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[ CAS No. 15298-58-5 ]

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Chemical Structure| 15298-58-5
Chemical Structure| 15298-58-5
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Product Details of [ 15298-58-5 ]

CAS No. :15298-58-5 MDL No. :MFCD05664199
Formula : C9H5Cl2N Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :198.05 g/mol Pubchem ID :640955
Synonyms :

Safety of [ 15298-58-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 15298-58-5 ]

  • Upstream synthesis route of [ 15298-58-5 ]
  • Downstream synthetic route of [ 15298-58-5 ]

[ 15298-58-5 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 56241-09-9 ]
  • [ 15298-58-5 ]
YieldReaction ConditionsOperation in experiment
66% for 4 h; Heating / reflux A solution of 4-chloro-2H-isoquinolin-l-one (Product of Step 2,3. 1 g, 17 mmol) in POC13 (20 mL) was refluxed for 4 h. After cooling and concentration, the residue was extracted with CHC13 (50 ml) and neutralized with IN NaOH. The organic layer was washed with brine, dried over MgS04 and concentrated in vacuo. The crude product was purified by flash column chromatograph (Biotage Flash 40M) eluted with 5percent EtOAc in hexane to give the product (2.3 g, 66percent). 1H NMR (400 MHz, CDC13) b ppm 7.77 (ddd, J=8. 31, 7.09, 1.22 Hz, 1 H), 7.88 (ddd, J=8. 3 1, 7.09, 1.22 Hz, 1 H), 8.23 (d, J=8. 31 Hz, 1 H), 8. 34 (s, 1 H), 8. 36 (d, J=8. 56 Hz, 1 H); MS 198 (M+H) +.
Reference: [1] Patent: WO2005/51410, 2005, A1, . Location in patent: Page/Page column 93
  • 2
  • [ 21201-50-3 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of the American Chemical Society, 1958, vol. 80, p. 3443,3448
  • 3
  • [ 105592-81-2 ]
  • [ 15298-58-5 ]
  • [ 105608-16-0 ]
Reference: [1] Chemical & Pharmaceutical Bulletin, 1985, vol. 33, # 12, p. 5328 - 5331
  • 4
  • [ 99357-98-9 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of the American Chemical Society, 1958, vol. 80, p. 3443,3448
  • 5
  • [ 56241-09-9 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1071
  • 6
  • [ 491-30-5 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1071
  • 7
  • [ 58022-38-1 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1071
  • 8
  • [ 21201-50-3 ]
  • [ 10025-87-3 ]
  • [ 15298-58-5 ]
Reference: [1] Journal of the American Chemical Society, 1958, vol. 80, p. 3443,3448
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