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[ CAS No. 1531-18-6 ]

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Inaccessible (Haz class 6.1), International USD 64.00
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Chemical Structure| 1531-18-6
Chemical Structure| 1531-18-6
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Product Details of [ 1531-18-6 ]

CAS No. :1531-18-6 MDL No. :MFCD12546403
Formula : C8H8N2 Boiling Point : 211.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :132.16 g/mol Pubchem ID :73739
Synonyms :

Safety of [ 1531-18-6 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P280-P301+P310-P311 UN#:3276
Hazard Statements:H301+H311+H331 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1531-18-6 ]

  • Upstream synthesis route of [ 1531-18-6 ]
  • Downstream synthetic route of [ 1531-18-6 ]

[ 1531-18-6 ] Synthesis Path-Upstream   1~16

  • 1
  • [ 3376-95-2 ]
  • [ 1531-18-6 ]
Reference: [1] Journal of Organic Chemistry, 1999, vol. 64, # 5, p. 1713 - 1714
[2] Synthesis, 2001, # 3, p. 373 - 375
[3] Synthesis, 1999, # 10, p. 1724 - 1726
[4] Advanced Synthesis and Catalysis, 2004, vol. 346, # 11, p. 1271 - 1274
[5] Bulletin de la Societe Chimique de France, 1958, p. 687,691
[6] Patent: US2901488, 1957, ,
  • 2
  • [ 536-33-4 ]
  • [ 1531-18-6 ]
Reference: [1] Tetrahedron Letters, 1999, vol. 40, # 4, p. 747 - 748
[2] Synthesis, 1999, # 10, p. 1724 - 1726
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3047 - 3052
[4] Synthesis, 2001, # 3, p. 373 - 375
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 8, p. 722 - 723
[6] Synthetic Communications, 1999, vol. 29, # 23, p. 4235 - 4239
[7] Journal of Organic Chemistry, 1988, vol. 53, # 10, p. 2166 - 2170
[8] Chemical Communications, 2012, vol. 48, # 91, p. 11247 - 11249
  • 3
  • [ 33252-30-1 ]
  • [ 97-93-8 ]
  • [ 1531-18-6 ]
Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 100 - 118
  • 4
  • [ 100-48-1 ]
  • [ 802294-64-0 ]
  • [ 1531-18-6 ]
Reference: [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582
  • 5
  • [ 10349-60-7 ]
  • [ 1531-18-6 ]
Reference: [1] Synthetic Communications, 2004, vol. 34, # 11, p. 2025 - 2029
  • 6
  • [ 536-33-4 ]
  • [ 1531-18-6 ]
  • [ 3376-96-3 ]
  • [ 3376-95-2 ]
  • [ 1531-16-4 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 37, p. 8848 - 8858
  • 7
  • [ 536-33-4 ]
  • [ 865-05-4 ]
  • [ 1531-18-6 ]
  • [ 3376-96-3 ]
  • [ 3376-95-2 ]
  • [ 1531-16-4 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 37, p. 8848 - 8858
  • 8
  • [ 100-48-1 ]
  • [ 64-17-5 ]
  • [ 1531-18-6 ]
Reference: [1] Chemistry Letters, 1984, p. 769 - 772
[2] Chemistry Letters, 1984, p. 769 - 772
[3] Chemistry Letters, 1984, p. 769 - 772
  • 9
  • [ 1531-16-4 ]
  • [ 1531-18-6 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1958, p. 687,691
  • 10
  • [ 15862-61-0 ]
  • [ 1531-18-6 ]
Reference: [1] Patent: US2901488, 1957, ,
  • 11
  • [ 4104-77-2 ]
  • [ 1531-18-6 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1958, p. 687,691
  • 12
  • [ 4009-26-1 ]
  • [ 1531-18-6 ]
Reference: [1] Patent: US2901488, 1957, ,
  • 13
  • [ 50826-64-7 ]
  • [ 1531-18-6 ]
Reference: [1] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 915,918; engl. Ausg. S. 898
  • 14
  • [ 4833-24-3 ]
  • [ 1531-18-6 ]
Reference: [1] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 915,918; engl. Ausg. S. 898
  • 15
  • [ 38594-62-6 ]
  • [ 1531-18-6 ]
Reference: [1] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 915,918; engl. Ausg. S. 898
  • 16
  • [ 1531-18-6 ]
  • [ 536-33-4 ]
YieldReaction ConditionsOperation in experiment
67% With sodiumsulfide nonahydrate In N,N-dimethyl-formamide at 130℃; for 2.5 h; General procedure: Benzonitrile 1a (1 mmol), Na2S*9H2O (1.2 mmol) and DMF (1 mL) were added into a 10 mL bottle. The reactor was placed in a heating magnetic stirrer at 130 °C. After 2.5 h, by adding about 3 mL H2O after the reaction to disperse the solid product, the reaction mixture was extracted with EtOAc (3 x 3 mL), and the mixture was purified by column chromatography.
Reference: [1] RSC Advances, 2018, vol. 8, # 1, p. 170 - 175
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582
[3] Heterocycles, 2018, vol. 96, # 3, p. 509 - 517
[4] Bulletin de la Societe Chimique de France, 1958, p. 687,691
[5] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 915,918; engl. Ausg. S. 898
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