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[ CAS No. 1538-08-5 ]

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Chemical Structure| 1538-08-5
Chemical Structure| 1538-08-5
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CAS No. :1538-08-5 MDL No. :MFCD00221440
Formula : C2H3F3N2O Boiling Point : 192.3°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :128.05 g/mol Pubchem ID :229753
Synonyms :

Safety of [ 1538-08-5 ]

Signal Word:Danger Class:4.1
Precautionary Statements:P210-P240-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P370+P378-P403+P233-P501 UN#:1325
Hazard Statements:H228-H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1538-08-5 ]

  • Upstream synthesis route of [ 1538-08-5 ]
  • Downstream synthetic route of [ 1538-08-5 ]

[ 1538-08-5 ] Synthesis Path-Upstream   1~8

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Reference: [1] Patent: EP1710234, 2006, A1, . Location in patent: Page/Page column 62
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YieldReaction ConditionsOperation in experiment
96% With hydrazine hydrate In ethanol Step 2
Preparation of trifluoroacetyl hydrazide
A mixture of ethyl trifluoroacetate (14.2 g, 0.10 mol) and hydrazine hydrate (5.54 g, 0.11 mol) in ethanol (25 mL) was heated at reflux for 6 hours.
Solvent was removed and the resulting residue was dried in vacuum to give trifluoroacetyl hydrazide (12.3 g, 96percent) as a clear oil which solidified upon standing.
96% With hydrazine In ethanol for 6 h; Heating / reflux Step 2:
Preparation of trifluoroacetyl hydrazide
A mixture of ethyl trifluoroacetate (14.2 g, 0.10 mol) and hydrazine hydrate (5.54 g, 0.11 mol) in ethanol (25 mL) was heated at reflux for 6 hours.
Solvent was removed and the resulting residue was dried in vacuum to give trifluoroacetyl hydrazide (12.3 g, 96percent) as a clear oil which solidified upon standing.
54% With hydrazine hydrate In ethanol for 3 h; Reflux Ethyl trifluoroacetate (1.03 g, 0.865 mL, 7.25 mmol) and hydrazine monohydrate (80percent w/w, 0.498 g, 0.475 mL, 7.97 mmol, 1.1 equiv.) were dissolved in ethanol (1.4 mL) and heated under reflux for 3 h. The solvent was removed under reduced pressure, and the residue was taken up in EtOAc (10 mL) and extracted with water (10 mL). The aqueous phase was extracted with EtOAc (4.x.10 mL), the combined organic phases were washed with water (5 mL), dried over magnesium sulphate and freed from the solvent under reduced pressure. The residue was purified by column chromatography (SiO2, EtOAc/n-hexane 1/2, v/v). 504 mg of trifluoroacetic acid hydrazide (3.94 mmol, 54percent yield) were obtained in the form of a colourless oil.
Reference: [1] Patent: US6423713, 2002, B1,
[2] Patent: US6514977, 2003, B1,
[3] Patent: US6979686, 2005, B1, . Location in patent: Page/Page column 134
[4] Magnetic Resonance in Chemistry, 1990, vol. 28, p. 331 - 336
[5] Journal of the Indian Chemical Society, 2010, vol. 87, # 5, p. 589 - 593
[6] Journal of Organic Chemistry, 2013, vol. 78, # 16, p. 8054 - 8064
[7] Patent: US2012/46301, 2012, A1, . Location in patent: Page/Page column 38
[8] Journal of Fluorine Chemistry, 1995, vol. 70, # 1, p. 31 - 38
[9] Journal of Organic Chemistry, 1960, vol. 25, p. 102 - 105
[10] Journal of Chemical Research, Miniprint, 1999, # 5, p. 1301 - 1308
[11] Patent: WO2006/9886, 2006, A1, . Location in patent: Page/Page column 41
[12] Patent: EP1710234, 2006, A1, . Location in patent: Page/Page column 62
[13] Patent: WO2010/122578, 2010, A2, . Location in patent: Page/Page column 54-55
[14] Patent: US2012/25177, 2012, A1,
[15] Angewandte Chemie - International Edition, 2012, vol. 51, # 23, p. 5642 - 5646
[16] Dyes and Pigments, 2013, vol. 99, # 1, p. 67 - 73
[17] Angewandte Chemie - International Edition, 2015, vol. 54, # 3, p. 786 - 791[18] Angew. Chem., 2015, vol. 54, # 3, p. 798 - 803,6
[19] Patent: EP2862856, 2015, A1, . Location in patent: Paragraph 0653; 0654
[20] Journal of Materials Chemistry C, 2016, vol. 4, # 43, p. 10246 - 10252
[21] Tetrahedron, 2016, vol. 72, # 50, p. 8335 - 8341
[22] Journal of Nanoscience and Nanotechnology, 2018, vol. 18, # 10, p. 7047 - 7052
[23] Patent: WO2006/119260, 2006, A2, . Location in patent: Page/Page column 41
  • 3
  • [ 407-25-0 ]
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Reference: [1] Patent: WO2007/150026, 2007, A2, . Location in patent: Page/Page column 71
  • 4
  • [ 431-47-0 ]
  • [ 302-01-2 ]
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Reference: [1] Journal of Organic Chemistry, 1961, vol. 26, p. 4407 - 4409
[2] , Gmelin Handbook: F: PerFHalOrg.8, 3, page 55 - 151,
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Reference: [1] Journal of Organic Chemistry, 1961, vol. 26, p. 4407 - 4409
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, # 12, p. 1911 - 1914[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 12, p. 2735 - 2739
[4] Chemistry of Heterocyclic Compounds, 2016, vol. 52, # 2, p. 133 - 139[5] Khim. Geterotsikl. Soedin., 2016, vol. 52, # 2, p. 133 - 139,7
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Reference: [1] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3685 - 3688
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Reference: [1] C.A., 1972, vol. 77, p. 140747
[2] , Gmelin Handbook: F: PerFHalOrg.8, 3, page 55 - 151,
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Reference: [1] Chemistry of Heterocyclic Compounds, 2016, vol. 52, # 2, p. 133 - 139[2] Khim. Geterotsikl. Soedin., 2016, vol. 52, # 2, p. 133 - 139,7
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