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Chemical Structure| 153281-13-1 Chemical Structure| 153281-13-1

Structure of 153281-13-1

Chemical Structure| 153281-13-1

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Product Details of [ 153281-13-1 ]

CAS No. :153281-13-1
Formula : C5H4BrClN2
M.W : 207.45
SMILES Code : ClC1=NC=C(CBr)C=N1
MDL No. :MFCD22376133

Safety of [ 153281-13-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 153281-13-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153281-13-1 ]

[ 153281-13-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1046816-75-4 ]
  • [ 153281-13-1 ]
YieldReaction ConditionsOperation in experiment
With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20℃; for 0.666667h; CBr4 (2.68 g, 8.07 mmol) in 5 mL of DCM was added to a stirred, cooled (to 0°C) mixture of <strong>[1046816-75-4](2-chloropyrimidin-5-yl)methanol</strong> (1.19 g, 8.23 mmol) and triphenylphosphine(2.116 g, 8.07 mmol) in 35 mL of DCM and the mixture was stirred at 0°C for 10 mm. Then,the reaction mixture was removed from the ice bath and stirred at RT for 30 mm. TLC showedthe reaction was near completion. The reaction mixture was concentrated to 1/2 volume, filtered and concentrated down. The residue was purified by silica gel column chromatography, eluting with EtOAc/isohexane (030percent) to give the desired product. LC-MS [M+H]: 208.93
  • 2
  • [ 153281-13-1 ]
  • [ 25602-68-0 ]
  • 8-((2-chloropyrimidin-5-yl)methyl)-8-diazaspiro[3.2.1]octan-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With potassium carbonate; In acetonitrile; for 1h;Reflux; (1) Preparation of 8-((2-chloropyiimidin-5-yl)methyl)-8-diazaspiro[3.2.1] octan-3-one To 20 mL acetonitrile were added 5-bromomethyl-2-chloropyrimidine (621 mg, 3.0 mmol), <strong>[25602-68-0]3-oxo-8-azabicyclo[3.2.1]octane hydrochloride</strong> (324 mg, 2.0 mmol) and potassium carbonate (552 mg, 4.0 mmol). The mixture was heated to reflux for 1 h.The solvent was distilled under rotation, and the residue was separated by silica gel column chromatography (petroleum ether: acetic ether=5: 1) to get the product (387 mg, yield: 77percent).
 

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