno[3,2-c][1]benzazepine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 10 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 170 mg / tetrahydrofuran; diethyl ether / 2 h / 5 °C
10: 460 mg / aq. HCl / dioxane / 4 h / Heating |
|
- 28
-
[ 152567-82-3 ]
-
4-isopropyl-2-methyl-10-(4-methyl-piperazin-1-yl)-4<i>H</i>-3-thia-9-aza-benzo[<i>f</i>]azulen-4-ol
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 9 steps
1: 67 percent / Zn; CuSO4; aq. NH3 / 6 h / 70 °C
2: Et3N / acetone / 1 h / -60 °C
3: aq. NaN3 / acetone / 2 h / 0 °C
4: 1,2-dichloro-benzene / 1 h / 60 °C
5: 2.2 g / AlCl3 / 1,2-dichloro-benzene / 0.5 h / 100 °C
6: 88 percent / KMnO4 / acetone / 1 h / 20 °C
7: POCl3; N,N-dimethylaniline / 1 h / Heating
8: 460 mg / 2.5 h / Heating
9: 170 mg / tetrahydrofuran; diethyl ether / 2 h / 5 °C |
|
- 29
-
[ 152567-82-3 ]
-
[ 152567-97-0 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 52 percent / KMnO4, pyridine / H2O / Heating
2: 65 percent / N2H4 / ethanol / Heating |
|
- 30
-
[ 152567-82-3 ]
-
[ 152567-98-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 52 percent / KMnO4, pyridine / H2O / Heating
2: 65 percent / N2H4 / ethanol / Heating
3: 65 percent / H(+) |
|
- 31
-
[ 152567-82-3 ]
-
2-(2-Imidazol-1-yl-ethyl)-4-(5-methyl-thiophen-2-yl)-2H-phthalazin-1-one
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 88 percent / 80percent N2H4*H2O / ethanol / 5 h / Heating
2: 67 percent / K2CO3 / dimethylformamide / 5 h / 80 °C |
|
- 32
-
[ 152567-82-3 ]
-
5-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-thiophene-2-carboxylic acid
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: 52 percent / KMnO4, pyridine / H2O / Heating
2: 65 percent / N2H4 / ethanol / Heating
3: 65 percent / H(+)
4: 73 percent / K2CO3 / dimethylformamide / 80 °C
5: 83 percent / aq. NaOH |
|
- 33
-
[ 152567-82-3 ]
-
[ 152567-77-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: 52 percent / KMnO4, pyridine / H2O / Heating
2: 65 percent / N2H4 / ethanol / Heating
3: 65 percent / H(+)
4: 73 percent / K2CO3 / dimethylformamide / 80 °C |
|
- 34
-
[ 152567-82-3 ]
-
[ 1373341-10-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / 8 h / Reflux
2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
3: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 100 °C |
|
- 35
-
[ 152567-82-3 ]
-
[ 1373341-21-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: hydrazine hydrate / ethanol / 8 h / Reflux
2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C |
|
- 36
-
[ 88-65-3 ]
-
[ 152567-82-3 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Stage #1: 2-bromobenzoic-acid With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 5-methyl-2-thiophenyl carboxylic ester In tetrahydrofuran at -78℃; |
|
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
