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[ CAS No. 15360-02-8 ]

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Chemical Structure| 15360-02-8
Chemical Structure| 15360-02-8
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Product Details of [ 15360-02-8 ]

CAS No. :15360-02-8 MDL No. :MFCD03412397
Formula : C11H14O3 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :194.23 g/mol Pubchem ID :586598
Synonyms :

Safety of [ 15360-02-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 15360-02-8 ]

  • Downstream synthetic route of [ 15360-02-8 ]

[ 15360-02-8 ] Synthesis Path-Downstream   1~13

  • 3
  • [ 862506-74-9 ]
  • [ 15360-02-8 ]
  • 2-(3-<i>tert</i>-butoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (4-pentyl-phenyl)-amide [ No CAS ]
  • 5
  • [ 790689-71-3 ]
  • [ 15360-02-8 ]
  • C23H24N2O5S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 1. 3-^r^-butoxy-N-[2-(hydroxymethyl)-l,3-benzothiazol-5-yl]benzamide.The amine, allyl {5-[(tert-butoxycarbonyl)amino]-l,3-benzothiazol-2-yl}methyl carbonate (200 mg, 0.757 mmol), 3-fert-butoxybenzoic acid (147 mg, 0.757 mmol), EDC (290 mg, 1.51 mmol), and DMAP (185 mg, 1.51 mmol) were mixed in DCM (10.0 mL) and DMF (10.0 mL). The mixture was stirred for 18 hours, and the solvents were evaporated. The residue was dissolved in DCM and washed with a saturated solution OfNaHCO3. The mixture was dried with Na2SO4, filtered and concentrated under reduced pressure. The crude amide product was mixed with aqueous IM NaOH (10.0 mL) and THF (10.00 mL) for removal of the alloc protecting group. The aqueous phase was extracted with DCM. The organic phases were collected, dried with Na2SO4, filtered and concentrated under reduced pressure. The product was purified by flash chromatography eluting with mixtures of hexanes and ethyl acetate (2:1, 1:1) to yield the title compound (179 mg, 0.502 mmol, 66%). 1H NMR (400 MHz, METHANOL-D4) delta ppm 1.39 (s, 9 H) 4.95 (s, 2 H) 7.23 (dd, J=8.01, 1.56 Hz, 1 H) 7.43 (t, j=7.91 Hz, 1 H) 7.58 (s, 1 H) 7.69 (d, J=7.81 Hz, 1 H) 7.72 (dd, j=8.79, 1.95 Hz, 1 H) 7.95 (d, j=8.79 Hz, 1 H) 8.40 (d, J=I.56 Hz, 1 H). MS [MH+] calc. 357.1, found 357.0. Anal found C 64.50%, H 5.76%, N 7.79%.
  • 6
  • [ 79-37-8 ]
  • [ 1005777-50-3 ]
  • [ 15360-02-8 ]
  • [ 1005786-54-8 ]
YieldReaction ConditionsOperation in experiment
57% With 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; N,N-dimethyl-formamide; Example 367 Production of 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide Using <strong>[15360-02-8]3-tert-butoxybenzoic acid</strong> (110 mg, 0.58 mmol), oxalyl chloride (63 muL, 0.73 mmol), N,N-dimethylformamide (1 drop), tetrahydrofuran (4.0 mL), N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (150 mg, 0.49 mmol) and N-methylpyrrolidone (4.0 mL) as starting materials and in the same manner as in Example 335, the title compound (160 mg, 57%) was obtained as a white powder. 1H-NMR (DMSO-d6, 300 MHz) delta 0.74-0.87 (4H, m), 1.33 (9H, s), 1.85-1.98 (1H, m), 6.90-7.03 (1H, m), 7.07 (1H, d, J=9.6 Hz), 7.16-7.27 (1H, m), 7.36-7.48 (2H, m), 7.48-7.53 (1H, m), 7.61-7.70 (2H, m), 7.73 (1H, t, J=2.1 Hz), 7.98 (1H, s), 8.05 (1H, d, J=9.6 Hz), 10.34 (1H, s), 11.09 (1H, s).
  • 7
  • [ 15360-02-8 ]
  • [ 317806-90-9 ]
  • 3-tert-butoxy-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[15360-02-8]3-tert-butoxy-benzoic acid</strong> (0.15 g, 0.774 mmol) in dimethylformamide(5 ml) is added HBTU (0.44 g, 1.5 eq) followed by the addition of diisopropylethylamine (0.296ml, 3.0 eq). The mixture is stirred at room temperature for five minutes. A solution of 4-(2-morpholin-4-yl-ethoxy)-naphthalen-l-ylamine (0.21 g) in dimethylformamide (2 ml) is thenadded. This mixture is stirred at room temperature for 15 h, diluted with water and extractedwith ethyl acetate. The organic layer is washed with water, dried over Na2SO4 and evaporated.The residue is purified by column chromatography on silica gel (ethyl acetate) to give 3-tert-butoxy-N-[4-(2-morpholin-4-yl-ethoxy)-naphmalen-l-yl]-benzamide (0.146 g). Mp: 50-51 C.'HNMR (300 MHz, DMSO-d6) 5 10.25 (s, 1H), 8.22 (m, 1H), 7.85 (m, 2H), 7.66 (s, 1H), 7.55(m, 2H), 7.23 (d, J= 7.5 Hz, 1H), 7.03 (d, J= 8.1 Hz, 1H), 4.31 (i,J= 5.1 Hz, 2H), 3.61 (t, J =4.2 Hz, 4H), 2.89 (brs, 2H), 2.58 (brs, 4H), 1.35 (s, 9H). MS: 449 (M+l).
  • 8
  • ethyl 3-(t-butoxy)benzoate [ No CAS ]
  • [ 15360-02-8 ]
  • 9
  • [ 15360-02-8 ]
  • [ 917-54-4 ]
  • [ 99376-84-8 ]
  • 10
  • [ 15360-02-8 ]
  • [ 1005786-54-8 ]
  • 11
  • [ 15360-02-8 ]
  • [ 1233518-24-5 ]
  • 12
  • [ 790689-68-8 ]
  • [ 15360-02-8 ]
  • C23H24N2O5S [ No CAS ]
  • 13
  • [ 790689-68-8 ]
  • [ 15360-02-8 ]
  • 3-tert-butoxy-N-[2-(hydroxymethyl)-1,3-benzothiazol-5-yl]benzamide [ No CAS ]
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