Home Cart 0 Sign in  

[ CAS No. 153034-86-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 153034-86-7
Chemical Structure| 153034-86-7
Structure of 153034-86-7 * Storage: {[proInfo.prStorage]}

Quality Control of [ 153034-86-7 ]

Related Doc. of [ 153034-86-7 ]

SDS
Alternatived Products of [ 153034-86-7 ]
Alternatived Products of [ 153034-86-7 ]

Product Details of [ 153034-86-7 ]

CAS No. :153034-86-7 MDL No. :MFCD01861983
Formula : C5H3ClIN Boiling Point : 255.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :239.44 g/mol Pubchem ID :1516511
Synonyms :

Safety of [ 153034-86-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338-P310 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 153034-86-7 ]

  • Upstream synthesis route of [ 153034-86-7 ]
  • Downstream synthetic route of [ 153034-86-7 ]

[ 153034-86-7 ] Synthesis Path-Upstream   1~32

  • 1
  • [ 153034-86-7 ]
  • [ 31729-70-1 ]
  • [ 3678-62-4 ]
Reference: [1] Synlett, 2015, vol. 26, # 17, p. 2395 - 2398
  • 2
  • [ 78607-36-0 ]
  • [ 153034-86-7 ]
YieldReaction ConditionsOperation in experiment
95% With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3 h; A solution of 2-chloro-3-iodopyridine (12 g, 50 mmol) in 20 ML of THF was slowly added to a cold (-78°C) lithium diisopropylamide solution (prepared by the addition of n- butyllithium 1.6 M (31.25 ML, 50 mmol) in hexanes to a solution of diisopropylamine (7 mL, 50 mmol) in THF (100 mL). After 3h, water (20 mL) was added to the mixture, which was extracted with ether (2 x 100 mL). The organic layers were dried over magnesium sulfate, filtered and concentrated under vacuum (20°C) to afford a brown solid, which was purified by filtration over silica (ethyl acetate/heptane 8/2). Yield: 95percent (11.4 g), pale yellow NEEDLES. IH NMR (CDC13) : 8 8.07 (d, J = 5.3 Hz, 1H), 7.76 (d, J = 1.1 Hz, 1H), 7.59 (dd, J = 5. 0/1. 1 Hz, 1H). 13C NMR (CDC13) : 8 151.7, 149.6, 133. 0,131. 5,106. 6. MS (EI) m/z 240 (M+1).
80% With n-butyllithium; diisopropylamine In tetrahydrofuran at -78 - -15℃; for 1.33333 h; To a THF solution (40 ml) of Diisopropyl amine (4.46 ml, 1.5 eqv) was added BuLi (1.88 M, 1.5 eqv) at -15° C. and the resulting reaction mixture was allowed to stir at same temperature for 20 minutes. It was then cooled to -78° C. and 2-chloro-3-iodopyridine (5 g, 20.92 mmol) in THF (10 ml) was added dropwise at the same temperature and allowed to stir for 1 hr at -78° C. Reaction was quenched with water (10 ml), stirred at ambient temperature for 15 minutes and extracted with ethyl acetate. Organic layer was washed successively with brine and finally dried over sodium sulfate. Evaporation of organic layer under reduced pressure gave the crude product which was immediately used in the next step without any further purification. Yield: 80percent (Crude)
75%
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran at -78 - -5℃; for 2 h;
Stage #2: With water In tetrahydrofuran for 0.25 h;
Preparation of amine unit A4 1. A solution of diisopropylamine (12.7 g) in THF (160 ml) was cooled to -15° C., and n-BuLi (83 ml) was added dropwise over a period of 20 min at -10° C. After stirring for 20 min at -5° C., the reaction mixture was cooled to -78° C., and 2-chloro-3-iodo-pyridine (20 g) dissolved in THF (40 ml) was added dropwise over a period of 20 min. The reaction mixture was stirred for 1 h at -78° C. After addition of water (40 ml), stirring was carried out for 15 min. The organic phase was separated off and dried over Na2SO4. After filtration, the solvent was removed in vacuo and the residue was purified by flash chromatography (silica, 5percent ethyl acetate/n-hexane). Yield: 15 g (75percent)
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1397 - 1401
[2] Patent: WO2004/52880, 2004, A1, . Location in patent: Page 30
[3] Patent: US2009/186899, 2009, A1, . Location in patent: Page/Page column 45-46
[4] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[5] Patent: US2008/249128, 2008, A1, . Location in patent: Page/Page column 46
[6] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[7] Patent: WO2009/90055, 2009, A1, . Location in patent: Page/Page column 133; 134
[8] Patent: US2009/264400, 2009, A1, . Location in patent: Page/Page column 64
  • 3
  • [ 14432-12-3 ]
  • [ 153034-86-7 ]
YieldReaction ConditionsOperation in experiment
63%
Stage #1: With hydrogenchloride In water at 0℃;
Stage #2: With sodium nitrite In water at -10℃; for 0.666667 h;
To a ice-cooled solution of 4-amino-2-chloro-pyridine (8.09g, 63 mmol, 1eq) in water [(150ML)] was added concentrated 98percent HCl whilst maintaining the reaction at [0°C A] solution of sodium nitrite (5.65g, [82MMOL,] 1.3eq) in water [(50ML)] was added slowly [AT-10°C.] The mixture was stirred at-10°C [FOR 40 MIN] and a solution of potassium iodide (12.55g, 75. [6MMOL,] 1.2eq) in water [(50ML)] was added. The resulting mixture was stirred at [0°C] overnight. After treatment with [NAOH] 35percent, and extraction with ethyl acetate, the organic phases were combined and dried over [NA2SO4.] The solvent was removed under reduced pressure and the residue was purified by chromatography on silica gel (eluent : CH2CI2 then [CH2CL2/CH30H] 99/1) to give the title compound as an orange solid (9.5g, 63percent) ;'H NMR (300 MHz, CDCl3) [6] : 7.99 (d, [1H),] 7.68 (s, 1H), 7.52 (d, 1H) ; (GC-MS) m/z: 239.
63%
Stage #1: With hydrogenchloride; sodium nitrite In water at -10℃; for 0.666667 h;
Stage #2: With potassium iodide In water at 0℃;
To a solution of 4-amino-2-chloro-pyridine (8.09g, 63 mmol, [1EQ)] in water [(150ML)] cooled to [0°C] was added concentrated 98percent HCI. A solution of sodium nitrite (5.65g, [82MMOL,] 1.3eq) in water (50mL) was added slowly at-10°C and the mixture was stirred at this temperature for 40 min. A solution of potassium iodide [(12.] 55g, 75. [6MMOL,] 1.2eq) in water (50mL) was added and the resulting mixture was stirred at [0°C] overnight. After treatment with NaOH (35percent) and extraction with ethyl acetate, the organic phases were combined and dried over [NA2SO4.] The solvent was removed under reduced pressure and the residue was purified by chromatography on silica gel (eluent : CH2CI2 then [CH2CI2/CH30H] 99: 1) to give the title compound as an orange solid (9.5g, 63percent) [; 1H] NMR (300 MHz, [CD13)] [8] ppm: 7.99 (1H, d), 7.68 (1H, s), 7.52 (1H, d); (GC-MS) m/z: 239.
34% With copper(l) iodide; tert.-butylnitrite In acetonitrile at 0 - 20℃; for 16 h; General procedure: To a mixture of copper source (1.2 eq., CuBr2 for 4b, CuCl2 for 4c, CuI for 4d)in acetonitrile (0.4M) was slowly added tBuONO (1.5 eq.). The mixture was stirred for15 min and then cooled to 0°C. A solution of 2-chloro-4-aminopyridine 3 (1.0 eq.) inacetonitrile (0.5M) was slowly added. The mixture was stirred for 1h at 0°C and thenallowed to warm to r.t. for 16h. After concentration in vacuo, aq. 15percent ammonia solution (1.3 mL/mmol) was added, and the aqueous layer was extracted withdichloromethane (10 mL/mmol; 3x). The combined organic layers were washed withbrine, dried (Na2SO4), filtered and carefully concentrated under reduced pressure(CAUTION: volatile products) to give the crude 4b-d, which was used in the next stepwithout purification.
Reference: [1] Patent: WO2004/13125, 2004, A1, . Location in patent: Page 18
[2] Patent: WO2004/13135, 2004, A1, . Location in patent: Page 42-43
[3] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[4] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[5] Chem.Abstr., 1956, p. 12045
  • 4
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 78607-36-0 ]
Reference: [1] Tetrahedron Letters, 2004, vol. 45, # 42, p. 7873 - 7877
[2] ChemPhysChem, 2016, vol. 17, # 24, p. 4090 - 4101
  • 5
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
Reference: [1] ChemPhysChem, 2016, vol. 17, # 24, p. 4090 - 4101
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1397 - 1401
[3] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
  • 6
  • [ 65287-34-5 ]
  • [ 153034-86-7 ]
Reference: [1] Nature Chemistry, 2018, vol. 10, # 10, p. 1016 - 1022
  • 7
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 8
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 116195-81-4 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 9
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 1353056-33-3 ]
  • [ 1353056-34-4 ]
  • [ 78607-36-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 10
  • [ 2402-95-1 ]
  • [ 153034-86-7 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 11
  • [ 14432-16-7 ]
  • [ 153034-86-7 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 12
  • [ 153034-86-7 ]
  • [ 700811-29-6 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3454 - 3458
[2] Patent: US2013/165464, 2013, A1, . Location in patent: Paragraph 0887
  • 13
  • [ 153034-86-7 ]
  • [ 73027-79-9 ]
Reference: [1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
  • 14
  • [ 153034-86-7 ]
  • [ 141-52-6 ]
  • [ 52311-50-9 ]
YieldReaction ConditionsOperation in experiment
5 g Reflux 6.01.22.01 2-chloro-4-ethoxy-pyridine 33 ml sodium ethoxide was added to 19.2 g 2-chloro-4-iodopyridine in 150 mL ethanol. The reaction was refluxed overnight. Then water was added and extracted with tert-butyl- methylether. The organic layer was evaporated and the residue cleanded by chromatography on silica gel (petrolether/EtOAC:9/l) to yield 5 g of the desired compound. Rf: 0.3 (petrolether/EtOAC:4/l), (M+H)+: 158
5 g Reflux 6.01.22.01
2-chloro-4-ethoxy-pyridine
33 ml sodium ethoxide was added to 19.2 g 2-chloro-4-iodopyridine in 150 mL ethanol.
The reaction was refluxed overnight.
Then water was added and extracted with tert-butyl-methylether.
The organic layer was evaporated and the residue cleanded by chromatography on silica gel (petrolether/EtOAC:9/1) to yield 5 g of the desired compound.
Rf: 0.3 (petrolether/EtOAC:4/1), (M+H)+: 158
Reference: [1] Patent: WO2013/107761, 2013, A1, . Location in patent: Page/Page column 60; 61
[2] Patent: US2013/184248, 2013, A1, . Location in patent: Paragraph 0318; 0319; 0320
  • 15
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 78607-36-0 ]
Reference: [1] Tetrahedron Letters, 2004, vol. 45, # 42, p. 7873 - 7877
[2] ChemPhysChem, 2016, vol. 17, # 24, p. 4090 - 4101
  • 16
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 17
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 116195-81-4 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 18
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 1353056-33-3 ]
  • [ 1353056-34-4 ]
  • [ 78607-36-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 19
  • [ 153034-86-7 ]
  • [ 81290-20-2 ]
  • [ 81565-18-6 ]
Reference: [1] European Journal of Organic Chemistry, 2002, # 2, p. 327 - 330
  • 20
  • [ 153034-86-7 ]
  • [ 75-45-6 ]
  • [ 81565-18-6 ]
Reference: [1] Organic Letters, 2015, vol. 17, # 3, p. 532 - 535
  • 21
  • [ 153034-86-7 ]
  • [ 81565-18-6 ]
Reference: [1] RSC Advances, 2016, vol. 6, # 79, p. 75465 - 75469
  • 22
  • [ 153034-86-7 ]
  • [ 58310-28-4 ]
  • [ 81565-18-6 ]
Reference: [1] Chinese Journal of Chemistry, 2016, vol. 34, # 5, p. 481 - 484
  • 23
  • [ 153034-86-7 ]
  • [ 1692-15-5 ]
  • [ 53344-73-3 ]
Reference: [1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2852 - 2855
  • 24
  • [ 153034-86-7 ]
  • [ 109-94-4 ]
  • [ 153034-90-3 ]
YieldReaction ConditionsOperation in experiment
54%
Stage #1: With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3 h;
Stage #2: at -78℃; for 1.5 h;
A mixture of 2-chloro-3-iodopyridine(5.0g, 21mmol) in dry THF (30 mL) was slowly added to a cold (-78°C) solution oflithiumdiisopropylamide(15 mL, 30mmol) in dry THF (50 mL). The resulting mixture was stirred for 3h at this temperature.Ethylformate(4.0g, 54mmol) wasthenadded.Stirring continued for 1.5 h at the same temperature.Water (10 mL) was added to quench the reaction, and then theresultingmixture was warmed toroom temperature.2 MHCl(50 mL) was added and then the THF was removed under reduced pressure.The aqueous residue was extracted withethyl acetate(2 x 50 mL).The combined organic extracts were washed with brine, dried over Na2SO4andconcentrated under reduced pressure.The residuewas purified on silica gel(diethyl ether/petroleum ether1:4)to give the desired product as a yellow solid(3.0 g, 54percent yield).HNMR(500 MHz, CDCl3):δ10.22(s, 1H), 8.09(d, J =5.0Hz, 1H), 7.95(d,J =5.0Hz, 1H).
52%
Stage #1: With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3 h; Inert atmosphere; Schlenk technique
Stage #2: at -78℃; for 1.5 h; Inert atmosphere; Schlenk technique
According to the literature,17 a dry, argon-flushed Schlenk flask equipped with a magnetic stirring bar and a septum was charged with a solution of LDA (18.0 mmol, 1.0 M in THF) and cooled to –78 °C. 2-Chloro-3-iodopyridine (3.1 g, 13.0 mmol) was added dropwise tothe cooled solution. The resulting mixture was stirred for 3 h at –78 °C. Ethyl formate (2.5 g, 34.0 mmol) was then added and stirred for 1.5 hat –78 °C. The resulting solution was quenched with sat. aq NH4Cl (80 mL), extracted with EtOAc (3 × 120 mL), and the combined organic phases were dried (anhyd MgSO4). After filtration, the solvents were evaporated in vacuo. The crude product was purified by flash column chromatography on silica gel (i-hexane/EtOAc, 9:1 to 8:2 +Et3N 2percent) yielding 2-chloro-4-iodonicotinaldehyde as a yellow solid(1.8 g, 52percent). 1H NMR (400 MHz, CDCl3): δ = 10.19 (s, 1 H), 8.07 (d, J = 5.1 Hz, 1 H),7.94 (d, J = 5.1 Hz, 1 H).
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 18, p. 4370 - 4376
[2] Synthesis (Germany), 2018, vol. 50, # 1, p. 155 - 169
[3] Organic Letters, 2018, vol. 20, # 2, p. 345 - 348
  • 25
  • [ 153034-86-7 ]
  • [ 124-38-9 ]
  • [ 74-88-4 ]
  • [ 185041-05-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 24, p. 5947 - 5950
  • 26
  • [ 153034-86-7 ]
  • [ 185041-05-8 ]
Reference: [1] Patent: WO2014/160185, 2014, A2,
  • 27
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 28
  • [ 109-09-1 ]
  • [ 153034-86-7 ]
  • [ 116195-81-4 ]
  • [ 78607-36-0 ]
  • [ 258506-66-0 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 47, p. 13284 - 13297
  • 29
  • [ 153034-86-7 ]
  • [ 343781-36-2 ]
Reference: [1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
  • 30
  • [ 153034-86-7 ]
  • [ 343781-49-7 ]
Reference: [1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
  • 31
  • [ 153034-86-7 ]
  • [ 262423-77-8 ]
Reference: [1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
  • 32
  • [ 153034-86-7 ]
  • [ 858839-90-4 ]
YieldReaction ConditionsOperation in experiment
83% at 150℃; for 72 h; Sealed tube General procedure: To 4b/c/d (prepared above) and sodium acetate (2.0 eq.) in acetic acid (1.0M)was heated at 150°C in a sealed tube for 72h. The mixture was cooled to r.t. andconcentrated under reduced pressure. The residue was partitioned between ethylacetate (3 mL/mmol) and cold water (3mL/mmol). The aqueous layer was extractedwith ethyl acetate (3mL/mmol; 4x). The combined organic layers were successivelywashed with sat. NaHCO3 (1 mL/mmol), brine, dried (Na2SO4), filtered andconcentrated under reduced pressure. The crude material was purified by flashchromatography on silica gel to give products 1b/c/d, and details of individualcompounds are provided below.
38%
Stage #1: at 105℃; for 21 h;
Stage #2: With sodium carbonate In water
A mixture of 2-chloro-4-iodopyridine (4.943 g, 20.6 mmol) and formic acid(88percent, 10 mL) was stirred at 105° C. for 21 h. The excess of formic acid was removed in vacuo, and the mixture was quenched with 2 M aq Na2CO3, extracted with 0H2Cl2, dried over Na2SO4. After the solvent was removed under reduced pressure, the residue was purified by chromatography on silica gel eluted with CH2Cl2/MeOH to afford 1.716 g (38percent) of 4-iodopyridin-2(1H)-one as a solid. LC-MS Method 1 tR=0.82 min, m/z=222 (MH+); 1H NMR (400 MHz, (0D3)2SO) δ 7.14 (d, J=6.5 Hz, 1H), 6.87 (s, 1H), 6.49 (d, J=7.0 Hz, 1H).
22% With sodium acetate In acetic acid at 100℃; for 12 h; Step i: 4-iodopyridin-2(lH)-one
To 25 mL round bottom flask, were added 2-chloro-4-iodopyridine (1 g, 0.0042 mol) and acetic acid (10 mL). To the same flask, sodium acetate (1.7 g, 0.0209 mol) was added. The reaction mixture was maintained at 100 °C for 12 h. The reaction mixture was cooled to RT and poured into ice cold water. The aqueous layer partitioned with ethyl acetate. The organic layer was separated. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure to obtain the title compound [0.34 g, 22 percent]. H NMR (DMSO-de, 300 MHz): δ 11.80 (s, 1H), 7.15 (d, 1H), 6.87 (d, 1H), 6.50 (dd, 1H); LC-MS: 221.9 [M+H]+.
Reference: [1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Patent: US2010/331320, 2010, A1, . Location in patent: Page/Page column 89; 90
[3] Patent: WO2015/101928, 2015, A1, . Location in patent: Page/Page column 48
[4] Patent: WO2012/32014, 2012, A1, . Location in patent: Page/Page column 94
[5] Patent: US2012/214782, 2012, A1, . Location in patent: Page/Page column 40
[6] Patent: US2012/214785, 2012, A1, . Location in patent: Page/Page column 41
Historical Records

Related Functional Groups of
[ 153034-86-7 ]

Chlorides

Chemical Structure| 796851-03-1

[ 796851-03-1 ]

2,5-Dichloro-4-iodopyridine

Similarity: 0.87

Chemical Structure| 1227592-89-3

[ 1227592-89-3 ]

2-Chloro-4-iodo-6-methylpyridine

Similarity: 0.85

Chemical Structure| 153034-88-9

[ 153034-88-9 ]

2-Chloro-4-iodo-3-methylpyridine

Similarity: 0.85

Chemical Structure| 1197957-18-8

[ 1197957-18-8 ]

2-Chloro-4-iodo-5-methylpyridine

Similarity: 0.83

Chemical Structure| 98027-84-0

[ 98027-84-0 ]

2,6-Dichloro-4-iodopyridine

Similarity: 0.80

Related Parent Nucleus of
[ 153034-86-7 ]

Pyridines

Chemical Structure| 796851-03-1

[ 796851-03-1 ]

2,5-Dichloro-4-iodopyridine

Similarity: 0.87

Chemical Structure| 1227592-89-3

[ 1227592-89-3 ]

2-Chloro-4-iodo-6-methylpyridine

Similarity: 0.85

Chemical Structure| 153034-88-9

[ 153034-88-9 ]

2-Chloro-4-iodo-3-methylpyridine

Similarity: 0.85

Chemical Structure| 1197957-18-8

[ 1197957-18-8 ]

2-Chloro-4-iodo-5-methylpyridine

Similarity: 0.83

Chemical Structure| 98027-84-0

[ 98027-84-0 ]

2,6-Dichloro-4-iodopyridine

Similarity: 0.80