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Chemical Structure| 153437-50-4 Chemical Structure| 153437-50-4

Structure of 153437-50-4

Chemical Structure| 153437-50-4

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Product Details of [ 153437-50-4 ]

CAS No. :153437-50-4
Formula : C12H12ClN3O
M.W : 249.70
SMILES Code : ClC1=C2C=C(N3CCOCC3)C=CC2=NC=N1
MDL No. :MFCD27717275

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Application In Synthesis of [ 153437-50-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153437-50-4 ]

[ 153437-50-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 153437-50-4 ]
  • [ 52537-00-5 ]
  • 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6-morpholin-4-yl-quinazoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; sodium hydrogencarbonate; In ethyl acetate; 1,2-dichloro-ethane; Example 120 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6-morpholin-4-yl-quinazoline 4-Chloro-6-morpholino-quinazoline (382 mg, 1.53 mmol) and <strong>[52537-00-5]6-chloroindoline</strong> (258 mg, 1.63 mmol) were heated at reflux in 8 mL of 1,2-dichloroethane and pyridine (264 mg, 3.36 mmol) for 16 hours. The reaction mixture was vacuum evaporated and partitioned between 100 mL of ethyl acetate and 50 mL of 5% sodium bicarbonate. The organic layer was washed with an additional 50 mL of bicarbonate and 50 mL of brine, dried with magnesium sulfate, filtered and evaporated in vacuo to a residue. This was purified by flash chromatography on silica gel eluted with 20% acetone/methylene chloride. The pure solid isolated from the column was converted to its hydrochloride salt by dissolution in methanol containing 1.1 equivalents of anhydrous hydrogen chloride and precipitation with ether; 396 mg (65%); M.P. 277-279 C.
 

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