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Chemical Structure| 1532517-45-5 Chemical Structure| 1532517-45-5

Structure of 1532517-45-5

Chemical Structure| 1532517-45-5

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Product Details of [ 1532517-45-5 ]

CAS No. :1532517-45-5
Formula : C16H12BrClFNO
M.W : 368.63
SMILES Code : O=C(N1CCCC2=C1C=CC(Br)=C2)C3=C(F)C=CC=C3Cl

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Application In Synthesis of [ 1532517-45-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1532517-45-5 ]

[ 1532517-45-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 874219-34-8 ]
  • [ 1532517-45-5 ]
  • [ 1532508-18-1 ]
YieldReaction ConditionsOperation in experiment
27.7% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 100.0℃; General procedure: Example 3: Synthesis of 5-(l-(2-chloro-6-fluorobenzoyl)-l,2,3,4- tetrahydroquinolin-6-yl)-2-fluorobenzamide [00286] To a stirred mixture of intermetidate 1-C (0.1 g, 0.28 mmol), Pd(dppf)Cl2 (0.024 g, 0.03 mmol), and K2C03 (0.082 mg, 0.59 mmol) in 5 mL of DMF was added 3-carbamoyl-4- fluorophenyl boronic acid (0.054 mg, 0.28 mmol). The mixture was heated overnight at 100C. Solvent was removed in vacuo, and the residue was purified by preparative TLC and preparative HPLC to provide the titled compound as a colorless solid (33 mg, 27.7%). 1H NMR (300 MHz, CD3OD): δ 8.06 - 6.92 (m, 9H), 3.97 - 3.48 (m, 2H), 2.89 - 2.80 (m, 2H), 2.08 - 1.93 (m, 2H). HPLC = 98.9% (214 nm), 98.6% (254 nm), tR = 6.49 min. LC-MS: mJz = 427.1 [M+H]+.
 

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